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Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1697-1708页

作者： Yu JIN Jianze WANG Yiqi LIU Xinagyu SAI Yanchao JI School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbinChina College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbinChina

To explore the clustered voltage balancing mechanism of the cascaded H-bridge static synchronous compensator(STATCOM),this paper analyzes the causes of unbalanced clustered voltage.The negative-sequence current caused by the compensation of unbalanced reactive power or detection and control errors and the zero-sequence voltage caused by voltage drift of the STATCOM neutral point contribute to unbalanced clustered voltage.On this basis,this paper proposes a control strategy to inject negative-sequence current and zero-sequence voltage simultaneously.The injection of negative-sequence current may cause current asymmetry in the grid,and the zerosequence injection has a relatively limited balancing ability in the clustered voltages.The proposed control strategy can not only generate a faster balancing response than the traditional zero-sequence voltage injection method,but also lower the extent of current asymmetry compared with the traditional negative-sequence current injection method.Then,the negative-sequence current and zero-sequence voltage injection are further transformed into the dq frame to establish a unified frame.The effectiveness of the proposed control strategy is verified by the simulation and experimental results.

关键词： Cascaded static synchronous compensator(STATCOM) clustered voltage Control strategy Negative-sequence current Zero-sequence voltage

The Performance Analysis for Distributed Collaborative Beamforming Transmission of clustered Mobile Sensor Network

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Journal of Harbin Institute of Technology(New Series) 2016年第4期23卷 8-14页

作者： Fangyuan Yu Dezhi Li Qing Guo Bo Zeng Zhenyong Wang Communication Research Center Harbin Institute of Technology

Sensor nodes cannot directly communicate with the distant unmanned aerial vehicle( UAV) for their low transmission power. Distributed collaborative beamforming from sensor nodes within a cluster is proposed to provide high speed data transmission to the distant UAV. The bit error ratio( BER) closed-form expression of distributed collaborative beamforming transmission with mobile sensor nodes has been derived. Furthermore,based on the theoretical BER analysis and the numerical results,we have analyzed the impacts of nodes 'mobility,number of sensor nodes,transmission power and the elevation angle of UAV on the BER performance of collaborative beamforming. And we come to the following conclusions: the mobility of sensor nodes largely decreases the BER performance; when the position deviation radius is large,incensement in power cannot improve BER anymore; the size of cluster should be bigger than 10 for the purpose of achieving good BER performance in Rayleigh fading channel.

关键词： clustered sensor network collaborative beamforming mobile nodes unmanned aerial vehicle BERCLC number: TN911.7 Document code: A Article ID: 1005-9113(2016)03-0008-07

clustered Pain Procedures in Skin-to-Skin Contact (SSC) Position for Full Term Newborns

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World Journal of Neuroscience 2017年第1期7卷 38-47页

作者： Raouth R. Kostandy Susan M. Ludington-Hoe Cleveland State University School of Nursing Cleveland OH USA Bolton School of Nursing Case Western Reserve University Cleveland OH USA

As a part of their routine care, full term newborns face many painful procedures immediately after birth and during the first couple days of life. Skin-to-Skin Contact (SSC) has been recommended as a non-pharmacological pain management intervention in newborns. However, the use of SSC in labor and delivery rooms as well as in postnatal units and nurseries is limited due to the discomfort that the nurses and phlebotomists themselves experience during positioning the newborns and themselves to complete these routine procedures. The objective of this paper is to describe a step-by-step procedure that was developed and used in a randomized clinical trial to manage newborns pain during clustered pain procedures. The procedure worked well and no complaints of discomfort were reported by the nurses during the study.

关键词： Full Tern Newborns clustered Painful Procedures Skin-to-Skin Contact (SSC)

dCACH: Content Aware clustered and Hierarchical Distributed Deduplication

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Journal of Software Engineering and Applications 2019年第11期12卷 460-490页

作者： Girum Dagnaw Ke Zhou Hua Wang Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Wuhan China

In deduplication, index-lookup disk bottleneck is a major obstacle which limits the throughput of backup processes. One way to minimize the effect of this issue and boost speed is to use very high course-grained chunks for deduplication at a cost of low storage saving and limited scalability. Another way is to distribute the deduplication process among multiple nodes but this approach introduces storage node island effect and also incurs high communication cost. In this paper, we explore dCACH, a content-aware clustered and hierarchical deduplication system, which implements a hybrid of inline course grained and offline fine-grained distributed deduplication where routing decisions are made for a set of files instead of single files. It utilizes bloom filters for detecting similarity between a data stream and previous data streams and performs stateful routing which solves the storage node island problem. Moreover, it exploits the negligibly small amount of content shared among chunks from different file types to create groups of files and deduplicate each group in their own fingerprint index space. It implements hierarchical deduplication to reduce the size of fingerprint indexes at the global level, where only files and big sized segments are deduplicated. Locality is created and exploited first using the big sized segments deduplicated at the global level and second by routing a set of consecutive files together to one storage node. Furthermore, the use of bloom filter for similarity detection between streams has low communication and computation cost while it enables to achieve duplicate elimination performance comparable to single node deduplication. dCACH is evaluated using a prototype deployed on a server environment distributed over four separate machines. It is shown to have 10× the speed of Extreme_Binn with a minimal communication overhead, while its duplicate elimination effectiveness is on a par with a single node deduplication system.

关键词： clustered Deduplication Content Aware Grouping Hierarchical Deduplication Stateful Routing Similarity Bloom Filters

Theoretically Catalytic Synthesis of 5-Nitro-1,2,4-Triazol-3-One in Inert Gas clustered System (X<sub>6</sub>, X = He, Ne)

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Open Journal of Physical Chemistry 2012年第2期2卷 107-116页

作者： Min-Hsien Liu Ming-Yung Wu Department of Chemical and Materials Engineering Chung Cheng Institute of Technology National Defense University Taiwan

Inert gas-clustered systems (Xn, X = He, Ne, Ar and n = 2 - 20) were established in this study and their stability as a result of interparticulate interaction was examined. Ferric chloride and ferrous oxides were used as catalysts to promote reaction, and 5-nitro-1,2,4-triazol-3-one (NTO) was theoretically synthesized under an inert gas (X6)-clustered environment in this study. The raw material, urea, initially underwent chlorination using chlorine as the reagent, followed by amination, formylation and nitration. Reaction routes closely related to the experimental processes were successfully constructed, and the corresponding energy barriers were estimated for each elementary reaction. The findings revealed that the average errors in the B3LYP/6-31G(d, p)-calculated geometry and vibrational frequency of NTO in an Ne6 system relative to the observed values were 0.83% and 1.84%, respectively. The neon gas-clustered system achieved greater stabilization, which results from the difference in self-consistent field energy (ESCF), than the corresponding stabilization acquired in a helium- or argon-based system. Ferric chloride serves as a good catalyst to reduce the energy barrier of the chlorination reaction, and ferrous oxide is suitable for catalyzing the amination, formylation and nitration reactions, although nitric acid is the better agent for nitration. The catalytic Ne6-clustered reaction system is suggested to be a more feasible pathway for the synthesis of NTO.

关键词： NTO Inert Gas clustered System Metal Catalyst Formylation Reaction

A Hybrid Key Management Scheme Based on clustered Wireless Sensor Networks

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Wireless Sensor Network 2012年第8期4卷 197-201页

作者： Pengcheng Zhao Yong Xu Min Nan Department of Mathematics and Computer Science Anhui Normal University Wuhu China

According to the weakness of session key construction based on node’s own location, we propose a hybrid key management scheme which based on clustered wireless sensor networks. The use of hierarchical thinking, reducing the amount of key storage and computing, while supporting network topology, dynamic key management for which aims to prevent leakage. Through analyzing, it shows that the scheme have certain advantages in key connectivity, security, communication and energy consumption.

关键词： clustered Wireless Sensor Networks Key Management Network Security

In vitro transcribed sgRNA causes cell death by inducing interferon release

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Protein & Cell 2019年第6期10卷 461-465页

作者： Wei Mu Na Tang Chen Cheng Wen Sun Xiaofei Wei Haoyi Wang State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China School of Life Sciences University of Science and Technology of China Hefei 230026 China Beijing Cord Blood Bank Beijing 100176 China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China

Dear editor The clustered regularly in terspaced short palindromic repeats (CRISPR) and the CRISPR-associated proteins 9 (Cas9) systems are powerful tools for gene editing. Ribonucleoprotein (RNP) complex composed of Cas9 pro? tein and sgRNA binds to specific genomic loci and gen erate DNA double strand breaks. While plasmids expressing Cas9 protein and sgRNA are routinely transfected into various cell lines to perform gene editing (Cong et al., 2013;Mali et al., 2013;Ran et al., 2013), direct delivery of Cas9-sgRNA RNP has shown higher efficiency and lower off-target effects (Kim et al., 2014), especially in human primary cells such as T cells (Hendel et al., 2015;Schumann et al., 2015). SgRNA can be gen erated by either in vitro transcript! on (IVT) or chemical syn thesis. IVT is widely used to gen erate sgRNAs, since it can be easily performed in most labs.

关键词： In vitro clustered regularly specific genomic

Nanotechnology based CRISPR/Cas9 system delivery for genome editing:Progress and prospect

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Nano Research 2019年第10期12卷 2437-2450页

作者： Huan Deng Wei Huang Zhiping Zhang Tongji School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Center for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

The genome editing tool,clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9 system,has achieved successful therapeutic efficacy via precise modification of the genome and exceeded previous genome engineering methods owing to its versatility and simplicity.Rapid expansion in biomedical research has benefited from this newly emerged technique,such as genetic diseases treatment,cancer characterization,and plant improvement.However,the key challenge is efficient delivery of CRISPR components in vivo and nanotechnology plays an in dispensable role in non viral gene delivery.In this review,we will first briefly describe the mechanism and delivery strategies of CRISPR/Cas9 system.Furthermore,the past and current researches of nan oparticles based CRISPR/Cas9 system delivery for genome editi ng will be highlighted.Fin ally,we will discuss the challe nges and prospects of CRISPR/Cas9 system combi ned with nano tech no logy for clinical translation in the future.

关键词： clustered regularly in terspaced short palindromic repeats(CRISPR)/Cas9 genome editi ng nan oparticle polymer liposome

Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease

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World Journal of Gastroenterology 2019年第18期25卷 2177-2187页

作者： Viktor Limanskiy Arpita Vyas Lakshmi Shankar Chaturvedi Dinesh Vyas Department of Surgery San Joaquin General Hospital College of Medicine CNSU College of Medicine and College of Pharmacy California Northstate University

The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9(CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease(IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and biomedical research field. We are beginning to see its application in gene manipulation of sickle cell disease,human immunodeficiency virus resistant embryologic twin gene modification and IBD genes such as Gatm(Glycine amidinotransferase, mitochondrial),nucleotide-binding oligomerization domain-containing protein 2, KRT12 and other genes implicated in adaptive immune convergence pathways have been subjected to gene editing, however there are very few publications. Furthermore,since Crohn's disease and ulcerative colitis have shared disease susceptibility and share genetic gene profile, it is paramount and is more advantageous to use CRISPR technology to maximize impact. Although, currently CRISPR does have its limitations due to limited number of specific Cas enzymes, off-target activity,protospacer adjacent motifs and crossfire between different target sites. However,these limitations have given researchers further insight on how to augment and manipulate enzymes to enable precise gene excision and limit crossfire between target sites.

关键词： clustered regularly interspersed short palindromic repeats Inflammatory bowel disease Crohn’s disease Ulcerative colitis Gene excision Gene editing Gene therapy Financial impact of inflammatory bowel disease on healthcare clustered regularly interspersed short palindromic repeats crossfire

CRISPR-Cas System for RNA Detection and Imaging

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Chemical Research in Chinese Universities 2020年第2期36卷 157-163页

作者： CHEN Siyu WANG Rujia LEI Chunvang NIE Zhou State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan Provincial Key Laboratory of Bioniacromolecular Chemical BiologyHunan UniversityChangsha 410082P.R.China

The system of clustered regularly interspaced short palindromic repeats(CRISPR)and CRISPR-associated endonucleases(Cas)have been widely used in gene editing,disease treatment,molecular diagnosis and chromosome imaging.On account of the programmable target recognition of CRISPR-Cas system and the specific targeting function toward RNA of type Ⅵ class Ⅱ Cas proteins,CRISPR-Cas system has been deployed as RNA recognition and detection tools,exhibiting promising application potentials in the field of RNA detection and imaging.In this review,we summarize the latest research progresses as well as development prospects of CRISPR-Cas system in RNA diagnosis and live cell RNA imaging.

关键词： clustered regularly interspaced short palindromic repeats-associated endonucleases(CRISPR-Cas) RNA detection RNA imaging Collateral cleavage