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Rhythmic Profiles of Dihydropyrimidine Dehydrogenase,Thymidylate Synthase in mRNA Level and Whole Blood Reduced Glutathione Level on Healthy Volunteers and Nasopharyngeal Carcinoma Patients

Rhythmic Profiles of Dihydropyrimidine Dehydrogenase,Thymidy...

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药学发展前沿论坛及药理学博士论坛

作者： WU Ming-Wei ZENG Zhao-Lei LI Su GUO Ling QIU Fang XIAN Li-jian State Key Laboratory of Oncology in Southern China Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China

BACKGROUND & OBJECTIVE:Anti-cancer effect of 5-Fluorouracil (5-FU) is mediated mainly by inhibition of the thymidylate synthase (TS),while dihydropyrimidine dehydrogenase (DPD) is an initial and a rate-limiting catabolic enzyme of *** this study, the mRNA expression profiles of TS,DPD were investigated in both healthy volunteers and Nasopharyngeal Carcinoma (NPC) *** data will be useful to select special schedules of chrono-therapy for nasopharyngeal carcinoma ***:A total of 14 healthy volunteers and 13 NPC patients were involved in this *** venous blood was sampled every 4 hours during one 24-hour period starting at 12:00 *** circadian gene expression profiles of DPD,TS in PBMC were measured using the real-time quantitative RT-PCR *** whole blood reduced glutathione (GSH) concentration was determined by high performance liquid *** plasma cortisol concentration was determined by ***:Plasma cortisol levels of both groups displayed clear and similar circadian *** both groups,the plasma cortisol level peaked in the morning and was lowest at *** GSH concentrations showed statistically significant differences according to sampling time (ANOVA for Repeated Measures,F=5.182,P=0.024) in both *** present study,the Mesor (rhythm-adjust mean) level of DPD gene copies was 1.31×10±5.74×10 copy/μg RNA (mesor±SEM) in healthy volunteers,and it was 3.28×10±8.05×10 copy/μg RNA in NPC *** Mesor level of TS gene copies was 2.20×10±4.90×10 copy/μg RNA in healthy volunteers, and it was 8.28×10±1.66×10 copy/μg RNA in NPC *** was of statistical significance for DPD mRNA expression according to sampling time (ANOVA for Repeated Measures,F=8.225,P=0.002),but not fit for the cosinor curve(Cosinor,P>0.05).It was of no statistical significance for TS gene (ANOVA for Repeated Measures,F=3.489,P= 0.083;Cosinor,P>0.05).CONCLUSION:a clear circadian rhythm was not displayed

关键词： chrono-pharmacology Circadian rhythm Cortisol Glutathione Nasopharyngeal carcinoma

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Rhythmic Profiles of Dihydropyrimidine Dehydrogenase,Thymidylate Synthase and Whole Blood Reduced Glutathione Level in Healthy Volunteers and Nasopharyngeal Carcinoma Patients

Rhythmic Profiles of Dihydropyrimidine Dehydrogenase,Thymidy...

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2011医学科学前沿论坛第十二届全国肿瘤药理与化疗学术会议

作者： WU Ming-Wei,ZENG Zhao-Lei,LI Su,GUO Ling,QIU Fang,XIAN Li-Jian 1.State Key Laboratory of Oncology in Southern China 2.Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China

关键词： chrono-pharmacology Circadian rhythm Cortisol Glutathione Nasopharyngeal carcinoma

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