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cardiac resident macrophages: Spatiotemporal distribution, development, physiological functions, and their translational potential on cardiac diseases

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1483-1493页

作者： Jing Jin Yurou Wang Yueqin Liu Subrata Chakrabarti Zhaoliang Su International Genome Center Jiangsu UniversityZhenjiang 212013China Institute for Medical Immunology Jiangsu UniversityZhenjiang 212013China Center Laboratory the Fourth People's Hospital of ZhenjiangZhenjiang 212008China Department of Pathology and Laboratory Medicine Western UniversityLondonOntario N6A 5C1Canada

cardiac resident macrophages (CRMs) are the main population of cardiac immune cells. The role of these cells in regeneration, functional remodeling, and repair after cardiac injury is always the focus of research. However, in recent years, their dynamic changes and contributions in physiological states have a significant attention. CRMs have specific phenotypes and functions in different cardiac chambers or locations of the heart and at different stages. They further show specific differentiation and development processes. The present review will summarize the new progress about the spatiotemporal distribution, potential developmental regulation, and their roles in cardiac development and aging as well as the translational potential of CRMs on cardiac diseases. Of course, the research tools for CRMs, their respective advantages and disadvantages, and key issues on CRMs will further be discussed.

关键词： cardiac resident macrophages Spatiotemporal distribution cardiac development cardiac homeostasis Physiological functions Research tools Clinical translation Transcriptional characteristics

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Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1-Notch1

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Acta Pharmaceutica Sinica B 2023年第1期13卷 128-141页

作者： Rong Chen Shiqing Zhang Fang Liu Lin Xia Chong Wang Siamak Sandoghchian Shotorbani Huaxi Xu Subrata Chakrabarti Tianqing Peng Zhaoliang Su International Genome Center Jiangsu UniversityZhenjiang 212013China Institute for Medical Immunology Jiangsu UniversityZhenjiang 212013China Department of Laboratory Medicine Affiliated Hospital of Jiangsu UniversityZhenjiang 212001China Department of Immunology Tabriz University of Medical SciencesTabriz ***Iran Lawson Health Research Institute London Health Sciences CentreLondonOntario N6A 5w9Canada Department of Pathology and Laboratory Medicine Western UniversityLondonOntario N6A 5CICanada

cardiac-resident macrophages(CRMs)play important roles in homeostasis,cardiac function,and remodeling.Although CRMs play critical roles in cardiac regeneration of neonatal mice,their roles are yet to be fully elucidated.Therefore,this study aimed to investigate the dynamic changes of CRMs during cardiac ontogeny and analyze the phenotypic and functional properties of CRMs in the promotion of cardiac regeneration.During mouse cardiac ontogeny,four CRM subsets exist successively:CX3CR1+CCR2-Ly6C-MHCII-(MP1),CX3CR1lowCCR2lowLy6C-MHCII-(MP2),CX3CR1-CCR2+Ly6C+MHCII-(MP3),and CX3CR1+CCR2-Ly6C-MHCII+(MP4).MP1 cluster has different derivations(yolk sac,fetal liver,and bone marrow)and multiple functions population.Embryonic and neonatal-derived-MP1 directly promoted cardiomyocyte proliferation through Jagged-1-Notch1 axis and significantly ameliorated cardiac injury following myocardial infarction.MP2/3 subsets could survive throughout adulthood.MP4,the main population in adult mouse hearts,contributed to inflammation.During ontogeny,MP1 can convert into MP4 triggered by changes in the cellular redox state.These findings delineate the evolutionary dynamics of CRMs under physiological conditions and found direct evidence that embryonic and neonatal-derived CRMs regulate cardiomyocyte proliferation.Our findings also shed light on cardiac repair following injury.

关键词： cardiac resident macrophages cardiac regeneration cardiac injury Cardiomyocyte proliferation Myocardial infarction

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Renewal of CX3CR1+CCR2-MHCII-Postn+CRMs in response to environmental cues abrogated the potential of promoting cardiac regeneration

Renewal of CX3CR1+CCR2-MHCII-Postn+CRMs in response to envir...

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第十四届全国免疫学学术大会

作者：张士清 Rong Chen Lin Xia Fang Liu Zhaoliang Su 江苏大学 International Genome Center of Jiangsu University

cardiac-resident macrophages(CRMs) play important roles in homeostasis, cardiac function, and remodeling. Published data indicated that there are four CRMs existence in adult heart and that CRMs are associated with regeneration in neonatal mice, there are no directly data to address it. Therefore, this study aimed to investigate dynamic changes in CRMs during cardiac ontogeny under physiological conditions and analyze phenotypic and functional properties of CRMs in promotion of cardiac regeneration. Four CRM subsets exist successively: MP1-4. MP2/3 can survive throughout life. MP1 is a transient population, a novel subtype postn+in MP1 facilitates regeneration. MP4, main population in adult hearts, contributes to inflammation. During ontogeny, MP1s are replenished by MP4s triggered by changes in redox state, and because of this conversion, cardiomyocytes lose proliferative ability. These findings delineated the changes’ process and dynamics of CRMs under physiological conditions.

关键词： cardiac resident macrophages cardiac regeneration cardiac injury

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