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Chronic Diseases and Translational Medicine 2023年第2期9卷 143-153页

作者： Xin He Zhenni Zhu Jiajie Zang Zhengyuan Wang Ping Liao Wenjing Wang Yan Shi Chen Fu Laboratory of Functional Medicine Division of Chronic Non-communicable Diseases and InjuryShanghai Municipal Center for Disease Control and PreventionShanghaiChina Department of Nutrition Hygiene Division of Health Risk Factor Monitoring and ControlShanghai Municipal Center for Disease Control and PreventionShanghaiChina

Background:The epidemic of overweight and obesity has become a worldwide public health problem.cardiometabolic diseases may originate in childhood.We investigated the association between percent body fat(PBF)measured by the bioelectrical impedance assay and cardiometabolic risk(CMR)in pediatrics.Methods:This cross-sectional study involved 3819 subjects(6-17 years old)in Shanghai.We assessed the association between PBF and body mass index(BMI)with multiple CMR factors.We examined the risk for cardiometabolic abnormalities attributable to overweight and obesity based on age-and sexspecific PBF Z-scores and BMI Z-scores,respectively.Results:PBF,but not BMI,was positively associated with multiple CMR factors in males and females except for total cholesterol in females(all prisk difference for cardiometabolic abnormalities attributable to BMI-based obesity categories.Conclusions:PBF but not BMI was associated with CMR.Overweight and obesity categories based on PBF had an increased risk for cardiometabolic abnormalities in children and adolescents.

关键词： adolescents cardiometabolic risk factors children obesity percent body fat

Exercise Blood Pressure Response and cardiometabolic risk factors in Middle Aged Women: A MONET Group Study

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World Journal of Cardiovascular Diseases 2016年第6期6卷 157-165页

作者： Joseph Abdulnour Marie-Noëlle Lacroix Pierre Boulay Éric Doucet Martin Brochu Rémi Rabasa-Lhoret Jean-Marc Lavoie Denis Prud’homme School of Human Kinetics Faculty of Health Sciences University of Ottawa Ottawa ON Canada Institut de recherche de l’H?pital Montfort Ottawa ON Canada Faculté des sciences de l’activité physique Université de Sherbrooke Sherbrooke QC Canada Research Centre on Aging Social Services and Health Centre—University Institute of Geriatrics of Sherbrooke Sherbrooke QC Canada Institut de Recherches Cliniques de Montréal (IRCM) Montréal QC Canada Department of Kinesiology Université de Montréal Montréal QC Canada

Objective: To investigate if an exaggerated peak exercise systolic blood pressure (peak ESBP) is associated with alteration of cardiometabolic risk factors and predict future resting hypertension in middle aged women. Methods: Data analysis was performed in 95 healthy normotensive premeno-pausal women at baseline and 84 after 5-year follow-up (age, 49.9 ± 1.9 years;BMI, 23.3 ± 2.2 kg/m2;resting BP, 117/73 ± 11.8/7.6 mmHg). Blood pressure was measured at rest and during a progressive exercise test on treadmill. Women were divided into two groups according to their peak ESBP cardiometabolic risk factors. Finally, baseline peak ESBP was not a significant risk factor for future resting hypertension (OR: 2.96, 95%CI [0.48 - 18.12];P = 0.24). Conclusion: Our results, despite being non significant, are of great interest because in healthy and active premenopausal women, exaggerated peak ESBP is not predictive of future hypertension after 5-year follow-up throughout menopause transition.

关键词： Blood pressure Exercise Blood Pressure Exaggerated Peak Exercise Systolic Blood Pressure Hy-pertension cardiometabolic risk factors

Interventions of the high-fiber diet and the rope-skipping exercise improve cardiometabolic risk factors and alter gut microbiota in undergraduates: a randomized controlled trial

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Association between physical activity energy expenditure and cardiometabolic risk factor clustering among Chinese adults in 2015

中国营养学会第十五届全国营养科学大会

作者： Miao Wu Yanna Zhu Department of Maternal and Child Health School of Public Health Sun Yat-sen University

Elevated dietary fiber intake and physical activity(PA) level affect cardiometabolic function in people with cardiovascular diseases, potentially by modulating gut microbiota. However, results from those intervention research are inconsistent and is lacking in participants at low cardiometabolic risk. This study aimed to investigate the effect of high-fiber diet and the rope-skipping exercise on cardiometabolic risk factors(CRFs) and gut microbiota among undergraduates, then further to explore whether improvements of CRFs were associated with alterations of gut microbiota. Methods We performed the 12-week parallel-design randomized controlled trial during September 2020 and December 2020 in Sun Yat-sen University, China. Total of 96 undergraduates with BMI≥18.5 kg/m2 were assigned randomly to three groups, containing the high-fiber diet(HFD) group, the rope-skipping exercise(RSE) group, and the control group at a 1:1:1 ratio(n=32, respectively). The HFD group was instructed to consume no less than 20 g of dietary fiber per day from diverse resources foods rich in fiber including whole grains, fruits, and vegetables. The RSE group was instructed to jump rope 2000 times per week. Before and after intervention, anthropometric characteristics, biochemical parameters, three-day dietary recalled surveys, exercise records, and fecal samples were assessed and collected in the participants. Anthropometric characteristics included body weight, BMI, body composition, blood pressure, heart rate, and waist circumference. Biochemical parameters included fasting plasma glucose, fasting insulin, lipid profile, hypersensitive C-reactive protein, and uric acid. After 12-wk intervention, analysis of covariance(ANCOVA) was used to examine differences between groups with adjusting for baseline value. The paired t test or Wilcoxon signed rank test was used to compare differences within each group. Fecal gut microbiota composition and inferred function were analyzed by 16 S rRNA sequencing. Correlations between changes in CRFs and chan

关键词： dietary fiber exercise cardiometabolic risk factors gut microbiota young adults

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Sports Medicine and Health Science 2022年第2期4卷 105-111页

作者： Xiaorong Chen Mei Zhang Limin Wang Zhengjing Huang Wenrong Zhang Jing Wu National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

To understand the association between cardiometabolic risk factor(CMRF)clustering and physical activity(PA)levels,we included 86520 Chinese adults aged 18–64 years having at least one CMRF(hypertension,diabetes,dyslipidemia,or obesity)from the China Chronic Disease and Nutrition Surveillance survey in 2015,a nationally and provincially representative investigation with a multistage clustering sampling design.Self-reported PA information was collected with the Global Physical Activity Questionnaire through face-to-face interviews.In view of the obesity epidemic in CMRF patients,PA energy expenditure(PAEE)per kilogram body weight was used,and was defined into four categories:(i)inactivity:0 kJ/kg/day;(ii)low activity:0–5 kJ/kg/day;(iii)moderate activity:6–11 kJ/kg/day;and(iv)vigorous activity:≥12 kJ/kg/day.The estimated weighted prevalence(95%confidence interval[CI])of having 1,2,3,and 4 CMRFs was 60.57%(59.48%–61.67%),28.10%(27.40%–28.79%),9.82%(9.22%–15.42%)and 1.50%(1.37%–1.63%),respectively.The rate(95%CI)of inactivity,low activity,moderate activity,and vigorous activity was 34.52%(32.69%–36.35%),22.22%(21.37%–23.37%),15.98%(15.38%–16.58%)and 27.28%(26.02%–28.53%),respectively.For those having 2,3 and 4 CMRFs(compared to those having 1 CMRF),the adjusted odds ratio(95%CI)for moderate activity and vigorous activity were 0.91(0.85–0.98)and 0.92(0.85–0.99),0.87(0.80–0.95)and 0.84(0.77–0.92),and 0.77(0.67–0.89)and 0.85(0.72–1.00),respectively.In conclusion,CMRF clustering was a pandemic among Chinese adults in 2015 and was inversely associated with PA level.PAEE(in kJ/kg/day)may be introduced into PA management practice,especially for populations with high body weight.

关键词： Physical activity Energy expenditure cardiometabolic risk factors

Metabolic-associated Fatty Liver Disease(MAFLD):A Multi-systemic Disease Beyond the Liver

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 329-338页

作者： Eda Kaya Yusuf Yilmaz Department of Internal Medicine Ruhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochumGermany Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Liver Research Unit Institute of GastroenterologyMarmara UniversityIstanbulTurkey

Nonalcoholic fatty liver disease(NAFLD)is a multisystemic clinical condition that presents with a wide spectrum of extrahepatic manifestations,such as obesity,type 2 diabetes mellitus,metabolic syndrome,cardiovascular diseases,chronic kidney disease,extrahepatic malignancies,cogni-tive disorders,and polycystic ovarian syndrome.Among NAFLD patients,the most common mortality etiology is cardiovascular disorders,followed by extrahepatic malignancies,diabetes mellitus,and liver-related complications.Furthermore,the severity of extrahepatic diseases is parallel to the severity of NAFLD.In clinical practice,awareness of the associations of concomitant diseases is of major importance for initiating prompt and timely screening and multidisciplinary management of the disease spectrum.In 2020,a consensus from 22 countries redefined the disease as metabolic(dysfunction)-associated fatty liver disease(MAFLD),which resulted in the redefinition of the corre-sponding population.Although the patients diagnosed with MAFLD and NAFLD mostly overlap,the MAFLD and NAFLD populations are not identical.In this review,we compared the associations of key extrahepatic diseases between NAFLD and MAFLD.

关键词： Metabolic diseases Fatty liver Liver fibrosis Diabetes mellitus,type 2 cardiometabolic risk factors

Metabolic hypertension:concept and practice

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Frontiers of Medicine 2013年第2期7卷 201-206页

作者： Zhiming Zhu Peijian Wang Shuangtao Ma Center for Hypertension and Metabolic Diseases Department of Hypertension and EndocrinologyDaping HospitalThird Military Medical UniversityChongqing Institute of HypertensionChongqing 400042China Department of Cardiology General Hospital of PLA Chengdu Military Area CommandChengdu 610083China

Hypertension is a serious public health problem worldwide.More than 60%of the risk factors for hypertension are associated with metabolic disturbances.Metabolic abnormalities increase the risk for hypertension and cause high blood pressure.Improving metabolic disturbances is beneficial for hypertension treatment.Due to the importance of metabolic abnormalities in the pathogenesis of hypertension,we propose a concept of metabolic hypertension.In this review,we discuss and review the clinical types,pathogenesis,risk evaluation and management of metabolic hypertension.Elucidation of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations.

关键词： hypertension cardiometabolic risk factors metabolic abnormalities

Obstructive Sleep Apnea Syndrome is Associated with Metabolic Syndrome among Adolescents and Youth in Beijing： Data from Beijing Child and Adolescent Metabolic Syndrome Study

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Chinese Medical Journal 2015年第17期128卷 2278-2283页

作者： Xiao-Xue Qu Issy C Esangbedo Xiu-Juan Zhang Shu-Jun Liu Lian-Xia Li Shan Gao Ming Li Department of Endocrinology Chaoyang Hospital Capital Medical University Beijing 100043 China Health Weight Program Clinic Children's Hospital of Philadelphia Peielman School of Medicine at University of Pennsylvania USA Department of Endocrinology Key Laboratory of Endocrinology Ministry of Health Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Obstructive sleep apnea （OSA） syndrome has a negative impact on the health of millions of adolescents and youth. The aim of this study was to evaluate the associations of OSA syndrome with obesity and cardiometabolic risk factors among adolescents and youth at risk for metabolic syndrome （MS）.Methods： A total of 558 subjects aged 14-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome Study. Each underwent a 2-h oral glucose tolerance test （OGTT）, echocardiography, and liver ultrasonography. Anthropometric measures, blood levels of glucose, lipids, and liver enzymes were assessed. Subjects with high or low risk for OSA were identified by Berlin Questionnaire （BQ）. Results： Among the subjects in obesity, 33.7% of whom were likely to have OSAby BQ. Subjects with high risk for OSA had higher neck and waist circumference and fat mass percentage compared to those with low risk for OSA （P 〈 0.001 ）. Moreover, significant differences in levels of lipids, glucose after OGTT, and liver enzymes, as well as echocardiographic parameters were found between the two groups with high or low risk for OSA （P 〈 0.05）. The rates of nonalcoholic fatty liver disease （71.0% vs. 24.2%）, MS （38.9% vs. 7.0%）, and its components in high-risk group were significantly higher than in low-risk group. Conclusions： The prevalence of OSA by BQ was high in obese adolescents and youth. A high risk for OSA indicates a high cardiometabolic risk. Mechanisms mediating the observed associations require further investigation.

关键词： Adolescents cardiometabolic risk factors Obesity Obstructive Sleep Apnea Syndrome Youth

The effect of puerarin on subclinical atherosclerosis and insulin resistance in patients with active rheumatoid arthritis

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The effect of puerarin on subclinical atherosclerosis and in...