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cellular & Molecular Immunology 2009年第2期6卷 111-116页

作者： Shafi Mojadadi Abbas Jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad Neuroscience research center Kerman University of Medical Sciences Department of Virology Faculty of medical science Tarbiat Modares University Dept of virology School of medicalsciences Tarbiat Modares University Dept of Microbiology Arak University of Medical Sciences

Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte （CTL） activity in the inhibition of herpes simplex virus type 1 （HSV-1） reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-γ. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.

关键词： acute morphine herpes simplex virus-1 reactivation cell-mediated immunity

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Immune Responses to Varicella-Zoster Virus Glycoprotein E Formulated with Poly(Lactic-co-Glycolic Acid) Nanoparticles and Nucleic Acid Adjuvants in Mice

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Virologica Sinica 2021年第1期36卷 122-132页

作者： Yunfei Wang Jialong Qi Han Cao Cunbao Liu Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118China

The subunit herpes zoster vaccine Shingrix is superior to attenuated vaccine Zostavax in both safety and efficacy,yet its unlyophilizable liposome delivery system and the limited supply of naturally sourced immunological adjuvant QS-21 still need to be *** on poly(lactic-co-glycolic acid)(PLGA)delivery systems that are stable during the lyophilization and rehydration process and using a double-emulsion(w/o/w)solvent evaporation method,we designed a series of nanoparticles with varicella-zoster virus antigen glycoprotein E(VZV-g E)as an antigen and nucleic acids including polyinosinic-polycytidylic acid(Poly I:C)and phosphodiester Cp G oligodeoxynucleotide(Cp G ODN),encapsulated as immune *** cationic lipids(DOTAP)have more potential than neutral lipids(DOPC)for activating g E-specific cell-mediated immunity(CMI)in immunized mice,especially when g E is encapsulated in and presented on the surface of nanoparticles,PLGA particles without lipids have the greatest potential to induce not only the highest g Especific Ig G titers but also the strongest g E-specific CMI responses,including the highest proportions of interferon-c(IFNc)-and interleukin-2(IL-2)-producing CD4?/CD8?T cells according to a flow cytometry assay and the greatest numbers of IFN-c-and IL-2-producing splenocytes according to an enzyme-linked immunospot(ELISPOT)*** results showed that immune-stimulating nucleic acids together with the PLGA delivery system showed promise as a safe and economical varicella and zoster vaccine candidate.

关键词： Varicella-zoster virus subunit vaccine cell-mediated immunity Nucleic acid immune stimulator Poly I:C CpG ODN PLGA Nanoparticle

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A live attenuated virus-based intranasal COVID-19 vaccine provides rapid,prolonged,and broad protection against SARS-CoV-2

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Science Bulletin 2022年第13期67卷 1372-1387,M0004页

作者： unyu Chen Pui Wang Lunzhi Yuan Liang Zhang Limin Zhang Hui Zhao Congjie Chen Xijing Wang Jinle Han Yaode Chen Jizong Jia Zhen Lu Junping Hong Zicen Lu Qian Wang Rirong Chen Ruoyao Qi Jian Ma Min Zhou Huan Yu Chunlan Zhuang Xiaohui Liu Qiangyuan Han Guosong Wang Yingying Su Quan Yuan Tong Cheng Ting Wu Xiangzhong Ye Tianying Zhang Changgui Li Jun Zhang Huachen Zhu Yixin Chen Honglin Chen Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamen 361102China State Key Laboratory of Emerging Infectious Diseases School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China National Institute for Food and Drug Control Beijing 102629China Beijing Wantai Biological Pharmacy Enterprise Co. Ltd.Beijing 102206China Guangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases/Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases Joint Institute of Virology(STU/HKU)Shantou UniversityShantou 515063China EKIH Pathogen Research Institute Shenzhen 518067China

Remarkable progress has been made in developing intramuscular vaccines against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);however,they are limited with respect to eliciting local immunity in the respiratory tract,which is the primary infection site for *** overcome the limitations of intramuscular vaccines,we constructed a nasal vaccine candidate based on an influenza vector by inserting a gene encoding the receptor-binding domain(RBD)of the spike protein of SARSCoV-2,named CA4-d NS1-n CoV-RBD(d NS1-RBD).A preclinical study showed that in hamsters challenged 1d after single-dose vaccination or 9 months after booster vaccination,d NS1-RBD largely mitigated lung pathology,with no loss of body ***,such cellular immunity is relatively unimpaired for the most concerning SARS-Co V-2 variants,especially for the latest Omicron *** addition,this vaccine also provides cross-protection against H1N1 and H5N1 influenza *** protective immune mechanism of d NS1-RBD could be attributed to the innate immune response in the nasal epithelium,local RBD-specific T cell response in the lung,and RBD-specific Ig A and Ig G ***,this study demonstrates that the intranasally delivered d NS1-RBD vaccine candidate may offer an important addition to the fight against the ongoing coronavirus disease 2019 pandemic and influenza infection,compensating limitations of current intramuscular vaccines.

关键词： COVID-19 SARS-CoV-2 Intranasal vaccine Influenza vector cell-mediated immunity

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细胞介导免疫在EAE发病中的作用

中国免疫学杂志 1985年第2期 9-12页

作者：周建年杨贵贞白求恩医科大学微生物学教研室白求恩医科大学微生物学教研室长春

实验性变态反应性脑脊髓炎(简称EAE)是一种人工诱导的中枢神经系统自身免疫性疾病,也是自身免疫病的代表模式。关于EAE的免疫损伤机理,大多数学者认为致敏T细胞是引起EAE免疫损伤的主要原因;但也有报告指出:抗体也参与其损伤过程。有关... 详细信息

实验性变态反应性脑脊髓炎(简称EAE)是一种人工诱导的中枢神经系统自身免疫性疾病,也是自身免疫病的代表模式。关于EAE的免疫损伤机理,大多数学者认为致敏T细胞是引起EAE免疫损伤的主要原因;但也有报告指出:抗体也参与其损伤过程。有关这个问题的意见尚不统一。我们曾经在建立模型、提取髓磷脂硷蛋白(简称Bp)以及特异性免疫应答等方面做过一些工作。本文则以不同的实验手段和方法对EAE致病的主要原因作一系统观察,并对其可能的机理作出粗浅的分析。材料与方法一、动物及分组:豚鼠,由本校动物室供应。实验设有不同月龄组(4月龄,2 1/2月龄,1 1/2月龄)和新生期胸腺切除组,共4个组别,后者为2 1/2月龄,体重450g左右。各相应组别中,雌雄成比例分配。

关键词： Myelin Basic Protein Experimental Allergic Encephalomyelitis cell-mediated immunity

Immune Responses Against SARS-Coronavirus Nucleocapsid Protein Induced by DNA Vaccine

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Immune Responses Against SARS-Coronavirus Nucleocapsid Prote...