Detection of human papillomavirus DNA in esophageal carcinoma in Greece

作     者：Georgios Georgantis Theodoros Syrakos Theodoros Agorastos Spiridon Miliaras Asterios Gagalis Georgios Tsoulfas Konstantinos Spanos Georgios Marakis 

作者机构：1~(st) Surgical Clinic of the Aristotle University of Thessaloniki Papageorgiou General Hospital 4(th) Department of Gynecology and Obstetrics of the Aristotle University of Thessaloniki Ippokrateio Hospital Department of Endoscopy Papageorgiou Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第8期

页      面：2352-2357页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Esophageal cancer Esophageal squamous cell carcino 

摘      要：AIM:To detect human papillomavirus(HPV)in theesophageal mucosa and the possible relationship with esophageal cancer in ***:Forty-nine patients underwent esophagogastroduodenoscopy(EGD)and esophageal biopsy at a university hospital that acts as a referral center for Northern *** of these patients(14 male and 5 female)had esophageal squamous cell carcinoma(ESCC)and 30(15 male and 15 female)did not have any reported esophageal *** assessment was followed by polymerase chain reaction analysis of all the *** demographic data(age,sex,and place of birth)and information regarding smoking habits,alcohol consumption or sexual habits were collected.A method of statistical interference,verification of hypotheses based on homogeneity and independentχ2 test,was ***:From the 49 patients that underwent EGD and biopsy,19 had ESCC and 30 had normal esophageal mucosa,with a mean age of 65.2 *** the prevalence of oncogenic risk factors for esophageal carcinoma,an interesting conclusion was that 78%of the patients used tobacco and almost one-third had multiple sexual partners,whereas only 20%of the patients consumed alcohol,which was not statistically significant,when compared to the control *** the ESCC group,the only two positive samples were among the male patients(2/14 male patients with ESCC,14.5%).No HPV was identified in the control *** predominant HPV types identified were 11 and 31,which have a low malignancy *** presence of HPV DNA in the ESCC group was not statistically significant,95%confidence interval(χ2=3.292,P=0.07).CONCLUSION:This is the first relevant study in Greece,and despite the lack of statistical significance,the issue of HPV infection and ESCC does merit further investigation.