Camganoids A and B,two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao

作     者：Yongzhen Xiao Ishaq Muhammad Xianpeng Ma Huajun Yu Shikai Yan Xue Xiao Huizi Jin Yongzhen Xiao;Ishaq Muhammad;Xianpeng Ma;Huajun Yu;Shikai Yan;Xue Xiao;Huizi Jin

作者机构：Department of Natural Product ChemistrySchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Guizhou Jingcheng Pharmaceutical Co.Ltd.Guiyang 550200China Institute of Chinese Medicinal SciencesGuangdong Pharmaceutical UniversityGuangzhou 510006China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2022年第14卷第4期

页      面：638-642页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by NSFC(81973191) Natural Science Foundation of Shanghai(19ZR1428100) Project supported by the Department of Science and Technology of Guizhou(Grant No.2831) the Horizontal Research Project of Shanghai Jiao Tong University(SA1700111,SA1700118) 

主　　题：Cinnamomum migao H.W.Li nitric oxide inhibition sesquiterpene 

摘      要：Objective:To isolate and identify the undescribed compounds from the fruits of Cinnamomum migao and evaluate its nitric oxide inhibition ***:The chromatographic techniques of silica gel,Sephadex,and HPLC were used for isolation and purification of the compounds,while HR-ESI-MS,1D NMR,2D NMR,ECD,and X-ray diffraction techniques were used to characterize and confirm the isolated ***,the antiinflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAW264.7 cells stimulated by ***:Camganoid A(1),a novel sesquiterpene possessing an unprecedented skeleton,and camganoid B(2),containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton,were isolated and identified from the fruits of *** absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism(ECD)*** these compounds,compound 1 exhibited potent inhibitory activity against the production of nitric oxide with IC50value of 4.59μmol/L in RAW264.7 cells stimulated by ***:The isolation of two new skeletons from the fruits part of *** possessed unique skeletons which have not been reported before.