Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1-Notch1

作     者：Rong Chen Shiqing Zhang Fang Liu Lin Xia Chong Wang Siamak Sandoghchian Shotorbani Huaxi Xu Subrata Chakrabarti Tianqing Peng Zhaoliang Su 

作者机构：International Genome CenterJiangsu UniversityZhenjiang 212013China Institute for Medical ImmunologyJiangsu UniversityZhenjiang 212013China Department of Laboratory MedicineAffiliated Hospital of Jiangsu UniversityZhenjiang 212001China Department of ImmunologyTabriz University of Medical SciencesTabriz ***Iran Lawson Health Research InstituteLondon Health Sciences CentreLondonOntario N6A 5w9Canada Department of Pathology and Laboratory MedicineWestern UniversityLondonOntario N6A 5CICanada 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2023年第13卷第1期

页      面：128-141页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(Grant No.81871244) Primary Research&Development Plan of Jiangsu Province(BE2019700,China) Jiangsu Province“333”project(BRA2018016,China) six talent peaks project in Jiangsu Province(2019-WSN-122,China) Projects of International Cooperation from Jiangsu(BX2019100,China) international cooperation and exchange from Zhenjiang(GJ2020010,China) key funds from health commission of jiangsu(ZD2021009,China) 

主　　题：Cardiac resident macrophages Cardiac regeneration Cardiac injury Cardiomyocyte proliferation Myocardial infarction 

摘      要：Cardiac-resident macrophages(CRMs)play important roles in homeostasis,cardiac function,and *** CRMs play critical roles in cardiac regeneration of neonatal mice,their roles are yet to be fully ***,this study aimed to investigate the dynamic changes of CRMs during cardiac ontogeny and analyze the phenotypic and functional properties of CRMs in the promotion of cardiac *** mouse cardiac ontogeny,four CRM subsets exist successively:CX3CR1+CCR2-Ly6C-MHCII-(MP1),CX3CR1lowCCR2lowLy6C-MHCII-(MP2),CX3CR1-CCR2+Ly6C+MHCII-(MP3),and CX3CR1+CCR2-Ly6C-MHCII+(MP4).MP1 cluster has different derivations(yolk sac,fetal liver,and bone marrow)and multiple functions *** and neonatal-derived-MP1 directly promoted cardiomyocyte proliferation through Jagged-1-Notch1 axis and significantly ameliorated cardiac injury following myocardial ***2/3 subsets could survive throughout ***4,the main population in adult mouse hearts,contributed to *** ontogeny,MP1 can convert into MP4 triggered by changes in the cellular redox *** findings delineate the evolutionary dynamics of CRMs under physiological conditions and found direct evidence that embryonic and neonatal-derived CRMs regulate cardiomyocyte *** findings also shed light on cardiac repair following injury.