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Inflammatory responses of the rat lungs in cold-dryness syndrome in the northwest of China

Journal of Traditional Chinese Medicine 2012年第2期32卷 234-237页

作者：高振哈木拉提·吾甫尔荆晶廖春燕徐丹李风森 Traditional Chinese Medicine Hospital affiliated with Xinjiang Medical University & National Clinical Research Base of Traditional Chinese Medicine Xin Jiang Medical University

OBJECTIVE:To examine changes in body weight and the lung inflammation factors interleukin-1β(IL-1β),interleukin-8(IL-8),IL-10 and tumor necrosis factor-α(TNF-α) in a rat model of cold-dryness syndrome in Northwest(Xinjiang) China to provide a reference for treating chronic obstructive pulmonary disease(COPD) with local ***:The rat COPD model was established by intratracheal instillation of porcine pancreatic elastase(PPE) in combination with cigarette smoking(CS).The rat model of cold-dryness syndrome of COPD in the northwest of China was set up by intratracheal instillation of PPE in combination with CS and environmental cold-dryness *** level of IL-1β,IL-8,IL-10 and TNF-α in Bronchoalveolar lavage fluid(BALF) were measured by enzyme-linked immunosorbent assay(ELISA).The data were analyzed using the software SPSS ***:1) Body weight was less in the two model groups than that of control group(Pcold-dryness group was less than that of PPE plus CS group(Pcold-dryness group than that of control group(Pcold-dryness group and PPE plus CS group than that of control group(Pdryness may aggravate such a condition Lung inflammation in the model was mainly manifested by an increase in IL-1β,IL-8 and TNF-α levels,with no change in IL-10 ***-dryness may aggravate lung inflammation of COPD.

关键词： Pulmonary disease Chronic obstructive pulmonary disease cold-dryness syndrome Northwest China Inflammatory reaction

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Expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease with a cold-dryness symptom pattern

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Journal of Traditional Chinese Medicine 2016年第5期36卷 671-677页

作者： Gao Zhen Halmurat Upur Wang Jing Jing Jing Li Zheng Xu Dan Li Fengsen Post-doctoral Scientific Research Station of Tradi-tional Chinese Medicine Hospital affiliated to Xinjiang Medical University Urumqi 830000China National Clinical Research Base of Traditional Chinese Medicine Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830000China

OBJECTIVE: To reveal the effects on expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease(COPD) and a cold-dryness symptom pattern induced by elastase and ***: The COPD model was established with an elastase dose into the trachea combined with exposure to smoking; the COPD model cold-dryness symptom pattern was further developed by exposure to a cold, dry environment. After 90 days,pathologic lung sections, inflammatory cytokine levels(measured by enzyme linked immunosorbent assay), m RNA and protein expression of mucus-associated proteins and aquaporins(measured by real-time polymerase chain reaction and western blots) were ***: Cytokines interleukin-6(IL-6), interleukin-8(IL-8), and tumor necrosis factor-α(TNF-α) in the COPD and the cold-dryness symptom pattern COPD groups were all significantly higher than in controls(each P cold-dryness symptom pattern COPD group than in the COPD group(each P cold-dryness symptom pattern COPD and COPD groups was lower than in the control group(P cold-dryness symptom pattern COPD group was lower than the COPD group(P cold-dryness symptom pattern COPD group and COPD group was higher than in the control group(each P cold-dryness symptom pattern COPD group was higher than the COPD group(P cold-dryness symptom pattern COPD group cold-dryness symptom pattern COPD group was lower than that in the COPD group which was lower again than in the control group. MUC5 AC and MUC5 B expression in the cold-dryness symptom pattern COPD group was higher than in the COPD group and higher again than in the control ***

关键词： Pulmonary disease chronic obstructive cold-dryness syndrome Aquaporins Mucins

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