Rhythmic Profiles of Dihydropyrimidine Dehydrogenase,Thymidylate Synthase and Whole Blood Reduced Glutathione Level in Healthy Volunteers and Nasopharyngeal Carcinoma Patients

作     者：WU Ming-Wei,ZENG Zhao-Lei,LI Su,GUO Ling,QIU Fang,XIAN Li-Jian 1.State Key Laboratory of Oncology in Southern China 2.Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China 

会议名称：《2011医学科学前沿论坛第十二届全国肿瘤药理与化疗学术会议》

会议日期：2011年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

关 键 词：Chrono-pharmacology Circadian rhythm Cortisol Glutathione Nasopharyngeal carcinoma 

摘      要：BACKGROUND & OBJECTIVE:Anti-cancer effect of 5-Fluorouracil(5-FU) is mediated mainly by inhibition of the thymidylate synthase(TS),while dihydropyrimidine dehydrogenase(DPD) is an initial and a rate-limiting catabolic enzyme of *** this study,the mRNA expression profiles of TS,DPD were investigated in both healthy volunteers and Nasopharyngeal Carcinoma(NPC) *** data will be useful to select special schedules of chrono-therapy for nasopharyngeal carcinoma patients.