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Effects of age and sex on clinical high-risk for psychosis in the community

World Journal of Psychiatry 2020年第5期10卷 101-124页

作者： Frauke Schultze-Lutter Benno G Schimmelmann Rahel Fluckiger Chantal Michel Department of Psychiatry and Psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40692Germany University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of BernBern 3000Switzerland University Hospital of Child and Adolescent Psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND Recent reports of both heightened prevalence rates and limited clinical relevance of clinical high-risk(CHR)criteria and their relevant symptoms in children and adolescents indicate an important role of neurodevelopment in the early detection of ***,sex effects in CHR symptoms have been reported,though studies were *** sex also impacts on neurodevelopment,we expected that sex might have an additional contribution to age in the prevalence and clinical relevance of CHR symptoms and *** To investigate age and sex effects on CHR criteria and symptoms and their association with psychosocial impairment and mental *** In this cross-sectional cohort study,n=29168-to 40-year-olds,randomly drawn from the population register of the Swiss canton Bern,were assessed in semistructured interviews by phone or face-to-face for CHR symptoms and criteria using the Structured Interview for Psychosis-risk Syndromes and the Schizophrenia Proneness Instrument in its child and youth,and adult version,***,social and occupational functioning and DSM-IV axis I disorders were *** and interaction effects of age and sex on CHR symptoms and criteria,and interaction effects of age,sex,and CHR symptoms and criteria on presentation of functional impairment and of non-psychotic disorder were investigated using logistic regression *** Altogether,542(18.6%)participants reported any CHR symptom;of these,261(9.0%)participants reported any one of the 11 criteria relevant cognitive and perceptual basic symptoms,and 381(13.1%)any one of the five attenuated or transient psychotic symptoms(attenuated psychotic symptoms/brief intermittent psychotic symptoms).Fewer participants met any one of the CHR criteria(n=82,2.8%)or any one of the three recently recommended CHR criteria(n=38,1.3%).Both age and sex were significantly(P<0.05)associated with CHR symptoms and criteria,mostly by younger age and female se

关键词： Psychosis clinical high-risk Attenuated psychotic symptoms Basic symptoms Community Age Sex Interview assessment Prevalence

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