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Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults

Global Health Journal 2022年第1期6卷 6-18页

作者： Lingyan Liu Yutong Zhu Hongbing Xu Yang Wang Tong Wang Qian Zhao Yi Zhang Jie Chen Shengcong Liu Tieci Yi Rongshan Wu Shuo Liu Xiaoming Song Jianping Li Wei Huang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Peking University Institute of Environmental Medicine Peking UniversityBeijing 100191China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science CenterPeking UniversityBeijing 100191China Department of Prevention and Health Care Hospital of Health Science CenterPeking UniversityBeijing 100191 China Institute for Risk Assessment Sciences University Medical Centre UtrechtUniversity of UtrechtP.O.Box 801253508 TC Utrechtthe Netherlands Department of Cardiology Peking University First HospitalBeijing 100034China

Objective The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains *** this study,we aim to examine the impacts of O3 exposure on cardiac arrhythmias and potential pathways involved through autonomic dysfunction and myocardial *** Seventy-three non-smoking healthy adults were followed with 4 repeated measurements of 24-hour ambulatory arrhythmias,heart rate variability,ST-segment deviation,and blood pressure(BP)in Beijing,China,2014‒*** additive mixed models coupled with distributed lag nonlinear models were constructed to evaluate the associations and potential interlinks between O3 exposure and outcome *** During the study period,24-hour average concentrations of ambient O3 were 47.4µg/m3(ranging from 1.0 to 165.9µg/m3).Increased risks of premature ventricular contraction and ventricular tachycardia were associated with interquartile range increases in O3 exposure during the last 5 days before each participant's clinic visit,with relative risks of 2.14(95%confidence interval[CI]:1.95 to 2.32)and 5.47(95%CI:3.51 to 7.43),*** analyses further showed that sympathetic activation,parasympathetic inhibition,and elevated BP levels,as well as heightened risks of ST-segment depression could mediate up to 47.74%of the risks of arrhythmias attributable to O3 *** Our results suggest that short-term exposure to ambient O3 could prompt the genesis of arrhythmias partially through worsening autonomic function and myocardial burden.

关键词： Ozone cardiac arrhythmias cardiac autonomic function Myocardial injury Panel study

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Expert Consensus on Wenxin Granule for Treatment of cardiac arrhythmias

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Chinese Medical Journal 2017年第2期130卷 203-210页

作者： Guo, Ji-Hong Yan, Gan-Xin Wu, Lin Zhao, Bu-Chang Wang, Yi-Min Gu, Fu-Sheng Zhou, Yu-Ping Antzelevitch, Charles Guo, Jing-Xuan Yang, Jie-Fu Yang, Xin-Chun Ding, Yan-Sheng Zhang, Ping Zhang, Hai-Cheng Liu, Hong-Xu Lu, Wei-Xing Xing, Yan-Wei Fan, Jian-Feng Ze, Feng Li, Guang-ping Li, Yi-Gang Liao, De-Ning Xue, Xiao-Lin Heart Rhythm Society of the Chinese Society of Biomedical Engineering Nao Xin Tong Zhi Committee ol the Chinese Association of Integralive Medicine

INTRODUCTIONAntiarrhythmic drugs remain a critically important component of the approach to therapy of cardiac arrhythmias. Over the past 20 years, despite their antiarrhythmic efficacy in many pathological settings, Class Ⅰ and Ⅲ antiarrhythmic drugs have been shown to be associated with the development of proarrhythmias and an increase in the likelihood of causing higher mortality by inducing torsade de pointes ventricular tachycardia and other serious adverse reactions. Consequently, the development of safe and effective antiarrhythmic regimens remains a primary focus of contemporary cardiovascular research.

关键词： cardiac arrhythmias Treatment Wenxin Granule

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Automatic Classification of cardiac arrhythmias Based on Hybrid Features and Decision Tree Algorithm

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International Journal of Automation and computing 2020年第4期17卷 551-561页

作者： Santanu Sahoo Asit Subudhi Manasa Dash Sukanta Sabut Department of Electronics and Communication Engineering ITERSOA UniversityBhubaneswar 751030India Department of Mathematics Silicon Institute of TechnologyBhubaneswar 751024India School of Electronics Engineering KIIT deemed to be UniversityBhubaneswar 751024India

Accurate classification of cardiac arrhythmias is a crucial task because of the non-stationary nature of electrocardiogram(ECG)*** a life-threatening situation,an automated system is necessary for early detection of beat abnormalities in order to reduce the mortality *** this paper,we propose an automatic classification system of ECG beats based on the multi-domain features derived from the ECG *** experimental study was evaluated on ECG signals obtained from the MIT-BIH Arrhythmia *** feature set comprises eight empirical mode decomposition(EMD)based features,three features from variational mode decomposition(VMD)and four features from RR *** total,15 features are ranked according to a ranker search approach and then used as input to the support vector machine(SVM)and C4.5 decision tree classifiers for classifying six types of arrhythmia *** proposed method achieved best result in C4.5 decision tree classifier with an accuracy of 98.89%compared to cubic-SVM classifier which achieved an accuracy of 95.35%*** accuracy measures,all other parameters such as sensitivity(Se),specificity(Sp)and precision rates of 95.68%,99.28%and 95.8%was achieved better in C4.5 *** the computational time of 0.65 s with an error rate of 0.11 was achieved which is very less compared to *** multi-domain based features with decision tree classifier obtained the best results in classifying cardiac arrhythmias hence the system could be used efficiently in clinical practices.

关键词： Electrocardiogram(ECG) cardiac arrhythmias empirical mode decomposition(EMD) variational mode decomposition(VMD) hybrid features decision tree classifier

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Nonalcoholic Fatty Liver Disease (NAFLD) and Risk of cardiac arrhythmias: A New Aspect of the Liver-heart Axis

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 134-141页

作者： Alessandro Mantovani Section of Endocrinology Diabetes and Metabolism Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona Verona Italy

Nonalcoholic fatty liver disease (NAFLD) is a pathologic condition frequently observed in clinical *** date,the prevalence of NAFLD is approximately 25-30% among adults of the general population in Western countries but increases to approximately 70-75% among patients with type 2 diabetes *** the last decade,accumulating evidence has clearly demonstrated that patients with NAFLD have not only an increased liver-related morbidity and mortality but also an increased risk of fatal and non-fatal cardiovascular *** particular,several studies have documented the existence of an independent association among NAFLD and cardiac changes in structure and function in both non-diabetic and diabetic *** addition,mounting evidence also suggests that there is a strong relationship between NAFLD and cardiac arrhythmias,such as atrial fibrillation,QTc prolongation and ventricular *** is of clinical interest,as it could explain,at least in part,the increased risk of death for cardiovascular disease in patients with ***,seeing that cardiovascular disease complications are the leading cause of disability and death in NAFLD patients,the recent European clinical practice guidelines advised to check the cardiovascular system in all patients with *** clinical mini review will briefly describe the increasing body of evidence regarding the association between NAFLD and cardiac arrhythmias,and discuss the potential biological mechanisms underlying this association.

关键词： Nonalcoholic fatty liver disease Cardiovascular disease cardiac arrhythmias cardiac complications

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Repeated atrial arrhythmia induced by cochineal red poisoning:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8184-8191页

作者： Hao Yang Yu-Jiao Wang Bao-Ping Xu Huai-Wen Peng Qing Xu Huai-Bin Yu Department of Intensive Care Unit Anhui Zhongke Gengjiu Hospital Affiliated To Anhui Medical UniversityHefei 230000Anhui ProvinceChina Graduate School Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Department of Intensive Care Unit Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina

BACKGROUND Cochineal red is an organic compound widely used in food,cosmetics,pharmaceuticals,textiles,and other fields due to its excellent safety *** caused by eating foods containing cochineal red is rare,and repeated atrial arrhythmia due to cochineal red poisoning is even *** SUMMARY An 88-year-old Asian female patient was admitted to hospital due to a disturbance of *** hours prior to presentation,the patient consumed 12 eggs containing cochineal red over a period of 2 *** presentation,the patient was in a coma and had a score of 6 on the Glasgow Coma Scale(E2+VT+M4).The patient’s skin and mucous membranes were ***(ECG)revealed rapid atrial fibrillation without any signs of *** prescribed cedilan and fluid replacement for arrhythmia *** after admission,the atrial fibrillation corrected to a normal sinus *** the day 2 of admission,the patient had a sudden atrial flutter accompanied by hemodynamic instability and rapidly declining arterial oxygen saturation between 85%and 90%.The sinus rhythm returned to normal after two electrical *** days after admission,the skin color of the patient returned to normal,and the ECG results were *** patient was transferred out of the intensive care unit and eventually discharged after 12 d in *** the 2-mo follow-up visit,the patient was in good health with no recurrence of *** Although cochineal red is a safe,natural food additive,excessive consumption or occupational exposure can induce cardiac arrhythmias.

关键词： Cochineal red Poisoning cardiac arrhythmias Atrial fibrillation Atrial flutter Case report

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Cystic tumour of the atrioventricular node: case report and literature review

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Forensic Sciences Research 2019年第3期4卷 287-289页

作者： Stephen D.Cohle Spectrum Health Grand RapidsMIUSA

Cystic tumour of the atrioventricular node is the smallest tumour that can cause sudden cardiac *** lesion arises from foregut endodermal rests which become enfolded into the heart during *** causing heart block,the tumour can cause sudden death despite pacemaker *** death in such cases can be caused by arrhythmogenic ectopic foci arising from impaired electrical impulse propagation through the abnormal atrioventricular junction conducting tissue.

关键词： Forensic sciences forensic pathology cystic tumour of the AV node AV node tumour sudden cardiac death cardiac arrhythmias

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