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clinical efficacy of integral theory–guided laparoscopic integral pelvic floor/ligament repair in the treatment of internal rectal prolapse in females

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World Journal of clinical Cases 2020年第23期8卷 5876-5886页

作者： Yang Yang Yong-Li Cao Yuan-Yao Zhang Shou-Sen Shi Wei-Wei Yang Nan Zhao Bing-Bing Lyu Wen-Li Zhang Dong Wei Institute of Anal-Colorectal Surgery the 989 Hospital of The Joint Logistics Support Force of PLALuoyang 471031Henan ProvinceChina

BACKGROUND Internal rectal prolapse(IRP)is one of the most common causes of obstructive *** incidence of IRP in women is approximately three times that in *** is mainly treated by surgery,which can be divided into two categories:Abdominal procedures and perineal *** study offers a better procedure for the treatment of *** To compare the clinical efficacy of laparoscopic integral pelvic floor/ligament repair(IPFLR)combined with a procedure for prolapse and hemorrhoids(PPH)and the laparoscopic IPFLR alone in the treatment of IRP in *** This study collected the clinical data of 130 female patients with IRP who underwent surgery from January 2012 to October *** patients were divided into groups A and *** A had 63 patients who underwent laparoscopic IPFLR alone,and group B had 67 patients who underwent the laparoscopic IPFLR combined with *** degree of internal rectal prolapse(DIRP),Wexner constipation scale(WCS)score,Wexner incontinence scale(WIS)score,and Gastrointestinal Quality of Life Index(GIQLI)score were compared between groups and within groups before surgery and 6 mo and 2 years after *** All laparoscopic surgeries were *** general information,number of bowel movements before surgery,DIRP,GIQLI score,WIS score,and WCS score before surgery were not significantly different between the two groups(all P>0.05).The WCS score,WIS score,GIQLI score,and DIRP in each group 6 mo,and 2 years after surgery were significantly better than before surgery(P<0.001).In group A,the DIRP and WCS score gradually improved from 6 mo to 2 years after surgery(P<0.001),and the GIQLI score progressively improved from 6 mo to 2 years after surgery(P<0.05).In group B,the DIRP,WCS score and WIS score significantly improved from 6 mo to 2 years after surgery(P<0.05),and the GIQLI score 2 years after surgery was significantly higher than that 6 mo after surgery(P<0.05).The WCS score,WIS score,GIQLI score,and DIRP of

关键词： Internal rectal prolapse Integral theory Integral pelvic floor/Ligament repair Procedure for prolapse and hemorrhoids clinical efficacy Minimally invasive surgery for treatment of constipation

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clinical efficacy and prognostic risk factors of endoscopic radiofrequency ablation for gastric low-grade intraepithelial neoplasia

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 724-733页

作者： Nan-Jun Wang Ning-Li Chai Xiao-Wei Tang Long-Song Li Wen-Gang Zhang En-Qiang Linghu Department of Gastroenterology and Hepatology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND The use of radiofrequency ablation(RFA)has been reported in the treatment of gastric low-grade intraepithelial neoplasia(LGIN).However,its efficacy and prognostic risk factors have not been well *** To explore the efficacy and prognostic risk factors of RFA for gastric LGIN in a large,long-term follow-up clinical *** The clinical data of 271 consecutive cases from 198 patients who received RFA for treatment of gastric LGIN at the Chinese PLA General Hospital from October 2014 to October 2020 were reviewed in this retrospective *** on operative parameters,complications,and follow-up outcomes including curative rates were recorded and *** The curative rates of endoscopic RFA for gastric LGIN at 3 mo,6 mo,and 1-5 years after the operation were 93.3%,92.8%,91.5%,90.3%,88.5%,85.7%,and 83.3%,*** analyses revealed that Helicobacter pylori(***)infection and disease duration>1 year had a significant effect on the curative rate(P1 year may be the main risk factors for relapse of LGIN after RFA.

关键词： Endoscopic radiofrequency ablation Gastric low-grade intraepithelial neoplasia clinical efficacy Prognostic risk factors

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clinical efficacy of total laparoscopic splenectomy for portal hypertension and its influence on hepatic hemodynamics and liver function

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1684-1692页

作者： Rui-Zhao Qi Zhi-Wei Li Zheng-Yao Chang Wei-Hua Chang Wen-Lei Zhao Chuan Pang Ying Zhang Xing-Long Hu Feng Liang Department of General Surgery 5th Medical CenterChinese PLA General HospitalBeijing 100039China Department of Hepatobiliary The 3rd People’s Hospital of ShenzhenShenzhen 518112Guangdong ProvinceChina

BACKGROUND The liver hemodynamic changes caused by portal hypertension(PH)are closely related to various complications such as gastroesophageal varices and portosystemic shunts,which may lead to adverse clinical outcomes in these patients,so it is of great clinical significance to find treatment strategies with favorable clinical efficacy and low risk of *** To study the clinical efficacy of total laparoscopic splenectomy(TLS)for PH and its influence on hepatic hemodynamics and liver *** Among the 199 PH patients selected from October 2016 to October 2020,100 patients[observation group(OG)]were treated with TLS,while the remaining 99[reference group(RG)]were treated with open splenectomy(OS).We observed and compared the clinical efficacy,operation indexes[operative time(OT)and intraoperative bleeding volume],safety(intraperitoneal hemorrhage,ascitic fluid infection,eating disorders,liver insufficiency,and perioperative death),hepatic hemodynamics(diameter,velocity,and flow volume of the portal vein system),and liver function[serum alanine aminotransferase(ALT),serum aspartate aminotransferase(AST),and serum total bilirubin(TBil)]of the two *** The OT was significantly longer and intraoperative bleeding volume was significantly lesser in the OG than in the ***,the overall response rate,postoperative complications rate,and liver function indexes(ALT,AST,and TBil)did not differ significantly between the OG and *** hepatic hemodynamics statistics showed that the pre-and postoperative blood vessel diameters in the two cohorts did not differ *** the postoperative blood velocity and flow volume reduced significantly when compared with the preoperative values,there were no significant inter-group *** TLS contributes to comparable clinical efficacy,safety,hepatic hemodynamics,and liver function as those of OS in treating PH,with a longer OT but lesser intraoperative blood loss.

关键词： Total laparoscopic splenectomy Open splenectomy Portal hypertension clinical efficacy Hepatic hemodynamics and liver function

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clinical efficacy of laparoscopic cholecystectomy plus cholangioscopy for the treatment of cholecystolithiasis combined with choledocholithiasis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2080-2087页

作者： Chao-Hui Liu Zhi-Wei Chen Zhe Yu Hong-Yu Liu Jian-Sheng Pan Shuang-Shuang Qiu Department of General Surgery The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)Quanzhou 362000Fujian ProvinceChina Department of General Surgery Anxi Hospital of Traditional Chinese MedicineQuanzhou 362499Fujian ProvinceChina

BACKGROUND Currently,endoscopic retrograde cholangiopancreatography(ERCP)plus laparoscopic cholecystectomy(LC)is the main treatment for cholecystolithiasis combined with ***,the treatment is unsatisfactory,and the development of better therapies is *** To determine the clinical efficacy of LC plus cholangioscopy for cholecystolithiasis combined with *** Patients(n=243)with cholecystolithiasis and choledocholithiasis admitted to The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)between January 2019 and December 2023 were included in the study;111 patients(control group)underwent ERCP+LC and 132 patients(observation group)underwent LC+laparoscopic common bile duct exploration(LCBDE).Surgical success rates,residual stone rates,complications(pancreatitis,hyperamylasemia,biliary tract infection,and bile leakage),surgical indicators[intraoperative blood loss(IBL)and operation time(OT)],recovery indices(postoperative exhaust/defecation time and hospital stay),and serum inflammatory markers[C-reactive protein(CRP)],tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were *** No significant differences in surgical success rates and residual stone rates were detected between the observation and control ***,the complication rate,IBL,OT,postoperative exhaust/defecation time,and hospital stays were significantly reduced in the observation group compared with the control ***,CRP,TNF-α,and IL-6 Levels after treatment were reduced in the observation group compared with the levels in the control *** These results indicate that LC+LCBDE is safer than ERCP+LC for the treatment of cholecystolithiasis combined with *** surgical risks and postoperative complications were lower in the observation group compared with the control ***,patients may recover quickly with less inflammation after LCBDE.

关键词： Laparoscopic common bile duct exploration Endoscopic retrograde cholangiopancreatography Laparoscopic cholecystectomy Cholecystolithiasis Choledocholithiasis clinical efficacy

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Safety and clinical efficacy of granulocyte and monocyte adsorptive apheresis therapy for ulcerative colitis

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World Journal of Gastroenterology 2006年第4期12卷 520-525页

作者： TakayukiYamamoto SatoruUmegae KoichiMatsumoto Inflammatory Bowel Disease Center Yokkaichi Social Insurance Hospital10-8 HazuyamachoYokkaichiMie 510-0016Japan

Active ulcerative colitis （UC） is frequently associated with infiltration of a large number of leukocytes into the bowel mucosa. Therefore, removal of activated circulating leukocytes by apheresis has the potential for improving UC. In Japan, since April 2000, leukocytapheresis using Adacolumn has been approved as the treatment for active UC by the Ministry of Health and Welfare. The Adacolumn is an extracorporeal leukocyte apheresis device filled with cellulose acetate beads, and selectively adsorbs granulocytes and monocytes/macrophages. To assess the safety and clinical efficacy of granulocyte and monocyte adsorptive apheresis （GMCAP） for UC, we reviewed 10 open trials of the use of GMCAP to treat UC. One apheresis session （session time, 60 min） per week for five consecutive weeks （a total of five apheresis sessions） has been a standard protocol. Several studies used modified protocols with two sessions per week, with 90-min session, or with a total of 10 apheresis sessions. Typical adverse reactions were dizziness, nausea, headache, flushing, and fever. No serious adverse effects were reported during and after GMCAP therapy, and almost all the patients could complete the treatment course. GMCAP is safe and well-tolerated. In the majority of patients, GMCAP therapy achieved clinical remission or improvement. GMCAP is a useful alternative therapy for patients with steroid-refractory or -dependent UC. GMCAP should have the potential to allow tapering the dose of steroids, and is useful for shortening the time to remission and avoiding re-administration of steroids at the time of relapse. Furthermore, GMCAP may have efficacy as the first-line therapy for steroid-naive patients or patients who have the first attack of UC. However, most of the previous studies were uncontrolled trials. To assess a definite efficacy of GMCAP, randomized, doubleblind, sham-controlled trials are necessary. A serious problem with GMCAP is cost; a single session costs ￥145 000 （$1 300）. Ho

关键词： clinical efficacy Granulocyte and monocyte adsorptive apheresis Leukocytapheresis Safety Ulcerative colitis

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Analysis of the value and safety of thyroid-stimulating hormone in the clinical efficacy of patients with thyroid cancer

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World Journal of clinical Cases 2023年第5期11卷 1058-1067页

作者： Jian-Jing Liang Wen-Jing Feng Ru Li Run-Tao Xu Yu-Long Liang Department of Medicine Hebei UniversityBaoding 071000Hebei ProvinceChina Department of General Surgery the Third Hospital of Hebei Medical UniversityShijiazhuang 050051Hebei ProvinceChina Department of Cardiology First Hospital of Xinji CityXinji 052300Hebei ProvinceChina

BACKGROUND Thyroid cancer(TC)is a common malignant tumor in the endocrine *** recent years,the incidence and recurrence rates of TC have been raising due to increasing work pressure and irregular ***-stimulating hormone(TSH)is a specific parameter for thyroid function *** study aims to explore the clinical value of TSH in regulating the progression of TC,so as to find a breakthrough for the early diagnosis and treatment of *** To explore the value and safety of TSH in the clinical efficacy of patients with *** 75 patients with TC admitted to the Department of Thyroid and Breast Surgery of our hospital from September 2019 to September 2021 were selected as the observation group,and 50 healthy subjects were selected as the control group during the same *** control group was treated with conventional thyroid replacement therapy,and the observation group was treated with TSH suppression *** soluble interleukin(IL)-2 receptor(sIL-2R),IL-17,IL-35levels,free triiodothyronine(FT3),free tetraiodothyronine(FT4),CD3+,CD4+,CD8+,CD44V6,and tumor supplied group of factor(TSGF)levels were observed in the two *** occurrence of adverse reactions was compared between the two *** After treatment with different therapies,the levels of FT3,FT4,CD3+,and CD4+in the observation group and the control group were higher than those before treatment,while the levels of CD8+,CD44V6,and TSGF were lower than those before treatment,and the differences were statistically significant(P<0.05).More importantly,the levels of sIL-2R and IL-17 in the observation group were lower than those in the control group after 4 wk of treatment,while the levels of IL-35 were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of FT3,FT4,CD3+,and CD4+in the observation group were higher than those in the control group,and the levels of CD8+,CD44V6,and TSGF were lower than those in the co

关键词： Thyroid-stimulating hormone Thyroid cancer clinical efficacy Safety profile

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Robotic-assisted low anterior resection for rectal cancer shows similar clinical efficacy to laparoscopic surgery: A propensity score matched study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1558-1570页

作者： Shen-Xiang Long Xin-Ning Wang Shu-Bo Tian Yu-Fang Bi Shen-Shuo Gao Yu Wang Xiao-Bo Guo Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Nursing The People’s Hospital of Zhangqiu AreaJinan 250200Shandong ProvinceChina Medical Center for Gastrointestinal Surgery Weifang People’s HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND Rectal cancer ranks as the second leading cause of cancer-related mortality worldwide,necessitating surgical resection as the sole treatment *** the years,there has been a growing adoption of minimally invasive surgical techni-ques such as robotic and laparoscopic *** surgery represents an innovative modality that effectively addresses the limitations associated with traditional laparoscopic *** previous studies have reported favo-rable perioperative outcomes for robot-assisted radical resection in rectal cancer patients,further evidence regarding its oncological safety is still *** To conduct a comparative analysis of perioperative and oncological outcomes between robot-assisted and laparoscopic-assisted low anterior resection(LALAR)*** The clinical data of 125 patients who underwent robot-assisted low anterior resection(RALAR)and 279 patients who underwent LALAR resection at Shandong Provincial Hospital Affiliated to Shandong First Medical University from December 2019 to November 2022 were retrospectively *** performing a 1:1 propensity score matching,the patients were divided into two groups:The RALAR group and the LALAR group(111 cases in each group).Subsequently,a comparison was made between the short-term outcomes within 30 d after surgery and the 3-year survival outcomes of these two *** Compared to the LALAR group,the RALAR group exhibited a significantly earlier time to first flatus[2(2-2)d vs 3(3-3)d,P=0.000],as well as a shorter time to first fluid diet[4(3-4)d vs 5(4-6)d,P=0.001].Additionally,the RALAR group demonstrated reduced postoperative indwelling catheter time[2(1-3)d vs 4(3-5)d,P=0.000]and decreased length of hospital stay after surgery[5(5-7)d vs 7(6-8)d,P=0.009].Moreover,there was an observed increase in total cost of hospitalization for the RALAR group compared to the LALAR group[10777(10780-11850)dollars vs 10550(8766-11715)dollars,P=0.012].No signi

关键词： Rectal cancer Robotic surgical procedures Laparoscopy Low anterior resection clinical efficacy

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clinical efficacy of rosuvastatin in lipid management in Chinese patients in Hong Kong

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Chinese Medical Journal 2009年第23期122卷 2814-2819页

作者： Vivian W.Y. Lee T.S. Chau Vice EH. Leung Kenneth K.C. Lee Brian Tomlinson School of Pharmacy Faculty of Medicine The Chinese University of Hong Kong Hong Kong China Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China

Background Rosuvastatin has been claimed to be more potent than other statins in its ability to lower the low-density lipoprotein （LDL） cholesterol levels. This study aimed to investigate the clinical efficacy of rosuvastatin in LDL cholesterol lowering therapy for new or switched hyperlipidaemic Chinese patients. Methods This study was a retrospective one in patients who took rosuvastatin in the outpatient clinics of Prince of Wales Hospital during the period of July 1,2004 to June 30, 2005. The prescribing pattern, the utilization pattern and the side effect profile were recorded. Attainment of lipid goals for each patient was assessed according to the National Cholesterol Education Program Adult Treatment Panel （NCEP ATP） III guidelines. Results A total of 261 Chinese patients （mean age （64.8±12） years; 55.6% male） were recruited into the study. The mean LDL-cholesterol level was （3.50±1.29） mmol/L prior to Rosuvastatin and （2.30±1.73） mmol/L after Rosuvastatin treatment （P 〈0.0001）. Rosuvastatin raised the LDL-cholesterol goal achievement rate from 28.0% to 74.3% in all patients combined （P 〈0.0001） and from 11.0% to 79.0% for statin naive patients （P 〈0.0001）. Approximately 4% of patients developed side effects including myalgia, elevated liver enzymes, and dizziness. Conclusion Rosuvastatin was effective in improving LDL-cholesterol goal attainment and lowering LDL-cholesterol and triglyceride （TG） levels in either newly started or switched patients.

关键词： cholesterol rosuvastatin clinical efficacy

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Compare clinical efficacy and safety of neoadjuvant therapy and neoadjuvant chemoradiotherapy for locally advanced rectal cancer: Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1845-1856页

作者： Ying Wang Yan Yang Qi-Qi Liu Shao-Zhao Wang Department of Anus Intestinal Surgery Feicheng People’s HospitalFeicheng 271600Shandong ProvinceChina Department of Gastroenterology Qingdao Hospital of University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266011Shandong ProvinceChina Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Anorectal Words Central Hospital Affiliated Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND To compare the efficacy and safety of total neoadjuvant therapy(TNT)and neoadjuvant chemoradiotherapy(nCRT)in the treatment of middle and low locally advanced rectal *** study will systematically collect and integrate studies to evaluate the ability of these two treatments to improve tumor shrinkage rates,surgical resection rates,tumor-free survival,and severe adverse *** To provide clinicians and patients with more reliable treatment options to optimize treatment outcomes and quality of life for patients with locally advanced rectal cancer by comparing the advantages and disadvantages of the two treatment *** A full search of all clinical studies on the effectiveness and safety of TNT and nCRT for treating locally advanced rectal cancer identified in Chinese(CNKI,Wanfang,China Biomedical Literature Database)and English(PubMed,Embase)databases was *** system assessors independently screened the studies according to the inclusion and exclusion *** evaluation and RESULTS Finally,14 studies were included,six of which were randomized controlled studies.A total of 3797 patients were included,including 1865 in the TNT group and 1932 in the nCRT *** two sets of baseline data were *** results of the meta-analysis showed that the pCR rate[odds ratio(OR)=1.57,95%confidence interval(CI):1.30-1.90,Pclinical efficacy and safety than nCRT in the treatment of locally advanced rectal cancer.

关键词： Neoadjuvant therapy Neoadjuvant chemoradiotherapy Advanced rectal cancer clinical efficacy Meta-analysis

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clinical efficacy of Metoprolol Succinate Extended-Release Tablets in the Treatment of Post-Myocardial Infarction Ventricular Arrhythmias

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Journal of clinical and Nursing Research 2024年第8期8卷 169-174页

作者： Hongrun Gao Xiaohua Zhu Lin Guo Department of Emergency Wangdu County HospitalBaoding 072450Hebei ProvinceChina

Objective:To investigate the clinical efficacy of metoprolol succinate extended-release tablets in the treatment of post-myocardial infarction ventricular ***:The clinical data of 84 patients with post-myocardial infarction ventricular arrhythmia included in the study were collected and they were divided into Groups A and B with 42 cases each using the randomization *** A was treated with oral glucosamine hydrochloride,while Group B was administered oral metoprolol succinate extended-release *** indicators were used to evaluate the improvement of clinical indicators,therapeutic effects,and the incidence of adverse reactions in the two ***:The baseline data of the two groups of patients were not statistically significant(Pall>0.05);after treatment,the QT dispersion,corrected QT dispersion,and heart rate of Group B were lower than that of Group A(Pall=0.000clinical effectiveness of Group B was 95.24%,which was significantly higher than 80.95%in Group A(χ=4.087,P=0.043clinical effectiveness,and reduce the incidence of adverse reactions.

关键词： Metoprolol succinate Myocardial infarction Ventricular arrhythmia clinical efficacy

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