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Modifiers of the Effects of Vitamin D Supplementation on cardiometabolic risk factors:A Systematic Review and Meta-Analysis

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Engineering 2024年第11期42卷 99-107页

作者： Peng An Sitong Wan Langrun Wang Tiancheng Xu Teng Xu Yonghui Wang Jin Liu Keji Li Xifan Wang Jingjing He Simin Liu Food Laboratory of Zhongyuan Luohe 462300China School of Food and Health Beijing Technology&Business UniversityBeijing 100048China Institute of Environmental and Operational Medicine Tianjin 300050China Systems Engineering Institute Beijing 100010China Department of Nutrition and Food Hygiene School of Public HealthPeking UniversityBeijing 100191China Department of Obstetrics and Gynecology Columbia UniversityNew YorkNY 10032USA Center for Global cardiometabolic Health Departments of EpidemiologyMedicineand SurgeryBrown UniversityProvidenceRI 02912USA

The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect *** performed a meta-analysis of randomized controlled trials(RCTs)published until March 2024 that reported estimates for the effects of vitamin D supplementation on cardiometabolic factors and relevant baseline covariates of RCT participants.A total of 17656 participants from 99 RCTs were analyzed,and weighted mean differences(95%confidence intervals(CI))for the intervention status were derived using random-effects ***,compared with the placebo,vitamin D supplementation(median dose:3320 international unit(IU)·day^(-1);range 40-120000 IU·day^(-1))had favorable effects on systolic blood pressure(SBP;-2.04(95%CI,-3.50,-0.59)mmHg;1 mmHg=0.133 kPa),diastolic blood pressure(DBP;-3.00(95%CI,-3.61,-2.39)mmHg),total cholesterol(TC;-0.12(95%CI,-0.21,-0.03)mmol·L^(-1)),fasting blood glucose(FBG;-0.13(95%CI,-0.20,-0.05)mmol·L^(-1)),hemoglobin A1C(A1C;-0.09%(95%CI,-0.13%,-0.05%)),and fasting blood insulin(FBI:-7.61(95%CI,-11.93,-3.30)pmol·L^(-1)).The benefits of vitamin D were most evident in trials performed in non-Westerners,participants with baseline 25-hydroxyvitamin D(25[OH]D)lower than 15.0 ng·mL^(-1),non-obese(body mass index(BMI)cardiometabolic health outcomes.

关键词： Vitamin D cardiometabolic risk factors Meta-analysis Ethnocultural differences Obesity

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Association between Residential Greenness and cardiometabolic risk factors among Adults in Rural Xinjiang Uygur Autonomous Region,China:A Cross-Sectional Study

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Biomedical and Environmental Sciences 2024年第10期37卷 1184-1194页

作者： Leyao Jian Bo Yang Rulin Ma Shuxia Guo Jia He Yu Li Yusong Ding Dongsheng Rui Yidan Mao Xin He Xueying Sun Shengyu Liao Heng Guo Department of Public Health Shihezi University School of MedicineShihezi 832000Xinjiang Uygur Autonomous RegionChina Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security the Xinjiang Production and Construction CorpsShihezi 832000Xinjiang Uygur Autonomous RegionChina NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832000Xinjiang Uygur Autonomous RegionChina

Objective This study aimed to explore the relationships between residential greenness and cardiometabolic risk factors among rural adults in Xinjiang Uygur Autonomous Region(Xinjiang)and thus provide a theoretical basis and data support for improving the health of residents in this *** We recruited 9,723 adult rural residents from the 51st Regiment of the Third Division of the Xinjiang Production and Construction Corps in September *** normalized difference vegetation index(NDVI)was used to estimate residential *** generalized linear mixed model(GLMM)was used to examine the association between residential greenness and cardiometabolic risk *** Higher residential greenness was associated with lower cardiometabolic risk factor *** adjustments were made for age,sex,education,and marital status,for each interquartile range(IQR)increase of NDVI500-m,the risk of hypertension was reduced by 10.3%(OR=0.897,95%CI=0.836-0.962),the risk of obesity by 20.5%(OR=0.795,95%CI=0.695-0.910),the risk of type 2 diabetes by 15.1%(OR=0.849,95%CI=0.740-0.974),and the risk of dyslipidemia by 10.5%(OR=0.895,95%CI=0.825-0.971).risk factor aggregation was reduced by 20.4%(OR=0.796,95%CI=0.716-0.885)for the *** analysis showed that NDVI500-m was associated more strongly with hypertension,dyslipidemia,and risk factor aggregation among male *** association of NDVI500-m with type 2 diabetes was stronger among participants with a higher education ***10 and physical activity mediated 1.9%-9.2%of the associations between NDVI500-m and obesity,dyslipidemia,and risk factor *** Higher residential greenness has a protective effect against cardiometabolic risk factors among rural residents in *** the area of green space around residences is an effective measure to reduce the burden of cardiometabolic-related diseases among rural residents in Xinjiang.

关键词： Green space cardiometabolic risk factors Cross-sectional study Rural adults

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Exercise Blood Pressure Response and cardiometabolic risk factors in Middle Aged Women: A MONET Group Study

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World Journal of Cardiovascular Diseases 2016年第6期6卷 157-165页

作者： Joseph Abdulnour Marie-Noëlle Lacroix Pierre Boulay Éric Doucet Martin Brochu Rémi Rabasa-Lhoret Jean-Marc Lavoie Denis Prud’homme School of Human Kinetics Faculty of Health Sciences University of Ottawa Ottawa ON Canada Institut de recherche de l’H?pital Montfort Ottawa ON Canada Faculté des sciences de l’activité physique Université de Sherbrooke Sherbrooke QC Canada Research Centre on Aging Social Services and Health Centre—University Institute of Geriatrics of Sherbrooke Sherbrooke QC Canada Institut de Recherches Cliniques de Montréal (IRCM) Montréal QC Canada Department of Kinesiology Université de Montréal Montréal QC Canada

Objective: To investigate if an exaggerated peak exercise systolic blood pressure (peak ESBP) is associated with alteration of cardiometabolic risk factors and predict future resting hypertension in middle aged women. Methods: Data analysis was performed in 95 healthy normotensive premeno-pausal women at baseline and 84 after 5-year follow-up (age, 49.9 ± 1.9 years;BMI, 23.3 ± 2.2 kg/m2;resting BP, 117/73 ± 11.8/7.6 mmHg). Blood pressure was measured at rest and during a progressive exercise test on treadmill. Women were divided into two groups according to their peak ESBP cardiometabolic risk factors. Finally, baseline peak ESBP was not a significant risk factor for future resting hypertension (OR: 2.96, 95%CI [0.48 - 18.12];P = 0.24). Conclusion: Our results, despite being non significant, are of great interest because in healthy and active premenopausal women, exaggerated peak ESBP is not predictive of future hypertension after 5-year follow-up throughout menopause transition.

关键词： Blood pressure Exercise Blood Pressure Exaggerated Peak Exercise Systolic Blood Pressure Hy-pertension cardiometabolic risk factors

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Percent body fat,but not body mass index,is associated with cardiometabolic risk factors in children and adolescents

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Chronic Diseases and Translational Medicine 2023年第2期9卷 143-153页

作者： Xin He Zhenni Zhu Jiajie Zang Zhengyuan Wang Ping Liao Wenjing Wang Yan Shi Chen Fu Laboratory of Functional Medicine Division of Chronic Non-communicable Diseases and InjuryShanghai Municipal Center for Disease Control and PreventionShanghaiChina Department of Nutrition Hygiene Division of Health Risk Factor Monitoring and ControlShanghai Municipal Center for Disease Control and PreventionShanghaiChina

Background:The epidemic of overweight and obesity has become a worldwide public health *** diseases may originate in *** investigated the association between percent body fat(PBF)measured by the bioelectrical impedance assay and cardiometabolic risk(CMR)in ***:This cross-sectional study involved 3819 subjects(6-17 years old)in *** assessed the association between PBF and body mass index(BMI)with multiple CMR *** examined the risk for cardiometabolic abnormalities attributable to overweight and obesity based on age-and sexspecific PBF Z-scores and BMI Z-scores,***:PBF,but not BMI,was positively associated with multiple CMR factors in males and females except for total cholesterol in females(all prisk difference for cardiometabolic abnormalities attributable to BMI-based obesity ***:PBF but not BMI was associated with *** and obesity categories based on PBF had an increased risk for cardiometabolic abnormalities in children and adolescents.

关键词： adolescents cardiometabolic risk factors children obesity percent body fat

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Interventions of the high-fiber diet and the rope-skipping exercise improve cardiometabolic risk factors and alter gut microbiota in undergraduates: a randomized controlled trial

Interventions of the high-fiber diet and the rope-skipping e...

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中国营养学会第十五届全国营养科学大会

作者： Miao Wu Yanna Zhu Department of Maternal and Child Health School of Public Health Sun Yat-sen University

Elevated dietary fiber intake and physical activity(PA) level affect cardiometabolic function in people with cardiovascular diseases, potentially by modulating gut microbiota. However, results from those intervention research are inconsistent and is lacking in participants at low cardiometabolic risk. This study aimed to investigate the effect of high-fiber diet and the rope-skipping exercise on cardiometabolic risk factors(CRFs) and gut microbiota among undergraduates, then further to explore whether improvements of CRFs were associated with alterations of gut microbiota. Methods We performed the 12-week parallel-design randomized controlled trial during September 2020 and December 2020 in Sun Yat-sen University, China. Total of 96 undergraduates with BMI≥18.5 kg/m2 were assigned randomly to three groups, containing the high-fiber diet(HFD) group, the rope-skipping exercise(RSE) group, and the control group at a 1:1:1 ratio(n=32, respectively). The HFD group was instructed to consume no less than 20 g of dietary fiber per day from diverse resources foods rich in fiber including whole grains, fruits, and vegetables. The RSE group was instructed to jump rope 2000 times per week. Before and after intervention, anthropometric characteristics, biochemical parameters, three-day dietary recalled surveys, exercise records, and fecal samples were assessed and collected in the participants. Anthropometric characteristics included body weight, BMI, body composition, blood pressure, heart rate, and waist circumference. Biochemical parameters included fasting plasma glucose, fasting insulin, lipid profile, hypersensitive C-reactive protein, and uric acid. After 12-wk intervention, analysis of covariance(ANCOVA) was used to examine differences between groups with adjusting for baseline value. The paired t test or Wilcoxon signed rank test was used to compare differences within each group. Fecal gut microbiota composition and inferred function were analyzed by 16 S rRNA sequencin

关键词： dietary fiber exercise cardiometabolic risk factors gut microbiota young adults

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Association between physical activity energy expenditure and cardiometabolic risk factor clustering among Chinese adults in 2015

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Sports Medicine and Health Science 2022年第2期4卷 105-111页

作者： Xiaorong Chen Mei Zhang Limin Wang Zhengjing Huang Wenrong Zhang Jing Wu National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

To understand the association between cardiometabolic risk factor(CMRF)clustering and physical activity(PA)levels,we included 86520 Chinese adults aged 18–64 years having at least one CMRF(hypertension,diabetes,dyslipidemia,or obesity)from the China Chronic Disease and Nutrition Surveillance survey in 2015,a nationally and provincially representative investigation with a multistage clustering sampling ***-reported PA information was collected with the Global Physical Activity Questionnaire through face-to-face *** view of the obesity epidemic in CMRF patients,PA energy expenditure(PAEE)per kilogram body weight was used,and was defined into four categories:(i)inactivity:0 kJ/kg/day;(ii)low activity:0–5 kJ/kg/day;(iii)moderate activity:6–11 kJ/kg/day;and(iv)vigorous activity:≥12 kJ/kg/*** estimated weighted prevalence(95%confidence interval[CI])of having 1,2,3,and 4 CMRFs was 60.57%(59.48%–61.67%),28.10%(27.40%–28.79%),9.82%(9.22%–15.42%)and 1.50%(1.37%–1.63%),*** rate(95%CI)of inactivity,low activity,moderate activity,and vigorous activity was 34.52%(32.69%–36.35%),22.22%(21.37%–23.37%),15.98%(15.38%–16.58%)and 27.28%(26.02%–28.53%),*** those having 2,3 and 4 CMRFs(compared to those having 1 CMRF),the adjusted odds ratio(95%CI)for moderate activity and vigorous activity were 0.91(0.85–0.98)and 0.92(0.85–0.99),0.87(0.80–0.95)and 0.84(0.77–0.92),and 0.77(0.67–0.89)and 0.85(0.72–1.00),*** conclusion,CMRF clustering was a pandemic among Chinese adults in 2015 and was inversely associated with PA ***(in kJ/kg/day)may be introduced into PA management practice,especially for populations with high body weight.

关键词： Physical activity Energy expenditure cardiometabolic risk factors

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Metabolic hypertension:concept and practice

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Frontiers of Medicine 2013年第2期7卷 201-206页

作者： Zhiming Zhu Peijian Wang Shuangtao Ma Center for Hypertension and Metabolic Diseases Department of Hypertension and EndocrinologyDaping HospitalThird Military Medical UniversityChongqing Institute of HypertensionChongqing 400042China Department of Cardiology General Hospital of PLA Chengdu Military Area CommandChengdu 610083China

Hypertension is a serious public health problem *** than 60%of the risk factors for hypertension are associated with metabolic *** abnormalities increase the risk for hypertension and cause high blood *** metabolic disturbances is beneficial for hypertension *** to the importance of metabolic abnormalities in the pathogenesis of hypertension,we propose a concept of metabolic *** this review,we discuss and review the clinical types,pathogenesis,risk evaluation and management of metabolic *** of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations.

关键词： hypertension cardiometabolic risk factors metabolic abnormalities

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Metabolic-associated Fatty Liver Disease(MAFLD):A Multi-systemic Disease Beyond the Liver

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 329-338页

作者： Eda Kaya Yusuf Yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochumGermany Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Liver Research Unit Institute of GastroenterologyMarmara UniversityIstanbulTurkey

Nonalcoholic fatty liver disease(NAFLD)is a multisystemic clinical condition that presents with a wide spectrum of extrahepatic manifestations,such as obesity,type 2 diabetes mellitus,metabolic syndrome,cardiovascular diseases,chronic kidney disease,extrahepatic malignancies,cogni-tive disorders,and polycystic ovarian *** NAFLD patients,the most common mortality etiology is cardiovascular disorders,followed by extrahepatic malignancies,diabetes mellitus,and liver-related ***,the severity of extrahepatic diseases is parallel to the severity of *** clinical practice,awareness of the associations of concomitant diseases is of major importance for initiating prompt and timely screening and multidisciplinary management of the disease *** 2020,a consensus from 22 countries redefined the disease as metabolic(dysfunction)-associated fatty liver disease(MAFLD),which resulted in the redefinition of the corre-sponding *** the patients diagnosed with MAFLD and NAFLD mostly overlap,the MAFLD and NAFLD populations are not *** this review,we compared the associations of key extrahepatic diseases between NAFLD and MAFLD.

关键词： Metabolic diseases Fatty liver Liver fibrosis Diabetes mellitus,type 2 cardiometabolic risk factors

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Association of education with cholelithiasis and mediating effects of cardiometabolic factors:A Mendelian randomization study

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World Journal of Clinical Cases 2024年第20期12卷 4272-4288页

作者： Chang-Lei Li Yu-Kun Liu Ying-Ying Lan Zu-Sen Wang Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Oncology Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266002Shandong ProvinceChina

BACKGROUND Education,cognition,and intelligence are associated with cholelithiasis occurrence,yet which one has a prominent effect on cholelithiasis and which cardiometabolic risk factors mediate the causal relationship remain *** To explore the causal associations between education,cognition,and intelligence and cholelithiasis,and the cardiometabolic risk factors that mediate the *** Applying genome-wide association study summary statistics of primarily European individuals,we utilized two-sample multivariable Mendelian randomization to estimate the independent effects of education,intelligence,and cognition on cholelithiasis and cholecystitis(FinnGen study,37041 and 11632 patients,respectively;n=486484 participants)and performed two-step Mendelian randomization to evaluate 21 potential mediators and their mediating effects on the relationships between each exposure and *** Inverse variance weighted Mendelian randomization results from the FinnGen consortium showed that genetically higher education,cognition,or intelligence were not independently associated with cholelithiasis and cholecystitis;when adjusted for cholelithiasis,higher education still presented an inverse effect on cholecystitis[odds ratio:0.292(95%CI:0.171-0.501)],which could not be induced by cognition or *** out of 21 cardiometabolic risk factors were perceived as mediators of the association between education and cholelithiasis,including body mass index(20.84%),body fat percentage(40.3%),waist circumference(44.4%),waist-to-hip ratio(32.9%),and time spent watching television(41.6%),while time spent watching television was also a mediator from cognition(20.4%)and intelligence to cholelithiasis(28.4%).All results were robust to sensitivity *** Education,cognition,and intelligence all play crucial roles in the development of cholelithiasis,and several cardiometabolic mediators have been identified for prevention of choleli

关键词： Cholelithiasis Mendelian randomization Mediation analysis Education attainment cardiometabolic risk factors Cognition Intelligence

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Obstructive Sleep Apnea Syndrome is Associated with Metabolic Syndrome among Adolescents and Youth in Beijing： Data from Beijing Child and Adolescent Metabolic Syndrome Study

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Chinese Medical Journal 2015年第17期128卷 2278-2283页

作者： Xiao-Xue Qu Issy C Esangbedo Xiu-Juan Zhang Shu-Jun Liu Lian-Xia Li Shan Gao Ming Li Department of Endocrinology Chaoyang Hospital Capital Medical University Beijing 100043 China Health Weight Program Clinic Children's Hospital of Philadelphia Peielman School of Medicine at University of Pennsylvania USA Department of Endocrinology Key Laboratory of Endocrinology Ministry of Health Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Obstructive sleep apnea （OSA） syndrome has a negative impact on the health of millions of adolescents and youth. The aim of this study was to evaluate the associations of OSA syndrome with obesity and cardiometabolic risk factors among adolescents and youth at risk for metabolic syndrome （MS）.Methods： A total of 558 subjects aged 14-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome Study. Each underwent a 2-h oral glucose tolerance test （OGTT）, echocardiography, and liver ultrasonography. Anthropometric measures, blood levels of glucose, lipids, and liver enzymes were assessed. Subjects with high or low risk for OSA were identified by Berlin Questionnaire （BQ）. Results： Among the subjects in obesity, 33.7% of whom were likely to have OSAby BQ. Subjects with high risk for OSA had higher neck and waist circumference and fat mass percentage compared to those with low risk for OSA （P 〈 0.001 ）. Moreover, significant differences in levels of lipids, glucose after OGTT, and liver enzymes, as well as echocardiographic parameters were found between the two groups with high or low risk for OSA （P 〈 0.05）. The rates of nonalcoholic fatty liver disease （71.0% vs. 24.2%）, MS （38.9% vs. 7.0%）, and its components in high-risk group were significantly higher than in low-risk group. Conclusions： The prevalence of OSA by BQ was high in obese adolescents and youth. A high risk for OSA indicates a high cardiometabolic risk. Mechanisms mediating the observed associations require further investigation.

关键词： Adolescents cardiometabolic risk factors Obesity Obstructive Sleep Apnea Syndrome Youth

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