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Drug adulteration analysis based on complexation with cyclodextrin and metal ions using ion mobility spectrometry

Journal of Pharmaceutical Analysis 2023年第3期13卷 287-295页

作者： Zhigang Liang Huanhuan Wang Fangling Wu Longfei Wang Chenwei Li Chuan-Fan Ding Department of Thoracic Surgery Ningbo First HospitalNingbo UniversityNingboZhejiang315010China Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province Institute of Mass SpectrometrySchool of Material Science and Chemical EngineeringNingbo UniversityNingboZhejiang315211China

Drug adulteration and contamination are serious threats to human health therefore,their accurate monitoring is very ***(Alp)and theophylline(Thp)are commonly used drugs for the treatment of gout and bronchitis,while their isomers hypoxanthine(Hyt)and theobromine(Thm)have no effect and affect the efficacy of the *** this work,the drug isomers of Alp/Hyt and Thp/Thm are simply mixed withα-,β-,γ-cyclodextrin(CD)and metal ions and separated using trapped ion mobility spectrometry-mass spectrometry(TIMS-MS).TIMS-MS results showed that Alp/Hyt and Thp/Thm isomers could interact with CD and metal ions and form corresponding binary or ternary complexes to achieve their TIMS *** metal ions and CDs showed different separation effect for the isomers,among which Alp and Hyt could be successfully distinguished from the complexes of[Alp/Hyt+γ-CD+Cu–H]^(+)with separation resolution(RP–P)of 1.51;whereas Thp and Thm could be baseline separated by[Thp/Thm+γ-CD+Ca–H]^(+)with RP–P of ***,chemical calculations revealed that the complexes were in the inclusion forms,and microscopic interactions were somewhat different,making their mobility ***,relative and absolute quantification was investigated with an internal standard to determine the precise isomers content,and good linearity(R^(2)>0.99)was ***,the method was applied for the adulteration detection where different drugs and urine were *** addition,due to the advantages of fast speed,simple operation,high sensitivity,and no chromatographic separation required,the proposed method provides an effective strategy for the drug adulteration detection of isomers.

关键词： Drug isomer Adulteration Separation Ion mobility chemical calculations

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