检索结果-南通市图书馆

Kinetic characterization of a slow chemical exchange between two sites in N,N-dimethylacetylamide by CEST NMR spectroscopy

引用

Chinese chemical Letters 2022年第9期33卷 4335-4338页

作者： Lixia Wang Jikun Li Junfeng Xiang Jie Cui Yalin Tang Beijing National Laboratory for Molecular Sciences(BNLMS) Center for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Nuclear magnetic resonance(NMR)spectroscopy has provided many powerful tools for the study of dynamic *** the reported methods,chemical exchange saturation transfer(CEST)is more suitable for systems with slow exchange rates,and there will be promising in the detection and dynamic mechanism of metastable *** has been widely used in magnetic resonance imaging(MRI),however whether it is applicable in the field of chemical kinetics needs more *** we studied,as a proof of concept,the kinetics of the slow chemical exchange between the two N-methyl protons of N,N-dimethylacetylamide(DMA),exploiting QUantifying exchange using Z-spectrum(QUEZS)and QUantifying exchange using Saturation Time(QUEST)*** turned out that both of QUEZS and QUEST could give the corresponding exchange rates,showcasing the capability of this method to provide accurate kinetic data under a range of *** results clearly demonstrated the reliability of CEST-based techniques as a tool for dynamic kinetics by NMR.

关键词： chemical exchange saturation transfer(CEST) chemical exchange N,N-Dimethylacetylamid Bloch-Mc Connell equation Dynamic kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detecting water-protein chemical exchange in membrane- bound proteins/peptides by solid-state NMR spectroscopy--Dedicated to Professor Xiuwen Han on the occasion of her 80th birthday

引用

Magnetic Resonance Letters 2021年第2期1卷 99-111页

作者： Rongfu Zhang Timothy A.Cross Riqiang Fu National High Magnetic Field Laboratory 1800 East Paul Dirac DriveTallahasseeFL32310USA Department of Chemistry and Biochemistry Florida State UniversityTallahasseeFL32301USA

Water plays an important role in many essential biological processes of membrane proteins in hydrated lipid *** general,the 1H polarization transfers berween water molecules and site--specific protons in proteins can be classified as coherent(via dipolar spin diffusion)and incoherent(via chemical exchange and nuclear Overhauser effect)***-state NMR is the technique of choice for studying such water-protein interactions in membrane-bound proteins/peptides through the detection of'H polarization transfers from water to the *** polarization transfer mechanisms often exist simultaneously and are difficult to quantify ***,we review water-protein polarization transfer techniques in solid state NMR with a focus on the recent progress for the direct detection of site-specific kinetic water-protein chemical exchange processes on the sub-millisecond time scale in membrane-bound *** measurements of the pure chemical exchange ki-netics provide a unique opportunity to understand the role that water plays in the structure-function relationships of membrane bound species at the water-bilayer *** addi-tion,the perspective of chemical exchange saturation transfer(CEST)experiments in membrane-bound proteins/peptides is further discussed.

关键词： chemical exchange Spin diffusion HETCOR CEST Water-protein interactions Solid-state NMR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Label-Free chemically and Molecularly Selective Magnetic Resonance Imaging

引用

chemical & Biomedical Imaging 2023年第2期1卷 121-139页

作者： Tianhe Wu Claire Liu Anbu Mozhi Thamizhchelvan Candace Fleischer Xingui Peng Guanshu Liu Hui Mao Department of Radiology and Imaging Sciences Emory University School of MedicineAtlantaGeorgia 30322United States F.M.Kirby Research Center for Functional Brain Imaging Kennedy Krieger InstituteBaltimoreMaryland 21205United States Jiangsu Key Laboratory of Molecular and Functional Imaging Department of RadiologyZhongda HospitalMedical School of Southeast UniversityNanjingJiangsu 210009China Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of MedicineBaltimoreMaryland 21205United States

Biomedical imaging,especially molecular imaging,has been a driving force in scientific discovery,technological innovation,and precision medicine in the past two *** substantial advances and discoveries in chemical biology have been made to develop molecular imaging probes and tracers,translating these exogenous agents to clinical application in precision medicine is a major *** the clinically accepted imaging modalities,magnetic resonance imaging(MRI)and magnetic resonance spectroscopy(MRS)exemplify the most effective and robust biomedical imaging *** MRI and MRS enable a broad range of chemical,biological diagnosis and characterization of many diseases and image-guided *** chemical,biological,and nuclear magnetic resonance properties of specific endogenous metabolites and native MRI contrast-enhancing biomolecules,label-free molecular and cellular imaging with MRI can be achieved in biomedical research and clinical management of patients with various *** review article outlines the chemical and biological bases of several label-free chemically and molecularly selective MRI and MRS methods that have been applied in imaging biomarker discovery,preclinical investigation,and image-guided clinical *** are provided to demonstrate strategies for using endogenous probes to report the molecular,metabolic,physiological,and functional events and processes in living systems,including *** perspectives on label-free molecular MRI and its challenges as well as potential solutions,including the use of rational design and engineered approaches to develop chemical and biological imaging probes to facilitate or combine with label-free molecular MRI,are discussed.

关键词： Magnetic resonance imaging Magnetic resonance spectroscopy Molecular imaging Label-free Metabolic imaging chemical exchange Diffusion Perfusion Imaging probe

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：