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Detection of human papillomavirus DNA in esophageal carcinoma in Greece

World Journal of Gastroenterology 2015年第8期21卷 2352-2357页

作者： Georgios Georgantis Theodoros Syrakos Theodoros Agorastos Spiridon Miliaras Asterios Gagalis Georgios Tsoulfas Konstantinos Spanos Georgios Marakis 1~(st) Surgical Clinic of the Aristotle University of Thessaloniki Papageorgiou General Hospital 4(th) Department of Gynecology and Obstetrics of the Aristotle University of Thessaloniki Ippokrateio Hospital Department of Endoscopy Papageorgiou Hospital

AIM:To detect human papillomavirus(HPV)in theesophageal mucosa and the possible relationship with esophageal cancer in ***:Forty-nine patients underwent esophagogastroduodenoscopy(EGD)and esophageal biopsy at a university hospital that acts as a referral center for Northern *** of these patients(14 male and 5 female)had esophageal squamous cell carcinoma(ESCC)and 30(15 male and 15 female)did not have any reported esophageal *** assessment was followed by polymerase chain reaction analysis of all the *** demographic data(age,sex,and place of birth)and information regarding smoking habits,alcohol consumption or sexual habits were collected.A method of statistical interference,verification of hypotheses based on homogeneity and independentχ2 test,was ***:From the 49 patients that underwent EGD and biopsy,19 had ESCC and 30 had normal esophageal mucosa,with a mean age of 65.2 *** the prevalence of oncogenic risk factors for esophageal carcinoma,an interesting conclusion was that 78%of the patients used tobacco and almost one-third had multiple sexual partners,whereas only 20%of the patients consumed alcohol,which was not statistically significant,when compared to the control *** the ESCC group,the only two positive samples were among the male patients(2/14 male patients with ESCC,14.5%).No HPV was identified in the control *** predominant HPV types identified were 11 and 31,which have a low malignancy *** presence of HPV DNA in the ESCC group was not statistically significant,95%confidence interval(χ2=3.292,P=0.07).CONCLUSION:This is the first relevant study in Greece,and despite the lack of statistical significance,the issue of HPV infection and ESCC does merit further investigation.

关键词： Esophageal cancer Esophageal squamous cell carcino

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Prognostic significance of serum gammaglutamyl transferase before transcatheter arterial chemoembolization in patients with hepatitis C virusrelated hepatocellular carcinoma

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China Medical Abstracts(Internal Medicine) 2016年第2期33卷 32-33页

作者：常中飞 Dept TCM Beijing Shijingshan HospShijingshan Teach HospCapital Med Univ

Objective To evaluate the prognostic significance of serum GGT in patients with hepatitis C virus-related hepatocellular carcinoma(HCV-HCC)treated with transcatheter arterial chemoembolization(TACE).Methods The clinic... 详细信息

关键词： transcatheter prognostic univariate fetoprotein prognosis pretreatment affecting carcino multivariate

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Correlation between Ki-67 and early recurrence of hepatocellular carcinoma after radical resection

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China Medical Abstracts(Internal Medicine) 2014年第3期31卷 180-181页

作者：郑苏苏 Dept Hepatic Oncol Zhongshan HospFudan Univ

Objective To explore the related factors of early recurrence(less than 12 months)of hepatocellular carcinoma(HCC)after radical resection and the expression and significance of Ki-67 in *** From April 2011to August 2012,152 patients with HCC underwent radical resection were *** Ki-67 index was obtained from the report of pathological *** patients were followed up for the condition of

关键词： recurrence Correlation fetoprotein thrombus univariate gression carcino prognostic multivariate preoperative

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Clinical characteristics and prognosis of three rare and poor-prognostic subtypes of primary liver carcinoma

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China Medical Abstracts(Internal Medicine) 2014年第2期31卷 110-111页

作者：李智宇 Dept Abdominal Surg Cancer HospCAMS & PUMC

Objective To explore the clinicopathological features and prognostic factors of three rare and poor-prognostic pathological subtypes of primary liver carcinoma,and to improve the clinical diagnosis and surgical *** A retrospective analysis of clinicopathological data of 69 patients with rare pathological subtypes of primary liver carcinoma,diagnosed by

关键词： prognostic retrospective prognosis postoperative carcino invasion metastasis organs median hilar

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Outcome following incomplete surgical cytoreduction combined with intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 445-454页

作者： Roisin Mary Heaney Conor Shields Jurgen Mulsow Peritoneal Malignancy Institute Mater Misericordiae University Hospital

Cytoreductive surgery combined with intraperitoneal chemotherapy can improve survival in appropriately selected patients with colorectal peritoneal metastases. Outcomes are best in those patients in whom a complete cytoreduction can be achieved. Unresectabledisease is however encountered in approximately one-quarter of patients at laparotomy. The merits, or otherwise, of proceeding with an incomplete cytoreduction in this setting are unclear. We performed a review of published outcomes following incomplete cytoreduction for colorectal peritoneal metastases. Using the electronic databases, Pub Med and MEDLINE, a systematic search of available literature published during the period January 1997 to September 2014 was conducted. Following application of exclusion criteria, 19 papers were identified and included in this review. These comprised fifteen case series, 3 case control studies and one randomised control trial. In the nineteen studies included in this review, 2790 patients underwent cytoreductive surgery with or without intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Of these, 1732(62%) underwent a complete cytoreduction while 986(35%) patients underwent an incomplete cytoreduction. Median survival in the complete cytoreduction group ranged from 11 to 62 mo while survival in the latter group ranged from 2.4 to 32 mo. Of the 986 patients with an incomplete cytoreduction, 331 patients received intraperitoneal chemotherapy and survival in this cohort ranged from 4.5 to 32 mo. An incomplete cytoreduction, with or without intraperitoneal chemotherapy, does not appear to confer a survival benefit. The limited available data points to a palliative benefit in a subset of patients. In the absence of high quality data, the decision as to whether or not to proceed with surgery should be made on an individual patient basis.

关键词： Colorectal carcinoma Peritoneal metastases carcino

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Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer

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World Journal of Gastroenterology 2015年第14期21卷 4240-4247页

作者： Jin-Liang Zhang Hui-Yun Wang Qing Yang Shi-Yong Lin Guang-Yu Luo Rong Zhang Guo-Liang Xu Department of Endoscopy and Laser State Key Laboratory of Oncology in South ChinaGuangdong Esophageal Cancer InstituteNational Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center Department of Medical Oncology Longhua New District Central Hospital of Shenzhen State Key Laboratory of Oncology in South China Guangdong Esophageal Cancer InstituteNational Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center

AIM: To investigate the clinical significance of methylmethanesulfonate sensitivity 19(MMS19) expression in esophageal squamous cell carcinoma(ESCC).METHODS: Between June 2008 and May 2013, specimens from 103 patients who underwent endoscopic biopsy for the diagnosis of ESCC at the endoscopy center of Sun Yat-Sen University Cancer Center were collected; 52 matched-normal esophageal squamous epithelium samples were biopsied as ***19 protein expression was measured by *** the 103 cases of ESCC, 49 received radical surgery following neoadjuvant chemoradiotherapy consisting of concurrent radiation in a total dose of 40 Gy and two cycles of chemotherapy with vinorelbine and *** between MMS19 expression, clinicopathologic characteristics and chemoradiotherapy response were ***: The MMS19 protein could be detected in both the cytoplasm and nucleus of most *** cytoplasmic expression of MMS19 was detected in 63.1% of ESCC samples, whereas high nuclearexpression of MMS19 was found in 35.0%.High cytoplasmic MMS19 expression was associated with regional lymph node metastases(OR = 11.3, 95%CI: 2.3-54.7; P < 0.001) and distant metastases(OR = 13.1, 95%CI: 1.7-103.0; P = 0.002).Furthermore, high cytoplasmic MMS19 expression was associated with a response of ESCC to chemoradiotherapy(OR = 11.5, 95%CI: 3.0-44.5; P < 0.001), with a high cytoplasmic MMS19 expression rates in 79.3% and 25.0% of patients from the good chemoradiotherapy response group and poor response group, *** MMS19 expression did not show any significant association with clinicopathologic characteristics or chemoradiotherapy response in ***: The results of our preliminary study suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in ESCC.

关键词： Chemoradiotherapy Esophageal squamous cell carcino

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Clinico-pathological Analysis of 17 Cases of Broncogenic carcinoma with Intracranial Metastasis

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华西医科大学学报 1989年第2期 140-140页

A total of 1037 cases of lung cancer wereanalysed. Of these 17 cases had intra-cranial m-etastasis, 11 proved by ahtopsy, 6 by *** 55 autopsy cases of bronchogenic carcino-ma, 11 (20％) with intra-cranial metastasis,

关键词： carcinoma carcino cranial metastasis fundus headache

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