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Synthesis, Characterization and Remedial Action of Biogenic Silver Nanoparticles and chitosan-Silver Nanoparticles against Bacterial Pathogens

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Journal of Renewable Materials 2022年第12期10卷 3093-3105页

作者： Piyush Kumar Gupta D.Karthik Kumar M.Thaveena Soumya Pandit Somya Sinha R.Ranjithkumar Walaa F.Alsanie Vijay Kumar Thakur Department of Life Sciences School of Basic Sciences and ResearchSharda UniversityGreater Noida201310Uttar PradeshIndia Viyen Biotech LLP CoimbatoreTamil Nadu641031India Department of Biotechnology Kongunadu Arts and Science CollegeCoimbatoreTamil Nadu641029India Department of Biotechnology Graphic Era Deemed to be UniversityDehradunUttarakhand248002India Department of Clinical Laboratories Sciences The Faculty of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biorefining and Advanced Materials Research Center SRUCEdinburghEH93JGUK Department of Mechanical Engineering School of EngineeringShiv Nadar UniversityNoidaGreater Noida201314India School of Engineering University of Petroleum&Energy Studies(UPES)DehradunUttarakhand248007India

Custard apple is a dry land fruit.Its leaves exhibit different pharmacological activities.In the present study,both silver(Ag)nanoparticles and chitosan-coated Ag(Chi-Ag)nanoparticles were fabricated using the aqueous leaf extract of the custard apple plant.During preliminary phytochemical analysis,various types of phytocompounds were found in the aqueous leaf extract of the same plant.Next,both nanoparticles were physiochemically characterized.FTIR analysis exhibited the fingerprint vibrational peaks of active bioactive compounds in plant extract,Ag nanoparticles,and Chi-Ag nanoparticles.UV/Visible spectral analysis revealed the highest absorbance peak at 419 nm,indicating the presence of Ag nanoparticles.XRD analysis presented the face-centered cubic(FCC)structure of both prepared nanomaterials.Further,the average crystalline size of both Ag nanoparticles and Chi-Ag nanoparticles was calculated to be 23 and 74 nm,respectively.FESEM analysis showed the spherical and cubical shapes of Ag nanoparticles and Chi-Ag nanoparticles,respectively.EDS analysis indicated a peak around 3.29 keV,conforming to the binding energies of Ag ions.The biogenic nanomaterial also showed strong antibacterial activity against all tested bacterial pathogens.

关键词： Custard apple chitosan Ag nanoparticles Chi-Ag nanoparticles antibacterial

Electroactive chitosan-aniline pentamer hydrogel for peripheral nerve regeneration

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Frontiers of Materials Science 2022年第3期16卷 159-169页

作者： Deqiang MIAO Ya Li Zhongbing HUANG Yulin WANG Min DENG Xiaohui LI College of Biomedical Engineering Sichuan UniversityChengdu 610065China

Electroactive hydrogels could guide the regeneration of nerves and promote their functional recovery.An aniline pentamer-crosslinked chitosan(CS-AP)hydrogel with better electroactivity and degradation was fabricated by the carbodiimide method,and then injected into the repair site of sciatic nerve damage,with its gelation time,tensile strength,and conductivity reaching 35 min,5.02-6.69 MPa,and from 2.97×10^(-4) to 3.25×10^(-4) S-cm^(-1),respectively,due to the cross-linkage and well-distribution of AP.There was better cytocompativility of CS-AP hydrogel on nerve cells.The results of the in vivo repair indicated that CS-AP10 hydrogel induced the capillaries formation and the repair of sciatic nerve defect,and re-innervated gastrocnemius muscle in the CS-AP10 group were obviously better than other experimental groups,due to the electroactivity of CS-AP and its degradation into fragments.These results indicated the potential application of CS-AP hydrogel in the regeneration and function recovery of peripheral nerve injury.

关键词： peripheral nerve regeneration chitosan aniline pentamer electroactive hydrogel capillary formation

Organic Electrochemical Transistor based on Polypyrrole/ Crosslinked chitosan/Nylon Fibers

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Journal of Wuhan University of Technology(Materials Science) 2022年第6期37卷 1080-1086页

作者：朱如枫 WANG Yao TAO Yang CHEN Yuanli 王跃丹 Key Laboratory of Textile Fiber and Products(Ministry of Education) Wuhan Textile UniversityWuhan 430200China

Glutaraldehyde(GA)crosslinked chitosan(CHIT)was modified on nylon fibers.Afterwards,pyrrole was in-situ polymerized on the surface of the CHIT/Nylon fiber.The SEM and FT-IR results show that the functional fiber is successfully prepared,and the obtained polypyrrole(PPy)presents nanorods morphology on the fiber surface.The mechanical properties of the fibers were studied by Instron.The organic electrochemical transistors based on PPy/Nylon fiber,PPy/CHIT/Nylon fiber,and PPy/GA-CHIT/Nylon fiber as channels were prepared and their transistors performance was compared.It is found that PPy/GA-CHIT/Nylon fiber-based transistor has great output,transfer,transient curves,and excellent transconductance of 6.8 mS,providing a new platform for the field of wearable devices.Furthermore,the study introduces chitosan material with excellent biocompatibility,which makes prepared transistors also have potential applications in the field of biosensing.

关键词： organic electrochemical transistors chitosan polypyrrole fiber wearable

Extraction and Characterization of Litopenaeus vannamei’s Shell as Potential Sources of chitosan Biopolymers

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Journal of Renewable Materials 2023年第3期11卷 1181-1197页

作者： Che Engku Noramalina Che Engku Chik Amyra Suryatie Kamaruzzan Ahmad Ideris Abdul Rahim Fathurrahman Lananan Azizah Endut Siti Aslamyah Nor Azman Kasan Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti MalaysiaTerengganuMalaysia East Coast Environmental Research Institute(ESERI) Universiti Sultan Zainal Abidin(UniSZA)Terengganu Darul ImanMalaysia Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin(UniSZA)Terengganu Darul ImanMalaysia Faculty of Innovative Design and Technology Universiti Sultan Zainal AbidinTerengganu Darul ImanMalaysia Faculty of Marine Science and Fisheries Hasanuddin UniversityMakassarIndonesia

Chitin is the second most abundant polysaccharide,produced mainly as an industrial waste stream during crustacean processing.Chitin can be derived into chitosan through the deacetylation process.Conversion of shrimp waste into chitosan via the deacetylation process could be considered a practical approach for shell waste remediation.In this study,chitosan’s physicochemical characteristics extracted from two types of Pacific white leg shrimp,L.vannamei’s shell(i.e.,rough and smooth),were compared with commercial chitosan.The yield,moisture,ash,solubility,water and fat binding capacity were measured.The degree of deacetylation(DDA)was calculated using FTIR,and their chemical Structure was confirmed using XRD and SEM-EDS.Both extracted chitosan showed no significant difference in yield,moisture,ash,solubility and water binding capacity but showed a significant difference with commercial chitosan.Moreover,the fat binding capacity of commercial chitosan showed the lowest percentage(408.34±0.83%)as compared to extracted chitosan(smooth shell 549.59±12.48%;rough shell 500.55±12.10%).The DDA indicated that extracted chitosan from the smooth and rough shell was considered good chitosan as compared to commercial chitosan with 84.08±1.27%,80.78±0.79%and 74.99±1.48%,respectively.Additionally,the presence of hydroxyl and amino groups from FTIR and a good crystallinity index was recorded using XRD of extracted chitosan.Based on observed characteristics,shrimp shell waste from L.vannamei can achieve chitosan standard quality as a biopolymer and highly potential to be applied in various industrial applications.

关键词： Chitin chitosan degree of deacetylation L.vannamei shrimp shell surface morphology

Modelling the mechanism and kinetics of ascorbic acid diffusion in genipin-crosslinked gelatin and chitosan networks at distinct pH

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Food Bioscience 2022年第2期46卷 684-694页

作者： Felicity A.Whitehead Stefan Kasapis School of Science RMIT UniversityMelbourneVictoria3083Australia

Crosslinked biopolymers were prepared for controlled release to investigate the diffusion of ascorbic acid from swelling high-solid networks in neutral and acidic pH conditions.Polymer swelling was measured at pH 2.8 and pH 6.8 and change in microstructural properties,including network mesh size and average molecular weight between crosslinks of genipin-crosslinked gelatin and genipin-crosslinked chitosan systems,were predicted.Variable mathematical modelling was applied to the first 60%of ascorbic acid diffusion and statistical analysis was used to determine the model that best fits the experimental data.Molecular transport from the gelatin-based networks was best described by the Peppas-Sahlin model whereas the distinct effect of pH on chitosan structure formation brought into consideration the zero-order model.Mathematical modelling of bioactive compound release from swelling biopolymer matrices at different pH conditions is essential for the design of efficient targeted delivery matrices for functional food and nutraceutical applications.

关键词： Gelatin chitosan Genipin crosslinking Ascorbic acid Diffusion kinetics

Impact of chitosan-based nanocarriers on cytoskeleton dynamics:Current status and challenges

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BIOCELL 2022年第4期46卷 885-891页

作者： M.CAROLINA DI SANTO AGUSTINA ALAIMO ANA PAULA DOMÍNGUEZ RUBIO OSCAR E.PÉREZ Departamento de Química Biológica Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales Consejo Nacional de Investigaciones Científicas y Técnicas(IQUIBICENCONICET)Buenos AiresArgentina

chitosan-based nanocarriers(CS-NCs)show a promising role in improving drugs and bioactive compounds delivery for therapy.However,the effects exerted by CS-NCs at the cellular level,including their recognition and uptake,have not been fully investigated yet.Many factors,including size,shape,concentration,and surface chemistry of CS-NCs,play an important role in determining the types of intracellular signals triggered.The mechanism of uptake and the involvement of the cytoskeleton during the CS-NCs endocytosis variates among the different cell types as well as further effects observed inside cells.In the present work,we discuss the effects induced by CS-NCs per se on the cytoskeleton,a key component in cell architecture and physiology.The focus of this report is made on tumoral and normal biological models in which CS-NCs could differentially affect the cell cytoskeleton.The recent years reports regarding the impact of CS-NCs on cytoskeleton dynamics and the current techniques for its evaluation are summarized and discussed.Understanding mechanisms underlying cytoskeletal impact after cell exposure to CS-NCs is critical for the design of safest value-added formulations in the biomedical field.Furthermore,this revision points out some interesting aspects of cytoskeletal changes and cell death encompassing anti-tumoral effects.

关键词： Cytoskeletal dynamics Cellular uptake Endocytosis Nanocarriers chitosan Bioactive compounds

A comparative study of adsorption behavior of rifampicin,streptomycin,and ibuprofen contaminants from aqueous solutions onto chitosan:Dynamic interactions,kinetics,diffusions,and mechanisms

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Emerging Contaminants 2023年第1期9卷 20-32页

作者： Ensan Waatriah E.S.Shahrin Nur Alimatul Hakimah Narudin Nurulizzatul Ningsheh MShahri Muhammad Nur Jun-Wei Lim Muhammad Roil Bilad Abdul Hanif Mahadi Jonathan Hobley Anwar Usman Department of Chemistry Faculty of ScienceUniversiti Brunei DarussalamJalan Tungku LinkGadongBE1410Brunei Darussalam Center for Plasma Research Integrated LaboratoryUniversitas DiponegoroTembalangSemarang50275Indonesia HICoE-Centre for Biofuel and Biochemical Research Institute of Self-Sustainable BuildingDepartment of Fundamental and Applied SciencesUniversiti Teknologi PETRONAS32610Seri IskandarPerak Darul RidzuanMalaysia Faculty of Integrated Technologies Jalan Tungku LinkGadongBE1410Brunei Darussalam Centre for Advanced Material and Energy Sciences Universiti Brunei DarussalamJalan Tungku LinkGadongBE1410Brunei Darussalam Department of Biomedical Engineering National Cheng Kung UniversityNo.1 University RoadTainan City 701Taiwan

Adsorptive removal and dynamic interaction of three different pharmaceutical pollutants,namely rifampicin(RIF),streptomycin(STM),and ibuprofen(IBU)onto chitosan were systematically investigated using a batch adsorption technique at different processing parameters.In this study,chitosan was derived from mud-crab shells,as an innovative way to use the waste from marine foods as adsorbents.The kinetics,intraparticle diffusion,mechanism,and thermodynamics of the adsorption were systematically evaluated and analyzed using kinetic models,Boyd mass transfer and WebereMorris intraparticle diffusion models,Langmuir,Freundlich,DubinineRadushkevich,and Temkin isotherm models,and the Gibbs equation.The adsorption isotherm of the larger molecules,RIF and STM,could be explained by the Langmuir isotherm model,in contrast,that of IBU,which is a much smaller molecule,followed the Freundlich isotherm model.The maximum adsorption capacity of RIF,STM,and IBU on chitosan was estimated to be 66.91 mg g^(-1),11.00 mg g^(-1),and 24.21 mg g^(-1),respectively,which are higher compared to those on a variety of agricultural wastes,suggesting that this biopolymer is a potential practical and economical adsorbent to remove the pharmaceutical compounds from wastewater.The adsorption mechanism of the pharmaceutical compounds on chitosan is proposed based on the vibrational spectroscopic analyses,XRD patterns,and DSC thermograms of the biopolymer before and after adsorption process.

关键词： Adsorption Rifampicin Streptomycin Ibuprofen chitosan Mud-carb shells

Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： Chang-Soo Han Ji-Hyun Kang Eun hye Park Hyo-Jung Lee So-Jeong Jeong Dong-Wook Kim Chun-Woong Park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying method.The amount and the boiling point of the organic acid affected the degree of roughness.In this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder inhaler.HMP175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid solution.The ACI and PIV results showed a significant increase in aerodynamic performance of corrugated microparticles.The FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 L20.Corrugated microparticles also showed better aerosolization,decreased x-axial velocity,and variable angle.Rapid dissolution of drug formulationswas observed in vivo.Lowdoses administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered orally.Surface modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance

The effect of nano-calcium carbonate onβ-glucosidase immobilized by alginate and chitosan

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2022年第3期3卷 265-271页

作者： Mariam Iqbal Yuefeng Deng Qiaoyue Chen Chengli Yang Yihui Zhu Ziqian Chen Jianjun Wang Kaishun Hu Guanya He Dali Li Department of Bioengineering School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Nanotechnology has become the most promising domain to boost the efficiency of enzymes.Enzymes are vital as a green catalyst in many industries,food,pharmaceutical and biomedical,etc.The immobilization process of the enzyme increases its catalytic properties.In this research,a novel method is presented to describe the effect of nano-calcium carbonate on the characteristics of immobilizedβ-glucosidase,which was extracted from the Agrocybe aegirit.The nano-CaCO_(3)was produced using the eco-friendly natural deep eutectic solvent.The pure nano-CaCO_(3)was observed as vaterite,with a size of about 300 nm.The nano-calcium carbonate was coated by a natural polymer sodium alginate compound and then adsorbed chitosan.Further,this obtained composite is cross-linked by the bioactive genipin to immobilize theβ-glucosidase.The enzyme/protein loading ratio to the supports was 1:4,respectively.The recovery efficiency of immobilizedβ-glucosidase was 89.3%,and immobilization yield was 96.452%.chitosan-coated nano-CaCO_(3)was used as a carrier for immobilization ofβ-glucosidase to improve its stability and reusability.In addition to stability and reusability,pH tolerance,temperature tolerance,and enzyme kinetics are the significant parameters that illustrate the proficiency of an immobilized enzyme.The measured optimal enzymatic reaction conditions for the immobilizedβ-glucosidase were 50℃and pH 6.Furthermore,it has shown noticeable improvements in thermo-stability and pH tolerance.Temperature tolerance was observed 50%to the initial activity of the immobilized enzyme even after the 3 h of incubation at 50℃,while pH tolerance was noticed more than 50%and 40%at pH 7 and 8,respectively.The K_(m)and V_(max)values of free and immobilizedβ-glucosidase to 4-nitrophenylβ-D-glucopyranoside were 1.549μmol/L/min,0.346 mmol/L and 0.532μmol/L/min,0.080 mmol/L,respectively.The immobilizedβ-glucosidase retains its storability 80%even after 30 days of storage at 4℃and maintains 93.1%of its residual activity by reusing up to 10 cycles.

关键词： Immobilization Nano-CaCO_(3) Sodium alginate chitosan Genipin