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Anionic structural effect in liquid–liquid separation of phenol from model oil by choline carboxylate ionic liquids

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Green Energy & Environment 2019年第2期4卷 131-138页

作者： Zhiyong Li Ruipeng Li Xiaoqing Yuan Yuanchao Pei Yuling Zhao Huiyong Wang Jianji Wang Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistry of Education School of Chemistry and Chemical Engineering Henan Normal University Henan Key Laboratory of Green Chemistry Henan Normal University

Phenolic compounds exist in crude oil as pollutants, and their removal is vital important for the refining and further application of oils. In traditional separation approaches, strong acid and strong base have to be used to remove these compounds, which may cause serious environmental problems. In this work, 19 kinds of cholinium ionic liquids have been developed to separate phenol from model oil by liquid–liquid extraction. Structural effect of anions of the ionic liquids in the separation is systematically investigated. It is found that depending on the chemical structure of ionic liquids, phenol can be removed from toluene with single-step removal efficiency from 86 to 99% under optimal conditions. The type of substituent groups and the-CH_2 number between two carboxylates have obvious effect on the removal efficiency, and more hydrophilic ionic liquids have a stronger extraction performance for phenol. Furthermore, thermodynamic,^(13) C NMR,~1 H NMR and density functional theory calculations have been performed to characterize the extraction process and to understand the extraction mechanism. It is shown that the extraction of phenol from oil to ionic liquid is a favorable process, and this process is mainly driven by enthalpy change. The formation of the hydrogen bond between anion of the ionic liquid and-OH of phenol is the main driving force for the extraction of phenol from oil to the ionic liquids.

关键词： Ionic liquid Extraction Phenol choline Hydrogen bonding

Dietary choline activates the Ampk/Srebp signaling pathway and decreases lipid levels in Pacific white shrimp(Litopenaeus vannamei)

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Animal Nutrition 2023年第4期15卷 58-70页

作者： Jingjing Lu Xinyue Tao Jiaxiang Luo Tingting Zhu Lefei Jiao Peng Sun Qicun Zhou Douglas R.Tocher Min Jin Laboratory of Fish and Shellfish Nutrition School of Marine SciencesNingbo UniversityNingbo 315211China Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantou 515063China

An 8-week feeding trial was conducted in Pacific white shrimp(Litopenaeus vannamei)to evaluate the effects of dietary choline supplementation on choline transport and metabolism,hepatopancreas histological structure and fatty acid profile,and regulation of lipid *** isonitrogenous and isolipidic diets were formulated to contain different choline levels of 2.91(basal diet),3.85,4.67,6.55,10.70 and 18.90 g/kg,respectively.A total of 960 shrimp(initial weight,1.38±0.01 g)were distributed randomly into twenty-four 250-L cylindrical fiber-glass tanks,with each diet assigned randomly to 4replicate *** results indicated that dietary choline significantly promoted the deposition of choline,betaine and carnitine(Pcholine *** contents of functional fatty acids in hepatopancreas,the activity of acetyl-CoA carboxylase(Acc),and the mRNA expression of fas,srebp and acc were highest in shrimp fed the diet containing 4.67 g/kg choline,and significantly higher than those fed the diet containing 2.91 g/kg,the lowest level of choline(Pcholine increased(Pcholine level increased(Pcholine promoted the deposition of choline and its metabolites by up-regulating genes related to choline transport and ***,appropriate dietary choline level promoted the development of hepatopancreas R cells and maintained the n

关键词： Pacific white shrimp choline Lipid Fatty acid Histology Ampk signaling pathway

Bioelectrochemical response of a choline biosensor fabricated by using polyaniline

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Science China Chemistry 2009年第12期52卷 2275-2280页

作者： DING ShouNian SHAN Dan SUN YueMing School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China School of Chemistry&Chemical Engineering Yangzhou UniversityYangzhou 225002China

On the basis of the isoelectric point of an enzyme and the doping principle of conducting polymers, choline oxidase was doped in a polyaniline film to form a biosensor. The amperometric detection of choline is based on the oxidation of the H2O2 enzymatically produced on the choline biosensor. The response current of the biosensor as a function of temperature was determined from 3 to 40°C. An apparent activation energy of 22.8 kJ·mol?1 was obtained. The biosensor had a wide linear response range from 5 × 10?7 to 1 × 10?4 M choline with a correlation coefficient of 0.9999 and a detection limit of 0.2 μM, and had a high sensitivity of 61.9 mA·M?1·cm?2 at 0.50 V and at pH 8.0. The apparent Michaelis constant and the optimum pH for the immobilized enzyme are 1.4 mM choline and 8.4, respectively, which are very close to those of choline oxidase in solution. The effect of selected organic compounds on the response of the choline biosensor was studied.

关键词： choline choline oxidase biosensor polyaniline matrix

The unmediated choline sensor based on layered double hydroxides in hydrogen peroxide detection mode

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Science China Chemistry 2009年第12期52卷 2281-2286页

作者： DING ShouNian SHAN Dan YAO WenJuan XUE HuaiGuo SUN YueMing COSNIER Serge School of Chemistry&Chemical Engineering Southeast UniversityNanjing 211189China Key Laboratory of Environmental Materials&Environmental Engineering of Jiangsu Province Yangzhou 225002China School of Chemistry&Chemical Engineering Yangzhou UniversityYangzhou 225002China Départment de Chimie Moléculaire UMR-5250 ICMG FR-2607CNRS UniversitéJoseph FouierBP-53Grenoble 38041France

In this work,we have developed a novel choline biosensor on the basis of immobilization of choline oxidase (ChOx) by the attractive materials layered double hydroxides (LDHs). Amperometric detection of choline was evaluated by holding the modified electrode at 0.5 V (vs. SCE). Due to the special properties of LDHs ([Zn3-Al-Cl]),such as chemical inertness,high porosity,and swelling property,the [Zn3-Al-Cl]/ChOx modified electrode exhibited an enhanced analytical performance. The biosensor provided a linear response to choline over a concentration range from 3.7 × 10-6 to 6.3 × 10-4 M with a low detection limit of 3 × 10-7 M based on S/N=3. The apparent Michaelis-Menten constant was calculated to be 1.38 mM. In addition,the interaction between ChOx and LDHs has also been investigated using FT-IR spectroscopy.

关键词： layered double hydroxides clay choline oxidase choline biosensor

Differential acetylcholine and choline concentrations in the cerebrospinal fluid of patients with Alzheimer’s disease and vascular dementia

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Chinese Medical Journal 2004年第8期117卷 1161-1164页

作者：贾建平贾健民周卫东徐敏楚长彪闫欣孙永馨 Department of Neurology Xuanwu Hospital Capital University of Medical SciencesBeijing100053China Department of Neurology First Hospital of Handan City Handan056002China

Background An important aspect of Alzheimer’s disease (AD) is loss or impairment of cholinergic neurons It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD) The purpose of this study was to explore the levels of ACh and choline (Ch) in the cerebrospinal fluid (CSF) of patients with AD and VD, and their possible relationship with cognitive impairment KH*2/5DMethods Twenty-two AD patients, twenty-two VD patients, and twenty normal controls were recruited and scored with a Mini-Mental State Examination (MMSE) CSF concentrations of ACh and Ch were measured using high-performance liquid chromatography with an electrochemical detector (HPLC-ECD) and the results were then compared to cognitive status Results ACh concentrations in CSF of AD patients [(10 7±5 1) nmol/L] and VD patients [(16 8±7 4) nmol/L] were both significantly lower than in controls [(34 5±9 0) nmol/L, t =10 67, P cholinesterase inhibitors may be h

关键词： acetylcholine choline cerebrospinal fluid Alzheimer’s disease vascular dementia

choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 393-411,I0001,I0002页

作者： Chen Wang Zhao-Yan Liu Wen-Ge Huang Zhi-Jun Yang Qiu-Ye Lan Ai-Ping Fang Meng-Jun Hou Xiao-Lin Luo Yao-Jun Zhang Si Chen Hui-Lian Zhu Department of Nutrition School of Public HealthSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouChina Center of Experimental Animals Sun Yat-sen UniversityGuangzhouChina Experimental and Teaching Center for Public Health School of Public HealthSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterGuangzhouChina

Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated *** evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and *** is an essential nutrient related to prolonged survival and reduced risk of ***,it remains unclear whether this phenomenon is mediated by ***:Two HCC cell lines(HUH-7 and Hep3B)were used in the present *** growth was evaluated by cell counting kit 8(CCK-8),colony formation,and in vivo mouse xenografts *** motility was calculated by wound healing and transwell *** were measured by transmission electron microscope(TEM),and autophagy flux was detected by mRFP-GFP-labeled LC3 *** mRNA level of genes was measured by quantitative real-time polymerase chain reaction(qRT-PCR).The protein levels were detected by Western blotting(WB).Results:We found that choline inhibited the proliferation,migration,and invasion of HCC cells by downregulating autophagy in vitro and in *** expression of the solute carrier family 5 member 7(SLC5A7),a specific choline transporter,correlated with better HCC *** further discovered that choline could promote SLC5A7 expression,upregulate cytoplasm p53 expression to impair the AMPK/mTOR pathway,and attenuate ***,we found that choline acted synergistically with sorafenib to attenuate HCC development in vitro and in ***:Our findings provide novel insights into choline-mediated autophagy in HCC,providing the foothold for its future application in HCC treatment.

关键词： Hepatocellular carcinoma(HCC) autophagy choline solute carrier family 5 member 7(SLC5A7)

Preparation, optimization and in vitro–in vivo investigation for capsules of the choline salt of febuxostat

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Asian Journal of Pharmaceutical Sciences 2016年第6期11卷 715-721页

作者： Xuemei Han Wanpeng Qi Wenxiang Dong Mengran Guo Panqin Ma Jing Wang School of Pharmacy Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China Kangya of Ningxia Pharmaceuticals Co.Ltd No.57FuanWest LaneYinchuan 750002China

The objective of the present study was to exhibit the enhanced water-solubility and in vivo oral absorption when febuxostat(FXT) became the salt formation of choline. The formation of the choline salt of febuxostat was confirmed by X-ray powder diffraction, infrared spectroscopy analysis and differential scanning calorimetry. The direct filling method was used to develop a capsule formulation. Cellactose 80 was used as the filler due to its good fluidity, while cross-linked polyvinylpyrrolidone(PVPP) and magnesium stearate(MS) were used as the disintegrant and lubricant, respectively. Then the in vitro release of the formulation was carried out in five different dissolution media including HCl solution(pH 1.2),acetate buffer(pH 4.5), phosphate buffer(pH 6.8 and pH 7.2) and water. Evident improvement of release for choline febuxostat(CXT) was presented in water while the dissolution degree was decreased for CXT in the medium of phosphate buffer(pH 6.8) in comparison with FXT. Furthermore, the pharmacokinetics of CXT was studied in rats using UPLC-MS/MS compared with FXT. The data acquired illustrated that AUC0-24 h of CXT and FXT were22,245.96 ± 7342.92 μg·h/l and 12,249.70 ± 2024.04 μg·h/l, respectively. The relative bioavailability of CXT to FXT was about 181.6% and the P value of AUC0-24 h was less than 0.05. It showed significant difference between the two drugs after oral administration. In conclusion, the water-solubility and oral bioavailability were both improved remarkably for the choline salt of febuxostat and choline salinization was proved an effective way to increase the in vivo absorption for FXT.

关键词： choline febuxostat Characterization Preparation In vitro release Bioavailability

Preparation and Characterization of Novel choline and L-Glutamic Acid Mixed Monolayer Covalently Modified Glassy Carbon Electrode and Its Analytical Application to Nitrite Determination

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Chinese Journal of Chemistry 2005年第6期23卷 673-677页

作者：晋冠平林祥钦 DepartmentofChemistry UniversityofScienceandTechnologyofChinaHefeiAnhui230026China

A choline and L-glutamic acid mixed monolayer covalently modified glassy carbon electrode (Ch-Glu/GCE) was fabricated and characterized by X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). It provided an excellent example of mixed covalent monolayer modification of carbon electrodes with alkanol and amino acid, and also a facile means for altering the interfacial architecture. The Ch-Glu/GCE displayed good catalytic activity toward the oxidation of nitrite anions. Differential pulse voltammetry was used for determination of nitrite at the Ch-Glu/GCE. The Ch-Glu/GCE showed higher capability for restraint of pollutions than a simple Ch modified electrode or a simple Glu modified electrode.

关键词： monolayer mixed covalently modified electrode choline L-glutamic acid nitrite

3.0 T proton magnetic resonance spectroscopy of the liver: Quantification of choline

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World Journal of Gastroenterology 2013年第9期19卷 1472-1477页

作者： Li Xu Bo Liu Yan Huang Xian Liu Si-Wei Zhang Xue-Gang Xin Ji-Zhi Zheng Department of Radiology Guangdong Provincial Traditional Chinese Medicine Hospital Postdoctoral Mobile Research Station of Guangzhou University of Traditional Chinese Medicine Department of Neurology Guangdong Provincial Traditional Chinese Medicine Hospita School of Biomedical Engineering Southern Medical University

AIM: To investigate the normal hepatic magnetic resonance spectroscopy findings choline/lipid2 (Cho/Lip2) associated with age and body mass index (BMI).METHODS: A total of 58 single-voxel proton spectra of the liver were acquired at 3.0 T using the eightchannel phased array abdominal coil as the receiver coil. Consecutive stacks of breath-hold spectra were acquired using the point resolved spectroscopy technique at a short echo time of 30 ms and a repetition time of 1500 ms. The spectra were processed with the SAGE software package. Areas and heights for metabolite resonance were obtained. Student's t test for unpaired data was used for comparisons of shimming, Cho/Lip2, and lipid content. RESULTS: There were significant negative correlations between the Cho/Lip2 peak height ratios and BMI (r=-0.615) and age (r=-0.398) (all Pcholine peak group, the high-choline peak group had lower lipid content (0.005±0.002 vs 0.13±0.23, t=-3.796,Pcholine.

关键词： Magnetic resonance spectroscopy Highfield imaging choline