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3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction

引用

Bio-Design and Manufacturing 2023年第4期6卷 451-463页

作者： Xingyu Gui Zhiyu Peng Ping Song Li Chen Xiujuan Xu Hairui Li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong Li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610041China Analytical and Testing Center Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China Department of Burn and Plastic Surgery West China HospitalSichuan UniversityChengdu 610041China Department of Orthopedics West China HospitalSichuan UniversityChengdu 610041China

At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal *** method has great trauma to patients,poor plasticity and inaccurate ***-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic *** study explored the combination of 3D printing and tissue engineering to precisely reconstruct the ***,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle *** vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage *** vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle *** results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in *** three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in *** autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.

关键词： Microtia 3D printing Polylactic acid(PLA)polymer scaffolds Gelatin methacrylamide cartilage reconstruction

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