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Animal Nutrition 2022年第4期11卷 228-241页

作者： Shanlong Tang Jingjing Xie Wei Fang Xiaobin Wen Chang Yin Qingshi Meng Ruqing Zhong Liang Chen Hongfu Zhang State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100093China Academy of State Administration of Grain Beijing100037China

Although high temperatures influence gut health,data on underlying mechanisms remains *** a pig model,this study performed a global analysis on how chronic heat stress affects the transport and immune function of the gut through transcriptome,proteome,microbial diversity and flow cytometry.A total of 27 pigs with similar body weights were assigned into 3 groups,control(Con)group(23℃),chronic heat stressed(HS)group(33°C),and pair-fed(PF)group,in a controlled environment for 21 *** results showed that pigs in the HS group had reduced growth performance and diminished height of ileal villi(Pchronic heart stress(Pheat stress-induced endoplasmic reticulum stress also increased the synthesis of misfolded proteins,leading to upregulation of misfolded protein degradation and synthesis,as well as vesicle transport disorder(Pchronic heat stress activated complement cascade response-related genes and proteins in the gut mucosa(Pchronic heat stress induced gut transport and immune function diso

关键词： chronic heat stress Gut transport and immunity Endoplasmic reticulum stress Growing pigs Multi-omics

Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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Animal Nutrition 2024年第1期16卷 363-375页

作者： Jinzhong Jing Jiayi Wang Xiaoyu Xiang Shenggang Yin Jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian Jingyi Cai Bo Kang Lianqiang Che Hua Zhao Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairsof Sichuan ProvinceAnimal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina College of Animal Science and Technology Sichuan Agricultural UniversityChengdu 611130SichuanChina

In the present study,the chronic heat stress(CHS)broiler model was developed to investigate the potential protection mechanism of organic selenium(selenomethionine,SeMet)on CHS-induced skeletal muscle growth retardation and poor meat *** hundred Arbor Acres male broilers(680±70 g,21 d old)were grouped into 5 treatments with 8 replicates of 10 broilers per *** in the control group were raised in a thermoneutral environment(22±2°C)and fed with a basal *** other four treatments were exposed to hyperthermic conditions(33±2°C,24 h in each day)and fed on the basal diet supplied with SeMet at 0.0,0.2,0.4,and 0.6 mg Se/kg,respectively,for 21 *** showed that CHS reduced(Pstress and endoplasmic reticulum(ER)stress in breast muscle,which increased(Pstress *** SeMet supplementation linearly increased(Pstress and ER ***'s more,SeMet suppressed protein degradation and improved protein biosynthesis though inhibiting the caspase and ubiquitin proteasome system and promoting the mTOR-4EBP1 *** conclusion,dietary SeMet supplementation increases the expression of several key selenoproteins

关键词： Broiler chronic heat stress Skeletal muscle Meat quality Mitochondrial dysfunction Endoplasmic reticulum stress

Selenogenome and AMPK signal insight into the protective effect of dietary selenium on chronic heat stress-induced hepatic metabolic disorder in growing pigs

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Journal of Animal Science and Biotechnology 2022年第1期13卷 152-165页

作者： Yan Liu Jiayong Tang Ying He Gang Jia Guangmang Liu Gang Tian Xiaoling Chen Jingyi Cai Bo Kang Hua Zhao Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory for Animal Disease-Resistance Nutrition Ministry of EducationHuimin RoadWenjiang DistrictChengdu 611130SichuanChina College of Animal Science and Technology Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background:chronic heat stress(CHS)disrupts hepatic metabolic homeostasis and jeopardizes product quality of ***(Se)may regulate the metabolic state through affect ***,we investigate the protective effect of dietary hydroxy-4-methylselenobutanoic acid(HMSeBA)on CHS induced hepatic metabolic disorder in growing pigs,and the corresponding response of ***:Forty crossbreed growing pigs were randomly assigned to five groups:control group raised in the thermoneutral environment(22±2℃)with basal diet;four CHS groups raised in hyperthermal condition(33±2℃)with basal diet and supplied with 0.0,0.2,0.4,and 0.6 mg Se/kg HMSeBA,*** trial lasted 28 *** serum biochemical,hepatic metabolism related enzyme,protein and gene expression and 25 selenoproteins in liver tissue were determined by real-time PCR,ELISA and western ***:CHS significantly increased the rectal temperature,respiration rate,serum aspartate aminotransferase(AST)and low-density lipoprotein cholesterol(LDL-C)of pigs,up-regulated hepatic heat shock protein 70(HSP70)and induced lower liver weight,glycogen content,hepatic glucokinase and glutathione peroxidase(GSH-Px).The CHSinduced liver metabolic disorder was associated with the aberrant expression of 6 metabolism-related gene and 11 selenoprotein encoding genes,and decreased the protein abundance of GCK,GPX4 and *** improved anti-oxidative capacity of liver.0.4 or 0.6 mg Se/kg HMSeBA supplementation recovered the liver weight,glycogen content and rescue of mRNA abundance of genes related to metabolism and protein levels of *** supplementation changed expressions of 15 selenoprotein encoding genes,and enhanced protein expression of GPX1,GPX4 and SELENOS in the liver affected by *** alone showed no impact while HMSeBA supplementation increased protein levels of p-AMPKαin the ***:In summary,HMSeBA supplementation beyond nutrient requirement mitigates CHS-induced hepati

关键词： chronic heat stress Hepatic metabolism HMSeBA Pigs Selenoprotein

Transcriptome analysis reveals the mechanism of chronic heat stress on meat quality of broilers

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Journal of Animal Science and Biotechnology 2023年第1期14卷 409-422页

作者： Zhen Liu Yingsen Liu Tong Xing Jiaolong Li Lin Zhang Yun Jiang Feng Gao College of Animal Science and Technology Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu ProvinceJiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety ControlNanjing Agricultural UniversityNo.1 WeigangWeigang 210095 NanjingChina. Institute of Agri‑Products Processing Jiangsu Academy of Agricultural SciencesNanjing 210014People’s Republic of China. School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210023People’s Republic of China.

Background:chronic heat stress has a negative impact on poultry meat *** this has been extensively investigated,previous studies have primarily focused on metabolic alterations and oxidative stress in the pectoralis major(PM)muscle under chronic heat stress,and not all of the underlying molecular mechanisms are completely ***:A total of 144 male Arbor Acres broilers(28 d old)were randomly allocated into 3 treatment groups:(1)the normal control(NC)group,with broilers raised at 22℃and fed a basal diet;(2)the heat stress(HS)group,with birds raised at 32℃and fed a basal diet;and(3)the pair-fed(PF)group,with birds raised at 22℃and fed the amount of feed equal to the feed consumed on the previous day by the HS *** experiment lasted for 14 ***:chronic heat stress decreased the average daily feed intake and average daily gain,increased feed:gain ratio(Pchronic heat stress decreased muscle fiber density,increased connective tissue,and led to intracellular *** transcriptome analyses indicated that the effect of chronic heat stress on meat quality was not only related to metabolism and oxidative stress,but also to signal transduction,immune system,transport and catabolism,cell growth and death,and muscle ***:chronic heat stress has a negative impact on the growth performance,meat quality,and the PM muscle structure of *** analysis revealed a comprehensive understanding of the mechanism of the chronic heat stress-induced deterioration of broiler meat quality at the transcriptional level.

关键词： chronic heat stress Meat quality Transcriptome

Metabonomics Approach to Understanding chronic heat stress in Rat Models

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Metabonomics Approach to Understanding Chronic Heat Stress i...