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超声造影诊断肝脏上皮样血管内皮细胞瘤二例

中华医学超声杂志（电子版） 2016年第6期13卷 476-478页

作者：张静周翔肖练杨春艳唐小兰四川大学华西医院超声科成都610041

例1患者女性,31岁,因上腹部隐痛不适1周入院。实验室检查：甲胎蛋白（α-fetoprotein,AFP）2.27μg/L,血清CA19-9、CA-125、CA15-3分别为35.71、35.79、6.13 k U/L,癌胚抗原（Carcino-embryonic antigen,CEA）0.54μg/L,碱性磷酸酶（alk... 详细信息

关键词：超声造影 fetoprotein 甲胎蛋白 Carcino 碱性磷酸酶上腹部癌胚抗原门脉期硬化区延迟期

Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer

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World Journal of Gastroenterology 2015年第14期21卷 4240-4247页

作者： Jin-Liang Zhang Hui-Yun Wang Qing Yang Shi-Yong Lin Guang-Yu Luo Rong Zhang Guo-Liang Xu Department of Endoscopy and Laser State Key Laboratory of Oncology in South ChinaGuangdong Esophageal Cancer InstituteNational Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center Department of Medical Oncology Longhua New District Central Hospital of Shenzhen State Key Laboratory of Oncology in South China Guangdong Esophageal Cancer InstituteNational Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center

AIM: To investigate the clinical significance of methylmethanesulfonate sensitivity 19(MMS19) expression in esophageal squamous cell Carcinoma(ESCC).METHODS: Between June 2008 and May 2013, specimens from 103 patients who underwent endoscopic biopsy for the diagnosis of ESCC at the endoscopy center of Sun Yat-Sen University Cancer Center were collected; 52 matched-normal esophageal squamous epithelium samples were biopsied as controls.MMS19 protein expression was measured by immunohistochemistry.Of the 103 cases of ESCC, 49 received radical surgery following neoadjuvant chemoradiotherapy consisting of concurrent radiation in a total dose of 40 Gy and two cycles of chemotherapy with vinorelbine and cisplatin.Relationships between MMS19 expression, clinicopathologic characteristics and chemoradiotherapy response were analyzed.RESULTS: The MMS19 protein could be detected in both the cytoplasm and nucleus of most specimens.High cytoplasmic expression of MMS19 was detected in 63.1% of ESCC samples, whereas high nuclearexpression of MMS19 was found in 35.0%.High cytoplasmic MMS19 expression was associated with regional lymph node metastases(OR = 11.3, 95%CI: 2.3-54.7; P < 0.001) and distant metastases(OR = 13.1, 95%CI: 1.7-103.0; P = 0.002).Furthermore, high cytoplasmic MMS19 expression was associated with a response of ESCC to chemoradiotherapy(OR = 11.5, 95%CI: 3.0-44.5; P < 0.001), with a high cytoplasmic MMS19 expression rates in 79.3% and 25.0% of patients from the good chemoradiotherapy response group and poor response group, respectively.Nuclear MMS19 expression did not show any significant association with clinicopathologic characteristics or chemoradiotherapy response in ESCC.CONCLUSION: The results of our preliminary study suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in ESCC.

关键词： Chemoradiotherapy Esophageal squamous cell Carcino

Outcome following incomplete surgical cytoreduction combined with intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 445-454页

作者： Roisin Mary Heaney Conor Shields Jurgen Mulsow Peritoneal Malignancy Institute Mater Misericordiae University Hospital

Cytoreductive surgery combined with intraperitoneal chemotherapy can improve survival in appropriately selected patients with colorectal peritoneal metastases. Outcomes are best in those patients in whom a complete cytoreduction can be achieved. Unresectabledisease is however encountered in approximately one-quarter of patients at laparotomy. The merits, or otherwise, of proceeding with an incomplete cytoreduction in this setting are unclear. We performed a review of published outcomes following incomplete cytoreduction for colorectal peritoneal metastases. Using the electronic databases, Pub Med and MEDLINE, a systematic search of available literature published during the period January 1997 to September 2014 was conducted. Following application of exclusion criteria, 19 papers were identified and included in this review. These comprised fifteen case series, 3 case control studies and one randomised control trial. In the nineteen studies included in this review, 2790 patients underwent cytoreductive surgery with or without intraperitoneal chemotherapy for peritoneal metastases of colorectal origin. Of these, 1732(62%) underwent a complete cytoreduction while 986(35%) patients underwent an incomplete cytoreduction. Median survival in the complete cytoreduction group ranged from 11 to 62 mo while survival in the latter group ranged from 2.4 to 32 mo. Of the 986 patients with an incomplete cytoreduction, 331 patients received intraperitoneal chemotherapy and survival in this cohort ranged from 4.5 to 32 mo. An incomplete cytoreduction, with or without intraperitoneal chemotherapy, does not appear to confer a survival benefit. The limited available data points to a palliative benefit in a subset of patients. In the absence of high quality data, the decision as to whether or not to proceed with surgery should be made on an individual patient basis.

关键词： Colorectal Carcinoma Peritoneal metastases Carcino

Detection of human papillomavirus DNA in esophageal Carcinoma in Greece

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World Journal of Gastroenterology 2015年第8期21卷 2352-2357页

作者： Georgios Georgantis Theodoros Syrakos Theodoros Agorastos Spiridon Miliaras Asterios Gagalis Georgios Tsoulfas Konstantinos Spanos Georgios Marakis 1~(st) Surgical Clinic of the Aristotle University of Thessaloniki Papageorgiou General Hospital 4(th) Department of Gynecology and Obstetrics of the Aristotle University of Thessaloniki Ippokrateio Hospital Department of Endoscopy Papageorgiou Hospital

AIM:To detect human papillomavirus(HPV)in theesophageal mucosa and the possible relationship with esophageal cancer in Greece.METHODS:Forty-nine patients underwent esophagogastroduodenoscopy(EGD)and esophageal biopsy at a university hospital that acts as a referral center for Northern Greece.Nineteen of these patients(14 male and 5 female)had esophageal squamous cell Carcinoma(ESCC)and 30(15 male and 15 female)did not have any reported esophageal malignancy.Histopathological assessment was followed by polymerase chain reaction analysis of all the samples.Patient demographic data(age,sex,and place of birth)and information regarding smoking habits,alcohol consumption or sexual habits were collected.A method of statistical interference,verification of hypotheses based on homogeneity and independentχ2 test,was used.RESULTS:From the 49 patients that underwent EGD and biopsy,19 had ESCC and 30 had normal esophageal mucosa,with a mean age of 65.2 years.Regarding the prevalence of oncogenic risk factors for esophageal Carcinoma,an interesting conclusion was that 78%of the patients used tobacco and almost one-third had multiple sexual partners,whereas only 20%of the patients consumed alcohol,which was not statistically significant,when compared to the control group.In the ESCC group,the only two positive samples were among the male patients(2/14 male patients with ESCC,14.5%).No HPV was identified in the control group.The predominant HPV types identified were 11 and 31,which have a low malignancy potential.The presence of HPV DNA in the ESCC group was not statistically significant,95%confidence interval(χ2=3.292,P=0.07).CONCLUSION:This is the first relevant study in Greece,and despite the lack of statistical significance,the issue of HPV infection and ESCC does merit further investigation.

关键词： Esophageal cancer Esophageal squamous cell Carcino

Prognostic significance of serum gammaglutamyl transferase before transcatheter arterial chemoembolization in patients with hepatitis C virusrelated hepatocellular Carcinoma

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China Medical Abstracts(Internal Medicine) 2016年第2期33卷 32-33页

作者：常中飞 Dept TCM Beijing Shijingshan HospShijingshan Teach HospCapital Med Univ

Objective To evaluate the prognostic significance of serum GGT in patients with hepatitis C virus-related hepatocellular Carcinoma(HCV-HCC)treated with transcatheter arterial chemoembolization(TACE).Methods The clinic... 详细信息

关键词： transcatheter prognostic univariate fetoprotein prognosis pretreatment affecting Carcino multivariate

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Pancreas

China Medical Abstracts(Internal Medicine) 2012年第3期29卷 172-174页

2012095 Effect of bone marrow mesenchymal stem cells transplantation on intestinal mucosa barrier of acute pancreatitis. SUN Xuecheng(孙学成),et al.Dept Gastroenterol,1st Affil Hosp,Wenzhou Med Coll,

关键词： severity intraductal hundred dimer prothrombin Carcino Pancreas predicting APACHE adenoCarcinoma

Correlation between Ki-67 and early recurrence of hepatocellular Carcinoma after radical resection

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China Medical Abstracts(Internal Medicine) 2014年第3期31卷 180-181页

作者：郑苏苏 Dept Hepatic Oncol Zhongshan HospFudan Univ

Objective To explore the related factors of early recurrence(less than 12 months)of hepatocellular Carcinoma(HCC)after radical resection and the expression and significance of Ki-67 in HCC.Methods From April 2011to August 2012,152 patients with HCC underwent radical resection were collected.The Ki-67 index was obtained from the report of pathological examination.The patients were followed up for the condition of

关键词： recurrence Correlation fetoprotein thrombus univariate gression Carcino prognostic multivariate preoperative

Clinical characteristics and prognosis of three rare and poor-prognostic subtypes of primary liver Carcinoma

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China Medical Abstracts(Internal Medicine) 2014年第2期31卷 110-111页

作者：李智宇 Dept Abdominal Surg Cancer HospCAMS & PUMC

Objective To explore the clinicopathological features and prognostic factors of three rare and poor-prognostic pathological subtypes of primary liver Carcinoma,and to improve the clinical diagnosis and surgical treatment.Methods A retrospective analysis of clinicopathological data of 69 patients with rare pathological subtypes of primary liver Carcinoma,diagnosed by

关键词： prognostic retrospective prognosis postoperative Carcino invasion metastasis organs median hilar

Liver and Biliary System

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China Medical Abstracts(Internal Medicine) 2011年第3期28卷 171-175页

2011349 Expression of Raf kinase inhibitor protein and its significance in invasion and metastasis of hepatocellular Carcinoma. WU Xiaohui(吴曉慧),et al.Dept Hepatobiliary Surg,4th Hosp,Hebei Med Univ,Shijiazhuang 050011.Abstract:Objective To investigate the expression of RKIP,p65 and pERK in hepatocellular Carcinoma(HCC) and their correlation with

关键词： invasion metastasis moderately Hebei inactive Carcino bilirubin profiling poorly differentiated