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Clinical Analysis of Acupuncture Combined with Acupoint Injection for the Treatment of chronic nonbacterial prostatitis

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Proceedings of Anticancer Research 2024年第5期8卷 76-81页

作者： Xizhe Sun Xiwen Yu Chen Fan Meixun Chen Na Dao Chengxin Hao Jiamei Wu Department of Traditional Chinese Medicine Baicheng Medical CollegeBaicheng 137000Jilin ProvinceChina Department of Basic Medical Science Baicheng Medical CollegeBaicheng 137000Jilin ProvinceChina

Objective:To evaluate the therapeutic effect of acupuncture combined with acupoint injection on chronic nonbacterial prostatitis(CNP).Methods:A total of 72 CNP patients admitted between March 2022 and October 2023 were *** patients were randomly divided into two groups using a random number *** combined treatment group(36 cases)received acupuncture combined with acupoint injection therapy,while the control group(36 cases)received conventional Western medicine *** overall efficacy rate,symptom severity,prostatic fluid indicators,incidence of adverse reactions,and recurrence rates were ***:The overall efficacy rate of the combined treatment group was higher than that of the control group(P<0.05).After 10 days of treatment,the symptom severity score of the combined treatment group was higher than that of the control group,and the prostatic fluid indicators were lower than those of the control group(P<0.05).The incidence of adverse reactions in the combined treatment group was lower than in the control group(P<0.05).During the follow-up period of 1-6 months,the recurrence rate in the combined treatment group was lower than that in the control group(P<0.05).Conclusion:Acupuncture combined with acupoint injection can alleviate CNP disease symptoms,improve prostate function,and prevent post-treatment adverse *** also has a lower recurrence risk and demonstrates excellent efficacy.

关键词： Acupuncture Acupoint injection chronic nonbacterial prostatitis Symptom severity Adverse reactions

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Electroacupuncture stimulating Zhongji(CV3),Guanyuan(CV4),and bilateral Dahe(KI12)attenuates inflammation in rats with chronic nonbacterial prostatitis induced by estradiol through inhibiting toll-like receptor 4 pathway

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中医杂志:英文版 2023年第5期43卷 963-972页

作者： LI Zhihao HAN Wenjun SONG Xiuling LI Yan CHEN Yuelai Department of Acupuncture-Moxibustion Tuina and TraumatologyShanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shool of MedicineShanghai 200233China Sleep Medical Center Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Andrology the Seventh People's Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Graduate School of Shanghai University of Traditional Chinese Medicine Shanghai 201203China

OBJECTIVE:To investigate the anti-inflammatory effect of electroacupuncture(EA)on chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS),also known as chronic nonbacterial prostatitis(CNP),and explore its underlying ***:A CNP rat was established by surgical castration combined with 17-βestradiol injection in male Sprague-Dawley rats for thirty consecutive *** CNP rats received EA treatment once a day for eight *** pelvic pain was evaluated by mechanical withdrawal threshold *** histological change was assessed by hematoxylin-eosin *** inflammatory cytokines in prostates were determined by enzyme-linked immunosorbent *** expressions of toll-like receptor 4(TLR4),myeloid differentiation factor 88(MyD88),inhibitors of kappa-B alpha(IκBα),and nuclear factor-kappa B(NF-κB)were detected by Western *** nuclear translocation of NF-κB and the location of TLR4 were observed with immunofluorescence ***:The results showed that EA decreased the prostate index,upregulated the mechanical withdrawal threshold,restored the histomorphology of the prostate,reduced the inflammatory factor levels,inhibited NF-κB p65 nuclear translocation,and downregulated the expression levels of critical proteins involved in the TLR4/NF-κB signaling pathway in ***:Our findings suggested that EA could relieve pelvic pain and attenuate prostatic inflammation in estradiol-induced CNP *** underlying mechanism may be related to the inhibition of the TLR4/NF-κB signaling pathway.

关键词： chronic nonbacterial prostatitis electroacupuncture morphology anti-inflammatory agents toll-like receptors

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Effectiveness and Safety of Umbilicus Treatment with Modified Dinggui Powder(加味丁桂散)in Patients with chronic nonbacterial prostatitis:A Randomized,Double-Blind,Placebo-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2021年第3期27卷 170-176页

作者： HUANG Hai ZHOU Min-jie WANG Ke-xie YU Chao WANG Yu-hang JI Jun PAN Wen YING Jian ZHAO Ling Department of Joint Surgery Guanghua HospitalShanghai University of Traditional Chinese MedicineShanghai200052China Department of Vasoular Surgery Shanghai Tradtional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200082China Department of Urology and An drology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Shanghai Qigong Research Institute Shanghai University of Traditional Chinese MedicineShanghai200030China School of Acupuncture-Moxbustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China

Objective:To evaluate the effectiveness and safety of Chinese herbal external umbilicus treatment with Modified Dinggui Powder(加味丁桂散,MDGP)in patients with chronic nonbacterial prostatitis(CNP).Methods:A randomized,double-blind,placebo-controlled clinical trial was conducted among 72 patients with *** were randomly allocated to a treatment group and a placebo group using computer software in a 1:1 ratio,and received either MDGP external umbilicus treatment(MDGP group,36 cases)or placebo(control group,36 cases)at acupoints Shenque(CV 8),twice a week for 4 *** addtion,patients all received herbal medicine treatment twice a day for 4 *** primary outcome was the US National Institutes of Health chronic prostatitis Symptom Scores Index(NIH-CPSI)with a questionnaire at weeks 2 and *** secondary outcomes including prostatic fluid examination(white blood cells and lecithin bodies),the clinical efficacy evaluation,and the adverse events were also assessed during the entire ***:The NIH-CPSI scores regarding pain or discomfort scores showed greater improvement in the MDGP group than placebo control group at weeks 2(P=0.001)and week 4(P=0.004),***-CPSI scores of symptom severity,total scores and leukocytes number in the prostatic fluid in the MDGP group were significantly improved(P0.05).The clinical effective rate was 73.53%(25/34)in the MDGP group,which was significally higher than the placebo control group with 48.39%(25/31,P<0.05).Patients were blinded successfully,and no serious adverse effects were found during the ***:A 4-week course of umbilicus treatment with modified Dinggui Powder seems to relieve pain and symptom severity effectively and increase the amount of leukocytes number in patients with CNP(Trial registration *** 800014687).

关键词： Modified Dinggui Powder umbilicus treatment chronic nonbacterial prostatitis randomized placebo-controlled trial

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Qinghua decoction(清化饮)improves chronic nonbacterial prostatitis possibly via regulating the chromogranin A/nerve growth factor/tyrosine kinase A signaling pathway mediated by inflammatory factors

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中医杂志:英文版 2023年第4期43卷 695-703页

作者： HAN Yunpeng YU Wentao ZHANG Ying XU Huazhou DENG Guoxing FANG Chaoyi School of Basic Medical Sciences Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Key Laboratory of Integrated Chinese and Western Medicine for Lung Disease Research Shijiazhuang 050091China

OBJECTIVE:To explore the mechanism by which Qinghua decoction(清化饮)regulates neuroendocrine inflammation in chronic nonbacterial prostatitis(CNP)model rats and provide an experimental basis for clinical ***:The rats were randomly divided into six groups:normal control,model,Qianlie Tongyu capsule,low-dose Qinghua decoction,medium-dose Qinghua decoction,and high-dose Qinghua decoction group with six rats in each *** in each group were sacrificed on the 29th day of treatment,and blood and prostate tissues were *** levels of tumor necrosis factor-alpha and interleukins 1-beta,6,8,and 10(TNF-αand IL-1β,-6,-8,and-10,respectively)were measured using enzyme-linked immunosorbent *** pathological changes in the rat prostate tissue in each group were observed under a light *** expression levels of chromogranin A(CgA),nerve growth factor(NGF),and tyrosine kinase A(TrkA)were detected using reverse transcription quantitative polymerase chain *** blotting was used to detect protein expression of CgA,NGF,and ***:In the model group,the prostate capsule membrane and stroma were significantly dilated with more inflammatory cells infiltrating the stroma and ***-α,IL-1β,-6,and-8,CgA,NGF,and TrkA levels increased,whereas the content of IL-10 decreased,which was statistically significant compared to that in the normal control group(P<0.05).Prostate tissue cells in the high-dose group were neatly arranged with no obvious inflammatory cell *** compared with the model group,the high-dose Qinghua decoction group showed a significant improvement in these indices(P<0.05).CONCLUSION:Qinghua decoction led to inhibition of pathological changes in the prostate tissue of rats with CNP,regulation of inflammatory cytokine expression,and inhibition in the expression of CgA,NGF,and *** mechanism may be primarily related to regulation of the CgA/NGF/TrkA signaling pathway mediated by various inflammato

关键词： inflammation interleukins chromogranin A nerve growth factor chronic nonbacterial prostatitis Qinghua decoction

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