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cellular models for disease exploring and drug screening

Protein & Cell 2010年第4期1卷 355-362页

作者： Zhi-kun Li Qi Zhou State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate School Chinese Academy of SciencesBeijing 100049China

The biopharmaceutical industry has been greatly promoted by the application of drug and disease models,including both animal and cellular *** particular,the emergence of induced pluripotent stem cells(iPSC)makes it possible to create a large number of diseasespecific cells in *** review introduces the most widely applied models and their specialties.

关键词： cellular models disease models induced pluripotential stem cells neural diseases

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Modernising autism spectrum disorder model engineering and treatment via CRISPR-Cas9:A gene reprogramming approach

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World Journal of Clinical Cases 2023年第14期11卷 3114-3127页

作者： Arushi Sandhu Anil Kumar Kajal Rawat Vipasha Gautam Antika Sharma Lekha Saha Department of Pharmacology Post Graduate Institute of Medical Education and Research(PGIMER)Chandigarh 0172ChandigarhIndia

A neurological abnormality called autism spectrum disorder(ASD)affects how a person perceives and interacts with others,leading to social interaction and communication *** and recurring behavioural patterns are another feature of the *** mutations throughout development are the source of the neurodevelopmental disorder ***,a well-established model and perfect treatment for this spectrum disease has not been *** rising era of the clustered regularly interspaced palindromic repeats(CRISPR)-associated protein 9(Cas9)system can streamline the complexity underlying the pathogenesis of *** CRISPR-Cas9 system is a powerful genetic engineering tool used to edit the genome at the targeted site in a precise *** major hurdle in studying ASD is the lack of appropriate animal models presenting the complex symptoms of ***,CRISPR-Cas9 is being used worldwide to mimic the ASD-like pathology in various systems like in vitro cell lines,in vitro 3D organoid models and in vivo animal *** from being used in establishing ASD models,CRISPR-Cas9 can also be used to treat the complexities of *** aim of this review was to summarize and critically analyse the CRISPRCas9-mediated discoveries in the field of ASD.

关键词： Autism spectrum disorder CRISPR-Cas9 cellular models Organoids Animal models Therapeutic strategies

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