The multifaceted PDCD10/CCM3 gene

作     者：Mariaelena Valentino Elisabetta Dejana Matteo Malinverno 

作者机构：The FIRC Institute of Molecular Oncology(IFOM)Milan1620139Italy Department of Oncology and Haemato-OncologyUniversity of MilanMilan720122Italy Vascular BiologyDepartment of ImmunologyGenetics and PathologyUppsala UniversityUppsalaSE-75105Sweden 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2021年第8卷第6期

页      面：798-813页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 100204[医学-神经病学] 10[医学] 

基　　金：The lab of ED is supported by:The Swedish Research Council(contract No.2013-9279),the Knut and Alice Wallenberg Foundation(contract No.2015-0030),the European Research Council(project EC-ERC-VEPC,contract 74292),Associazione Italiana per la Ricerca sul Cancro(AIRC IG 23223),AIRC 5x1000 call"Metastatic disease:the key unmet need in oncology"to the MYNERVA Project(MYeloid NEoplasms Research Venture AIRC 21267),Telethon(New insight on the pathogenesis of hereditary Cerebral Cavernous Malformation,contract GGP19202) AIFA(a multicellular randomized clinical trial on propranolol in familial Cerebral Cavernous Malformation,contract AIFA-2016-02364593).Be Brave for Life Foundation Micro Grant 2019 

主　　题：Cancer Cell signaling Cell-cycle Neurovascular unit PDCD10/CCM3 

摘      要：The programmed cell death 10(PDCD10)gene was originally identified as an apoptosis-related gene,although it is now usually known as CCM3,as the third causative gene of cerebral cavernous malformation(CCM).CCM is a neurovascular disease that is characterized by vascular malformations and is associated with headaches,seizures,focal neurological deficits,and cerebral *** PDCD10/CCM3 protein has multiple subcellular localizations and interacts with several multi-protein complexes and signaling *** PDCD10/CCM3 governs many cellular functions,which include cell-to-cell junctions and cytoskeleton organization,cell proliferation and apoptosis,and exocytosis and *** its central role in the maintenance of homeostasis of the cell,dysregulation of PDCD10/CCM3 can result in a wide range of altered cell *** can lead to severe diseases,including CCM,cognitive disability,and several types of ***,we review the multifaceted roles of PDCD10/CCM3 in physiology and pathology,with a focus on its functions beyond CCM.