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The development of collagen based Composite scaffolds for bone regeneration

Bioactive Materials 2018年第1期3卷 129-138页

作者： Dawei Zhang Xiaowei Wu Jingdi Chen Kaili Lin School&Hospital of Stomatology Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai 200072China Institute of Biomedical and Pharmaceutical Technology Fuzhou UniversityFuzhou 350002China

Bone is consisted of bone matrix,cells and bioactive factors,and bone matrix is the combination of inorganic minerals and organic polymers.Type I collagen fibril made of five triple-helical collagen chains is the main organic polymer in bone matrix.It plays an important role in the bone formation and remodeling process.Moreover,collagen is one of the most commonly used scaffold materials for bone tissue engineering due to its excellent biocompatibility and biodegradability.However,the low mechanical strength and osteoinductivity of collagen limit its wider applications in bone regeneration field.By incorporating different biomaterials,the properties such as porosity,structural stability,osteoinductivity,osteogenicity of collagen matrixes can be largely improved.This review summarizes and categorizes different kinds of biomaterials including bioceramic,carbon and polymer materials used as components to fabricate collagen based Composite scaffolds for bone regeneration.Moreover,the possible directions of future research and development in this field are also proposed.

关键词： Collagen Bone regeneration Composite scaffolds Biomaterials Tissue engineering

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A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process

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Regenerative Biomaterials 2017年第4期4卷 233-242页

作者： Yao Deng Mengjiao Zhang Xianchun Chen Ximing Pu Xiaoming Liao Zhongbing Huang Guangfu Yin College of Materials Science and Engineering Sichuan UniversityChengdu 610064PR China

Desirable scaffolds for tissue engineering should be biodegradable carriers to supply suitablemicroenvironments mimicked the extracellular matrices for desired cellular interactions and to providesupports for the formation of new tissues. In this work, a kind of slightly soluble bioactiveceramic akermanite (AKT) powders were aboratively selected and introduced in the PLGA matrix,a novel L-lactide modified AKT/poly (lactic-co-glycolic acid) (m-AKT/PLGA) composite scaffold wasfabricated via a solvent casting-particulate leaching method improved by solvent self-proliferatingprocess. The effects of m-AKT contents on properties of Composite scaffolds and on MC3T3-E1 cellularbehaviors in vitro have been primarily investigated. The fabricated scaffolds exhibited threedimensionalporous networks, in which homogenously distributed cavities in size of 300–400 lmwere interconnected by some smaller holes in a size of 100–200 lm. Meanwhile, the mechanicalstructure of scaffolds was reinforced by the introduction of m-AKT. Moreover, alkaline ionic productsreleased by m-AKT could neutralize the acidic degradation products of PLGA, and the apatitemineralizationability of scaffolds could be largely improved. More valuably, significant promotionson adhesion, proliferation, and differentiation of MC3T3-E1 have been observed, which implied thecalcium, magnesium and especially silidous ions released sustainably from Composite scaffoldscould regulate the behaviors of osteogenesis-related cells.

关键词： akermanite PLGA Composite scaffolds solvent self-proliferating process

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Magnesium incorporated chitosan based scaffolds for tissue engineering applications

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Bioactive Materials 2016年第2期1卷 132-139页

作者： Udhab Adhikari Nava PRijal Shalil Khanal Devdas Pai Jagannathan Sankar Narayan Bhattarai Department of Mechanical Engineering North Carolina A&T State UniversityGreensboroNCUSA Department of Chemical Biological and BioengineeringNorth Carolina A&T State UniversityGreensboroNCUSA Department of Energy and Environmental Systems North Carolina A&T State UniversityGreensboroNCUSA NSF ERC for Revolutionizing Metallic Biomaterials North Carolina A&T State UniversityGreensboroNCUSA

Chitosan based porous scaffolds are of great interest in biomedical applications especially in tissue engineering because of their excellent biocompatibility in vivo,controllable degradation rate and tailorable mechanical properties.This paper presents a study of the fabrication and characterization of bioactive scaffolds made of chitosan(CS),carboxymethyl chitosan(CMC)and magnesium gluconate(MgG).scaffolds were fabricated by subsequent freezing-induced phase separation and lyophilization of polyelectrolyte complexes of CS,CMC and MgG.The scaffolds possess uniform porosity with highly interconnected pores of 50-250 μm size range.Compressive strengths up to 400 kPa,and elastic moduli up to 5 MPa were obtained.The scaffolds were found to remain intact,retaining their original threedimensional frameworks while testing in in-vitro conditions.These scaffolds exhibited no cytotoxicity to 3T3 fibroblast and osteoblast cells.These observations demonstrate the efficacy of this new approach to preparing scaffold materials suitable for tissue engineering applications.

关键词： Chitosan Magnesium gluconate Carboxymethyl chitosan Tissue engineering Composite scaffolds

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