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Evaluation of the clinical effects of atropine in combination with remifentanil in children undergoing surgery for acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2065-2072页

作者： Yu-Juan Li Yong-Yan Chen Xia-Lan Lin Wei-Zhi Zhang Department of Anesthesiology Shanxi Provincial Children’s HospitalTaiyuan 030013Shanxi ProvinceChina

BACKGROUND Acute appendicitis(AA)is the most common cause of acute abdomen in *** significantly influences the surgical treatment of AA in children,making the scientific and effective selection of anesthetics *** To assess the clinical effect of atropine(ATR)in combination with remifentanil(REMI)in children undergoing surgery for *** In total,108 cases of pediatric AA treated between May 2020 and May 2023 were selected,58 of which received ATR+REMI[research group(RG)]and 50 who received REMI[control group(CG)].Comparative analyses were conducted on the time to loss of eyelash reflex,pain resolution time,recovery time from anesthesia,incidence of adverse events(AEs;respiratory depression,hypoxemia,bradycardia,nausea and vomiting,and hypotension),intraoperative responses(head shaking,limb activity,orientation recovery,safe departure time from the operating room),hemodynamic parameters[oxygen saturation(SPO2),mean arterial pressure,heart rate,and respiratory rate],postoperative sedation score(Ramsay score),and pain level[the Face,Legs,Activity,Cry,Consolability(FLACC)Behavioral Scale].RESULTS Compared with the CG,the RG showed significantly shorter time to loss of eyelash reflex,pain resolution,recovery from anesthesia,and safe departure from the operating ***,the incidence rates of overall AEs(head shaking,limb activity,etc.)were lower,and influences on intraoperative hemodynamic parameters and stress response indexes were *** Ramsay score at 30 min after extubation and the FLACC score at 60 min after extubation were significantly lower in the RG than in the *** ATR+REMI is superior to REMI alone in children undergoing AA surgery,with a lower incidence of AEs,fewer influences on hemodynamics and stress responses,and better post-anesthesia recovery.

关键词： Atropine Remifentanil Pediatric acute appendicitis Surgery clinical efficacy

Evaluation of oxaliplatin and tigio combination therapy in locally advanced gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1709-1716页

作者： Teng Wang Li-Yun Zhang Department of Gastroenterology Xianyang HospitalYan’an UniversityXianyang 712000Shaanxi ProvinceChina

BACKGROUND Locally advanced gastric cancer(LAGC)is a common malignant *** recent years,neoadjuvant chemotherapy has gradually become popular for the treatment of *** To investigate the efficacy of oxaliplatin combined with a tigio neoadjuvant chemotherapy regimen vs a conventional chemotherapy regimen for *** Ninety patients with LAGC were selected and randomly divided into control and study groups with 45 patients in each group,according to the numerical table *** control group was treated with conventional chemotherapy,and the study group was treated with oxaliplatin combined with tigio-neoadjuvant *** primary outcome measures were the clinical objective response rate(ORR)and surgical resection rate(SRR),whereas the secondary outcome measures were safety and Karnofsky Performance Status *** The ORR in the study group was 80.00%,which was significantly higher than that of the control group(57.78%).In the study group,SRR was 75.56%,which was significantly higher than that of the control group(57.78%).There were 15.56%adverse reactions in the study group and 35.56%in the control *** differences were statistically significant between the two *** The combination of oxaliplatin and tigio before surgery as neoadjuvant chemotherapy for patients with LAGC can effectively improve the ORR and SRR and is safe.

关键词： Locally advanced gastric cancer Oxaliplatin and tigio Neoadjuvant chemotherapy Surgical resection rate Objective response rate clinical efficacy

Alzheimer's disease with depressive symptoms: clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation

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World Journal of Psychiatry 2024年第8期14卷 1216-1223页

作者： Xin Jin Chun-Yun Xu Jin-Feng Fei Yu Fang Cong-Hao Sun Department of Psychiatry Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the *** several treatment methods exist,their efficacy is *** recent years,repetitive transcranial magnetic stimulation(rTMS)utilizing the theta burst stimulation(TBS)mode,specifically the intermittent TBS(iTBS),has demonstrated promising therapeutic potential in the management of neuropsychiatric *** To examine the therapeutic efficacy of iTBS mode of rTMS for treating depressive symptoms in patients with *** This retrospective study enrolled 105 individuals diagnosed with AD with depressive symptoms at Huzhou Third Municipal Hospital,affiliated with Huzhou University,between January 2020 and December *** received standard pharmacological interventions and were categorized into control(n=53)and observation(n=52)groups based on treatment *** observation group received iTBS mode of rTMS,while the control group received pseudo-stimulation.A comparative analysis evaluated psychological well-being,adverse events,and therapeutic at initiation of hospitalization(T0)and 15 days post-treatment(T1).RESULTS At T1,both groups exhibited a marked reduction in self-rating depression scale and Hamilton depression scale scores compared to ***,the observa-tion group showed a more pronounced decrease than the control *** T1,the Mini-mental state examination scores for both groups had increased markedly from their initial T0 ***,the increase was particularly more substantial in the observation group than in the control *** patients in the control group had ineffective treatment effects,while five patients in the observation group experienced the ***,the observation group experienced a substantially reduced incidence of ineffective treatment as compared to th

关键词： Alzheimer's disease Non-persistentθshort array fast pulse mode Depression clinical efficacy Dementia Repetitive transcranial magnetic stimulation

Radiofrequency ablation combined with transcatheter arterial chemoembolization for recurrent liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1756-1764页

作者： Jin-You Guo Li-Li Zhao Hui-Jun Cai Hui Zeng Wei-Dong Mei Department of Oncology The Second People's Hospital of Zhejiang Province Taizhou Yuhuan CityTaizhou 317605Zhejiang ProvinceChina Department of Interventional China's Zhejiang Province Tumor HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND The recurrence rate of liver cancer after surgery is *** ablation(RFA)combined with transcatheter arterial chemoembolization(TACE)is an effective treatment for liver cancer;however,its efficacy in recurrent liver cancer remains *** To investigate the clinical effect of TACE combined with RFA in the treatment of recurrent liver *** Ninety patients with recurrent liver cancer were divided into 2 groups according to treatment plan:Control(RFA alone);and experimental[TACE combined with RFA(TACE+RFA)].The incidence of increased alanine aminotransferase levels,complications,and other indices were compared between the two groups before and after the *** One month after the procedures,the short-term efficacy rate and Karnofsky Performance Status scores of the experimental group were significantly higher than those of the control group(P0.05).CONCLUSION TACE+RFA was effective for the treatment of recurrent liver cancer and significantly reduced AFP levels and improved various indices of liver function.

关键词： Transcatheter arterial chemoembolization Radiofrequency ablation Recurrent liver cancer clinical efficacy Overall response rate Disease control rate

Comparison of the clinical effects of dual-modality endoscopy and traditional laparotomy for the treatment of intra-and extrahepatic bile duct stones

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 759-767页

作者： Wei Wang Hui Xia Bin Dai Department of Hepatobiliary Surgery Wuhan No.1 HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND Bile duct stones(BDSs)may cause patients to develop liver cirrhosis or even liver ***,the success rate of surgical treatment for intrahepatic and extrahepatic BDSs is not satisfactory,and there is a risk of postoperative *** To compare the clinical effects of dual-modality endoscopy(duodenoscopy and laparoscopy)with those of traditional laparotomy in the treatment of intra-and extrahepatic *** Ninety-five patients with intra-and extrahepatic BDSs who sought medical services at Wuhan No.1 Hospital between August 2019 and May 2023 were selected;45 patients in the control group were treated by traditional laparotomy,and 50 patients in the research group were treated by dual-modality *** following factors were collected for analysis:curative effects,safety(incision infection,biliary fistula,lung infection,hemobilia),surgical factors[surgery time,intraoperative blood loss(IBL)volume,gastrointestinal function recovery time,and length of hospital stay],serum inflammatory markers[tumor necrosis factor(TNF)-α,interleukin(IL)-6,and IL-8],and oxidative stress[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),malondialdehyde(MDA),and advanced protein oxidation products(AOPPs)].RESULTS The analysis revealed markedly better efficacy(an obviously higher total effective rate)in the research group than in the control *** addition,an evidently lower postoperative complication rate,shorter surgical duration,gastrointestinal function recovery time and hospital stay,and lower IBL volume were observed in the research ***,the posttreatment serum inflammatory marker(TNF-α,IL-6,and IL-8)levels were significantly lower in the research group than in the control *** with those in the control group,the posttreatment GSH-Px,SOD,MDA and AOPPs in the research group were equivalent to the pretreatment levels;for example,the GSH-Px and SOD levels were significantly higher,while the MDA and AOPP levels were

关键词： Dual-modality endoscopy Traditional laparotomy Intra-and extrahepatic bile duct stones clinical efficacy

Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations

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Precision clinical Medicine 2019年第4期2卷 235-245页

作者： Guodai Hong Xuemei Chen Xizhuo Sun Meiling Zhou Bing Liu ZhuLi Zhendong Yu Wenbin Gao Tao Liu Department of Biotherapy and Oncology Shenzhen Luohu People’s HospitalThe Third Affiliated Hospital(The Affiliated Luohu Hospital)of Shenzhen UniversityShenzhen 518001China The Key Laboratory of Biomedical Information Engineering of the Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Public Service Platform for Cell Quality Testing and Evaluation of Shenzhen Shenzhen 518001China Central Laboratory Peking University Shenzhen HospitalShenzhen 518036China

This study investigated the efficiency of natural killer(NK)cell immunotherapy on non-small cell lung cancer with and without EGFRmutations in order to evaluate the response rate(RR)and progression-free survival(PFS).Among the 48 patients recruited,24 were clinically confirmed to be EGFR mutation *** study group was treated with autologous NK cell *** of the lymphocyte number,serum tumourrelated biomarkers,circulating tumour cells(CTC),Karnofsky Performance Status(KPS)and survival curves were carried out before and after NK cell *** safety and short-term effects were evaluated,followed by median PFS and RR *** serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group(pclinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.

关键词： Natural killer cells immunotherapy EGFR mutation lung cancer clinical efficacy clinical trial

Progress of Research on Organic Fibrosis with Traditional Chinese Medicine

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World Journal of Traditional Chinese Medicine 2016年第2期2卷 53-59页

作者： Qing-Lan Wang Xiao-Ning Wang Ping Liu E-Institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine Institute of Liver Diseases Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine

Fibrosis is the remodeling and repair processes of chronic injuries. There are few effective therapies. Chinese medicine formula, the main pattern of traditional Chinese medicine(TCM) in clinic, applies a multi-component, multi-target and complicated approach in the treatment of diseases, and certainly shows good comprehensive therapeutic effects on fibrosis. In this review, the clinical study, effects and mechanism of action of Fuzheng Huayu recipe in the treatment of liver, pulmonary, and renal fibrosis was analyzed and evaluated. Meanwhile, based on the understanding of TCM pathogenesis for liver cirrhosis, this review will also briefly introduce the research of different classical Chinese medicine formulae with various functions in the treatment of experimental liver fibrosis induced by different methods, including comparing the efficacy, analyzing the action characteristics and mechanism of effective formulae, exploring pathological and biological basis of TCM diagnostic and therapeutic pattern, which will contribute to the research of TCM in the treatment of organ fibrosis.

关键词： Organic fibrosis traditional Chinese medicine(TCM) clinical efficacy Fuzheng Huayu recipe

Effect of Acupoints on Acupuncture-Moxibustion and its Therapeutic Mechanism

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World Journal of Traditional Chinese Medicine 2020年第3期6卷 239-248页

作者： Han-Dan Zheng Zhao-Qin Wang Shan-Shan Li Yuan Lu Yan Huang Ci-Li Zhou Yu-Qing Lu Hui-Rong Liu Ya-Nan Liu Huan-Gan Wu Key Laboratory of Acupuncture and Immunological Effects Shanghai Research Institute of Acupuncture and MeridianShanghai University of Traditional Chinese Medicine Yueyang clinical Medical College Shanghai University of Traditional Chinese Medicine Department of Acupuncture and Moxibustion Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

The clinical efficacy of acupuncture-moxibustion(AM)mainly depends on acupoints,but the relationship between the acupoints and AM remains *** clinical efficacy and clarifying the mechanisms of AM is *** found that the specificity and sensitivity of acupoints,the skill of operation,and reasonable amount of stimulation can significantly improve the efficacy of *** addition,some studies have shown that Neural-Endocrine-Immune network and metabolites are involved in this process,clarifying the therapeutic mechanism of ***,how to effectively use acupoints to improve the clinical efficacy of AM is one of the key issues in need of an urgent *** summary,this article reviewed the Chinese and English databases on the clinical efficacy and underlying mechanisms of acupoints to clarify the relationship between acupoints and AM efficacy and ultimately improve clinical efficacy through effective and rational use of acupoints.

关键词： Acupoints clinical efficacy acupuncture-moxibustion specificities neural-endocrine-immune network

Traditional Chinese Medicines Against COVID‑19:A Global Overview

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 279-313页

作者： Chang‑Liang Yao Wen‑Long Wei Jian‑Qing Zhang Qi‑Rui Bi Jia‑Yuan Li Ikhlas Khan Rudolf Bauer De‑An Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory Research Center for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina National Center for Natural Products Research School of PharmacyUniversity of MississippiMSUSA Department of Pharmacognosy Institute of Pharmaceutical SciencesUniversity of GrazGrazAustria

Coronavirus disease 2019(COVID‑19),caused by the severe acute respiratory syndrome coronavirus 2,continues to be a global *** Chinese medicines(TCMs)are an important element of the fight against COVID‑19 in *** combined application of TCMs and conventional medicines in the treatment of COVID‑19 has achieved beneficial results,including the resolution of symptoms,prevention of disease progression,and reduced *** this review,we summarize and discuss the current applications of TCMs with respect to COVID‑19,as well as update the preclinical and clinical research,including chemical analysis,molecular mechanisms,quality control,drug development,and studies of clinical *** expectation is that a better understanding of the roles of TCMs against COVID‑19 will improve the response to COVID‑19,both in China and globally.

关键词： Coronavirus disease 2019 clinical efficacy molecular mechanism traditional Chinese medicine