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Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development

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Cellular & Molecular Immunology 2021年第7期18卷 1692-1707页

作者： Mengyu Shi Ziyang Chen Meiqi Chen Jingping Liu Jing Li Zhe Xing Xiaogang Zhang Shuaijun Lv Xinyao Li Shaowen Zuo Shi Feng Ying Lin Gang Xiao Liping Wang Yumei He Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Department of Laboratory Medicine the Third Affiliated Hospital of Southern Medical UniversitySouthern Medical UniversityGuangzhouChina Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouChina The First Affiliated Hospital of Shenzhen University Reproductive Medicine CentreShenzhen Second People’s HospitalShenzhenChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Single Cell Technology and Application Southern Medical UniversityGuangzhouChina

The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful *** studies have shown that myeloid-derived suppressor cells(MDSCs)play an important role in maintaining feto-maternal tolerance,little is known about the role of MDSCs in pregnancies with intrauterine growth retardation(IUGR).Here,we reported that the activation of polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)during pregnancy was closely associated with fetal *** humans,class e scavenger receptor 1(SR-e1),a distinct marker for human PMN-MDSCs,was used to investigate PMN-MDSC function during *** activation of SR-e1+PMN-MDSCs was observed in all stages of pregnancy,accompanied by high cellular levels of ROS and arginase-1 activity,mediated through STAT6 ***,SR-e1+PMN-MDSCs in pregnancies with IUGR showed significantly lower suppressive activity,lower arginase-1 activity and ROS levels,and decreased STAT6 phosphorylation level,which were accompanied by an increase in inflammatory factors,compared with those in normal ***,the population of SR-e1+PMN-MDSCs was negatively correlated with the adverse outcomes of newborns from pregnancies with *** mice,decreases in cell population,suppressive activity,target expression levels,and STAT6 phosphorylation levels were also observed in the pregnancies with IUGR compared with the normal pregnancies,which were rescued by the adoptive transfer of PMN-MDSCs from pregnant ***,the growth-promoting factors(GPFs)secreted by placental PMN-MDSCs in both humans and mice play a vital role in fetal *** findings collectively support that PMN-MDSCs have another new role in pregnancy,which can improve adverse neonatal outcomes.

关键词： Polymorphonuclear myeloid-derived suppressor cells class e scavenger receptor 1 Immunotolerance

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