Metabolic-associated Fatty Liver Disease(MAFLD):A Multi-systemic Disease Beyond the Liver

作     者：Eda Kaya Yusuf Yilmaz Eda Kaya;Yusuf Yilmaz

作者机构：Department of Internal MedicineRuhr University BochumUniversity Hospital Knappschaftskrankenhaus BochumBochumGermany Department of GastroenterologySchool of MedicineMarmara UniversityIstanbulTurkey Liver Research UnitInstitute of GastroenterologyMarmara UniversityIstanbulTurkey 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2022年第10卷第2期

页      面：329-338页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Metabolic diseases Fatty liver Liver fibrosis Diabetes mellitus,type 2 Cardiometabolic risk factors 

摘      要：Nonalcoholic fatty liver disease(NAFLD)is a multisystemic clinical condition that presents with a wide spectrum of extrahepatic manifestations,such as obesity,type 2 diabetes mellitus,metabolic syndrome,cardiovascular diseases,chronic kidney disease,extrahepatic malignancies,cogni-tive disorders,and polycystic ovarian *** NAFLD patients,the most common mortality etiology is cardiovascular disorders,followed by extrahepatic malignancies,diabetes mellitus,and liver-related ***,the severity of extrahepatic diseases is parallel to the severity of *** clinical practice,awareness of the associations of concomitant diseases is of major importance for initiating prompt and timely screening and multidisciplinary management of the disease *** 2020,a consensus from 22 countries redefined the disease as metabolic(dysfunction)-associated fatty liver disease(MAFLD),which resulted in the redefinition of the corre-sponding *** the patients diagnosed with MAFLD and NAFLD mostly overlap,the MAFLD and NAFLD populations are not *** this review,we compared the associations of key extrahepatic diseases between NAFLD and MAFLD.