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Camganoids A and B,two new sesquiterpenes with different carbon skeletons isolated from fruits of cinnamomum migao

Chinese herbal Medicines 2022年第4期14卷 638-642页

作者： Yongzhen Xiao Ishaq Muhammad Xianpeng Ma huajun Yu Shikai Yan Xue Xiao huizi Jin Department of Natural Product Chemistry School of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Guizhou Jingcheng Pharmaceutical Co. Ltd.Guiyang 550200China Institute of Chinese Medicinal Sciences Guangdong Pharmaceutical UniversityGuangzhou 510006China

Objective:To isolate and identify the undescribed compounds from the fruits of cinnamomum migao and evaluate its nitric oxide inhibition ***:The chromatographic techniques of silica gel,Sephadex,and hPLC were used for isolation and purification of the compounds,while hR-ESI-MS,1D NMR,2D NMR,ECD,and X-ray diffraction techniques were used to characterize and confirm the isolated ***,the antiinflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAw264.7 cells stimulated by ***:Camganoid A(1),a novel sesquiterpene possessing an unprecedented skeleton,and camganoid B(2),containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton,were isolated and identified from the fruits of *** absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism(ECD)*** these compounds,compound 1 exhibited potent inhibitory activity against the production of nitric oxide with IC50value of 4.59μmol/L in RAw264.7 cells stimulated by ***:The isolation of two new skeletons from the fruits part of *** possessed unique skeletons which have not been reported before.

关键词： cinnamomum migao h.w.li nitric oxide inhibition sesquiterpene

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