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Rational Daily Administration Times of canhuang tablet Based on PD/PK Model in Rats with Jaundice

Rational Daily Administration Times of Canhuang Tablet Based...

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第十四届全国中药和天然药物学术研讨会

作者： Jinxia Bai Jin Han Hongge Chen Baode Shen He Xu Ling Dai Chengying Shen Hailong Yuan 302 Hospital of PLA

Objective To study the rational daily administration times of canhuang tablet(CHT) for treating jaundice in rats based on pharmacodynamics/ pharmacokinetics model.Methods Rats were mbdeled by orally administrating 4%1-Naphthylisothiocyanate(75mg/kg).After48 h,CHT was orally administrated with a dose of 0.75g/kg once a day,0.375 g/kg twice a day and 0.25 g/kg three times a day,respectively.Blood was collected from the orbital sinus at different intervals,then we investigated the levels of liver enzymes and bilirubins using these processed blood sample.Bile was collected and determined after first administration,and HPLC were used to determine the concentration of berberine in the bile at the same time.Finally,we obtained the time-effect curve and time-dose curve.Results Compared with the groups of rats taking CHT twice and thrice a day,the total bile within 10 h of the rats taking CHT once a day were 1.32 and 1.47 times higher,respectively.The results also showed that there was good consistency between pharmacokinetics of berberine and the pharmacodynamics of the effect on liver enzymes and bilirubins in vivo.AUC of berberine and the cholaneresis and retro-jaundice kinectics when administrated once a day were significantly higher than that of administrated 2 and 3 times a day.Conclusions It is reasonable to take CHT one time a day in the treatment of experimental jaundice,which may provide a reference for clinical application of CHT.

关键词： daily administration times canhuang tablet berberine Bile pharmacokinetics jaundice

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