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Target morphology and cell memory:a model of regenerative pattern formation

Neural Regeneration Research 2015年第12期10卷 1901-1905页

作者： Nikolai Bessonov Michael Levin Nadya Morozova Natalia Reinberg Alen Tosenberger Vitaly Volpert Institute of Problems of Mechanical Engineering Russian Academy of Sciences Department of Biology Tufts Center for Regenerative & Developmental BiologyTufts University Laboratoire Epigénétique et Cancer Institut des Hautes Etudes Scientiques Unité de Chronobiologie Théorique Faculté des SciencesUniversité Libre de BruxellesCampus Plaine Institut Camille Jordan UMR 5208 CNRSUniversity Lyon 1

Despite the growing body of work on molecular components required for regenerative repair,we still lack a deep understanding of the ability of some animal species to regenerate their appropriate complex anatomical structure following damage.A key question is how regenerating systems know when to stop growth and remodeling-what mechanisms implement recognition of correct morphology that signals a stop condition？In this work,we review two conceptual models of pattern regeneration that implement a kind of pattern *** the first one,all cells communicate with each other and keep the value of the total signal received from the other *** a part of the pattern is amputated,the signal distribution *** difference fromthe original signal distribution stimulates cell proliferation and leads to pattern regeneration,in effect implementing an error minimization process that uses signaling memory to achieve pattern *** the second model,we consider a more complex pattern organization with different cell *** tissue contains a central（coordinator）cell that controls the tissue and communicates with the other central *** of them keeps memory about the signals received from other central *** values of these signals depend on the mutual cell location,and the memory allows regeneration of the structure when it is *** purpose of these models is to suggest possible mechanisms of pattern regeneration operating on the basis of cell memory which are compatible with diverse molecular implementation mechanisms within specific organisms.

关键词： target morphology pattern regeneration cell memory morphogenesis cell signaling mathematical modeling agent-based model

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The multifaceted PDCD10/CCM3 gene

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Genes & Diseases 2021年第6期8卷 798-813页

作者： Mariaelena Valentino Elisabetta Dejana Matteo Malinverno The FIRC Institute of Molecular Oncology(IFOM) Milan1620139Italy Department of Oncology and Haemato-Oncology University of MilanMilan720122Italy Vascular Biology Department of ImmunologyGenetics and PathologyUppsala UniversityUppsalaSE-75105Sweden

The programmed cell death 10(PDCD10)gene was originally identified as an apoptosis-related gene,although it is now usually known as CCM3,as the third causative gene of cerebral cavernous malformation(CCM).CCM is a neurovascular disease that is characterized by vascular malformations and is associated with headaches,seizures,focal neurological deficits,and cerebral *** PDCD10/CCM3 protein has multiple subcellular localizations and interacts with several multi-protein complexes and signaling *** PDCD10/CCM3 governs many cellular functions,which include cell-to-cell junctions and cytoskeleton organization,cell proliferation and apoptosis,and exocytosis and *** its central role in the maintenance of homeostasis of the cell,dysregulation of PDCD10/CCM3 can result in a wide range of altered cell *** can lead to severe diseases,including CCM,cognitive disability,and several types of ***,we review the multifaceted roles of PDCD10/CCM3 in physiology and pathology,with a focus on its functions beyond CCM.

关键词： Cancer cell signaling cell-cycle Neurovascular unit PDCD10/CCM3

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Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis

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World Journal of Gastroenterology 2014年第41期20卷 15190-15199页

作者： Enrico Lupia Luca Pigozzi Alberto Goffi Emilio Hirsch Giuseppe Montrucchio Department of Medical Sciences University of Torino Emergency Medicine Unit "Città della Salute e della Scienza" Hospital Interdepartmental Division of Critical Care Medicine University of Toronto Molecular Biotechnology Center Department of Molecular Biotechnology and Health SciencesUniversity of Torino

A large body of experimental and clinical data supports the notion that inflammation in acute pancreatitis has a crucial role in the pathogenesis of local and systemic damage and is a major determinant of clinical severity. Thus, research has recently focused on molecules that can regulate the inflammatory processes, such as phosphoinositide 3-kinases (PI3Ks), a family of lipid and protein kinases involved in intracellular signal transduction. Studies using genetic ablation or pharmacologic inhibitors of different PI3K isoforms, in particular the class I PI3Kδ and PI3Kγ, have contributed to a greater understanding of the roles of these kinases in the modulation of inflammatory and immune responses. Recent data suggest that PI3Ks are also involved in the pathogenesis of acute pancreatitis. Activation of the PI3K signaling pathway, and in particular of the class IB PI3Kγ isoform, has a significant role in those events which are necessary for the initiation of acute pancreatic injury, namely calcium signaling alteration, trypsinogen activation, and nuclear factor-κB transcription. Moreover, PI3Kγ is instrumental in modulating acinar cell apoptosis, and regulating local neutrophil infiltration and systemic inflammatory responses during the course of experimental acute pancreatitis. The availability of PI3K inhibitors selective for specific isoforms may provide new valuable therapeutic strategies to improve the clinical course of this disease. This article presents a brief summary of PI3K structure and function, and highlights recent advances that implicate PI3Ks in the pathogenesis of acute pancreatitis.

关键词： Phosphoinositide 3-kinase cell signaling Inflammation Pathogenesis Acute pancreatitis

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Anti-nutritional characteristics and mechanism of soybean agglutinin

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BIOcell 2021年第3期45卷 451-459页

作者： LI PAN JIAWEI LIU MOHAMMED HAMDY FAROUK GUIXIN QIN NAN BAO YUAN ZHAO HUI SUN Key Laboratory of Animal Production Product Quality and SecurityMinistry of EducationKey Laboratory of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyJilin Agricultural UniversityChangchun130118China Animal Production Department Faculty of AgricultureAl-Azhar UniversityCairo11884Egypt

Soybean agglutinin(SBA)is an important anti-nutritional factor in *** can induce animal growth inhibition,cause pathological changes of intestinal tissue,and decrease in the immune system ***,a great deal of research has been done on the effects of SBA on cell morphology,division,apoptosis,autophagy,as well as the correlated signal transduction *** review mainly covers the chemical and biological characteristics of SBA,describes the multifaceted aspects of SBA anti-nutritional functions,and highlights the possible cellular and molecular mechanism of anti-nutritional effects of *** review has important implications for the prevention and treatment of SBA-induced diseases,drug development,processing techniques of plant products,prevention of food-borne toxins,as well as human and animal health protection.

关键词： Soybean agglutinin Autophagy cell apoptosis Anti-nutritional functions cell signaling

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Biocompatibility pathways and mechanisms for bioactive materials:The bioactivity zone

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Bioactive Materials 2022年第4期7卷 306-322页

作者： David F.Williams Wake Forest Institute of Regenerative Medicine 391 Technology Way.Winston-SalemNorth Carolina27101USA

This essay analyzes the scientific evidence that forms the basis of bioactive materials,covering the fundamental understanding of bioactivity phenomena and correlation with the mechanisms of biocompatibility of *** is a detailed assessment of performance in areas such as bone-induction,cell adhesion,immunomodulation,thrombogenicity and antimicrobial *** is the modulation of biological activity by characteristics of the interfacial region that incorporates the material surface and the immediate local host *** the term‘bioactive material’is widely used and has a well understood general meaning,it would be useful now to concentrate on this interfacial region,considered as‘the bioactivity zone’.Bioactivity phenomena are either due to topographical/micromechanical characteristics,or to biologically active species that are presented in the bioactivity *** of topographical/micromechanical effects are the modulation of the osteoblast-osteoclast balance,nanotopographical regulation of cell adhesion,and bactericidal *** of bioactivity by biologically active species include their influence,especially of metal ions,on signaling pathways in bone formation,the role of cell adhesion molecules and bioactive peptides in cell attachment,macrophage polarization by immunoregulatory molecules and antimicrobial *** much experimental data exists to demonstrate the potential of such phenomena,there are considerable barriers to their effective clinical *** essay shows that there is solid scientific evidence of the existence of bioactivity mechanisms that are associated with some types of biomaterials,especially when the material is modified in a manner designed to specifically induce that activity.

关键词： Bioactivity Host response Biomaterial Medical technology cell signaling

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Antagomir Dependent MicroRNA-205 Reduction Enhances Adhesion Ability of Human Corneal Epithelial Keratinocytes

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Chinese Medical Sciences Journal 2010年第2期25卷 65-70页

作者： Jun Li Hua Bai Yong Zhu Xiao-yan Wang Fang Wang Jun-wu Zhang Robert M. Lavker Jia Yu Department of Biochemistry Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100005 China Department of Cardiology Chongqing First-aid Medical Center Chongqing 400014 China Department of Ophthalmology The Military General Hospital of Beijing PLA Beijing 100700 China Department of Dermatology Feinberg School of Medicine Northwestern University Chicago 60611 USA

Objective To investigate the effect of microRNA-205 reduction by antagomirs on adhesion ability of normal human corneal epithelial keratinocytes(NHCEKs).Methods Antagomir-205,complementary and inhibitory to microRNA-205,was used to suppress endogenous microRNA-205 in *** adhesion ability of treated NHCEKs was then assessed by cell adhesion *** and immunohistochemistry were conducted to determine the level of two focal adhesion-related proteins,focal adhesion kinase(FAK) and paxillin(Pax).Phalloidin staining was performed to measure the level of filamentous actin in antagomir-treated *** Antagomir-205 markedly reduced the level of microRNA-205 in NHCEKs and significantly enhanced adhesion ability of NHCEKs(Pcell motility in NHCEKs.

关键词： corneal epithelium cell signaling microRNA

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Targeting secret handshakes of biological processes for novel drug development

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Frontiers in Biology 2016年第2期11卷 132-140页

作者： Rini Jacob Anbalagan Moorthy School of Bio-Sciences and Technology VIT University Vellore-632014 India

In multicellular organisms, several biological processes control the rise and fall of life. Different cell types communicate and co-operate in response to different stimulus through cell to cell signaling and regulate biologic processes in the cell/organism. signaling in multicellular organism has to be made very secretly so that only the target cell responds to the signal. Of all the biomolecules, nature chose mainly proteins for secret delivery of information both inside and outside the cell. During cell signaling, proteins physically interact and shake hands for transfer of secret information by a phenomenon called as protein protein interactions （PPIs）. In both, extra and intracellular signaling processes PPIs play a crucial role. PPIs involved in cellular signaling are the primary cause for cell proliferation, differentiation, movement, metabolism, death and various other biological processes not mentioned here. These secret handshakes are very specific for specific functions. Any alterations/malfunctions in particular PPIs results in diseased condition. An overview of signaling pathways and importance of PPIs in cellular function and possibilities of targeting PPIs for novel drug development are discussed in this review.

关键词： cell signaling protein-protein interactions peptide inhibitors

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Crosstalk of the Wnt/b-catenin pathway with other pathways in cancer cells

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Genes & Diseases 2016年第1期3卷 41-47页

作者： Saint-Aaron L.Morris Suyun Huang Department of Neurosurgery The University of Texas MD Anderson Cancer Center1515 Holcombe BoulevardHoustonTX 77030USA Program in Cancer Biology The University of Texas Graduate School of Biomedical Sciences6767 Bertner AvenueMitchell Building BSRB S3.8344HoustonTX 77030USA

Many cancers have similar aberrations in various signaling cascades with crucial roles in cellular proliferation,differentiation,and *** of signal cascades that play integral roles during early cellular development is well known to be a central feature of many *** such signaling cascade is the Wnt/b-catenin pathway,which has a profound effect on stem cell proliferation,migration,and *** pathway is dysregulated in numerous cell types,underscoring its global oncogenetic *** review highlights regulators and downstream effectors of this receptor cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling *** understanding of the genetic and epigenetic changes unique to these malignancies increases,identifying the regulatory mechanisms unique to the Wnt/b-catenin pathway and similarly aberrant receptor pathways will be imperative.

关键词： b-catenin cell signaling Glioma stem cell Tumorigenicity Wnt

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Effects of nitric oxide on reproductive organs and related physiological processes

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Asian pacific Journal of Reproduction 2020年第4期9卷 159-165页

作者： Ayoob Rostamzadeh Reza Ahmadi Mahdi Heydari Amir Raoofi Student Research Committee Department of Anatomical SciencesFaculty of MedicineIran University of Medical SciencesTehranIran Clinical Biochemistry Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Leishmaniasis Research Center Department of AnatomySabzevar University of Medical SciencesSabzevarIran

Nitric oxide(NO),a member of the reactive nitrogen species family,plays a role in several physiologic processes,including vasculogenesis and angiogenesis,growth and puberty,and senescence and *** plays an important role in the production of ovarian steroids,ovulation,and follicular *** other words,increased activity of nitric oxide synthase(NOS)leads to an increased amount of NO,which triggers production of prostaglandins and inflammatory cascades which facilitate follicular rupture and *** concentration elevation inhibits steroid synthesis in luteal and granulosa *** NO is a major paracrine mediator of various biological processes,as well as a key factor in both the reproductive cycle and embryo implantation,oversynthesis of NO in the uterus results in toxicity and inflammation in epithelial cells and immunorejection of *** the male physiological system,NO synthesized by NOS plays a major role in erectile function and androgen secretion,as well as semen parameters,and oocyte junction to the ***,this supposedly simple molecule is involved in a number of other functions,such as germ cell evolution,connections between sertoli cells and germ cells in the blood-testis barrier,homodynamic contraction,and germ cell ***,NO is considered a key factor in male fertility due to its widespread distribution in both normal and diseased testis *** difference of expression level of NOS in normal and pathological states is a probable cause of fertility destructive processes.

关键词： Reproduction Nitric oxide Nitric oxide synthase cell signaling Oxidants

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Emerging role of the orphan nuclear receptor estrogen-related receptor gamma in liver metabolic diseases

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Liver Research 2019年第2期3卷 99-105页

作者： Don-Kyu Kim Hueng-Sik Choi Department of Molecular Biotechnology Chonnam National UniversityGwangjuRepublic of Korea National Creative Research Initiatives Center for Nuclear Receptor Signals Hormone Research CenterSchool of Biological Sciences and TechnologyChonnam National UniversityGwangjuRepublic of Korea

Estrogen-related receptor gamma(ERRg)is one of three members of the ERR family and remains an orphan,as there are no known natural *** is an inducible transcription factor,and its ligandindependent transcriptional activity is regulated by co-regulator interactions and post-transcriptional *** findings from animal models show that ERRg,as a downstream mediator of multiple extracellular signals,plays a key role in coordinating endocrine and metabolic signals,resulting in changes in glucose,alcohol,lipid,and iron metabolism in the ***,dysregulation of this receptor contributes to the pathogenesis of metabolic diseases such as hyperglycemia,insulin resistance,and alcoholic liver ***,ERRg is also involved in responses to bacterial *** findings establish the importance of ERRg in the endocrine and metabolic control of liver metabolism,and suggest that ERRg may be a promising therapeutic target for metabolic diseases of the liver.

关键词： Orphan nuclear receptor Estrogen-related receptor gamma(ERRg) Gene regulation cell signaling Liver metabolism

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