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Acute Toxicity Test of Abrus cantoniensis Hance Extract

Medicinal Plant 2019年第6期10卷 32-34页

作者： Xuankai HU Haichun LONG Qiao WEI Yuxia WEI Jinli HUANG Tingshu LI Zhidong LEI Suoyi HUANG Youjiang Medical University for Nationalities Baise 533000China Key Laboratory of Guangxi’s Colleges for the Study of Characteristic Ethnic Medicine in Youjiang River Basin Baise 533000China

[Objectives]To investigate the acute toxicity of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract to mice.[Methods]The medium lethal dose(LD50)in mice could not be determined,so the maximum dose method was used for *** were not fed but allowed to drink water for 16 h before the *** were 74 SPF Kunming Mice,half male and half female,and it was divided into extract group and blank control *** toxicity and death were recorded after intragastric administration and regular close *** any mice died,the dead mice were *** changes of heart,liver,spleen,lung,kidney,brain,stomach,small intestine and other organs were observed with the naked *** the end of the 14 d observation period,the surviving mice in each group were killed and *** gross pathological changes of the main organs were observed with the naked eye according to the same method mentioned above.[Results]There were no obvious toxic symptoms and no death in the mice.[Conclusions]The maximum doses of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract in mice were 1.61,1.71,1.65 and 1.79 g/L,*** it was found that the quarterly tests of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract suggested that the medicine was safe.

关键词： Abrus cantoniensis Hance Acute toxicity Maximum dosage

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Comparison of Extraction Methods for Total Alkaloids from Abrus cantoniensis Hance

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Medicinal Plant 2017年第2期8卷 19-21页

作者： Mengyao LIN Qiumeng WEI Xiaoxia HUANG Jiaming WANG Suoyi HUANG Luyao WANG Yan LIU Gongxiao MO Xunjie LIANG Xiaoting MA College of Clinical Medicine Youjiang Medical University for Nationalities College of Pharmacy Youjiang Medical University for Nationalities Key Laboratory of Guangxi Universities on National Medicine in Youjiang River Basin

[Objectives] To compare different extraction methods for total alkaloids from Abrus cantoniensis Hance taking chloroform as solvent. [Methods] The ethanol extraction method,ultrasonic extraction method,acid water extraction method,and Soxhlet extraction method were used to extract total alkaloids,and the total alkaloids of Abrus cantoniensis Hance were measured at 238 nm wavelength. [Results] The extraction rate of ethanol extraction method was 14. 76 mg/100 g; the extraction rate of ultrasonic extraction method was 56. 85 mg/100 g; the extraction rate of acid water extraction method was 56. 63 mg/100 g; the extraction rate of Soxhlet extraction method was 58. 19 mg/100 g.[Conclusions]Results indicate that Soxhlet extraction method can obtain the highest extraction rate.

关键词： Total alkaloids Abrus cantoniensis Hance Extraction methods Comparison

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