Rational Daily Administration Times of Canhuang Tablet Based on PD/PK Model in Rats with Jaundice
作者单位：302 Hospital of PLA
会议名称：《第十四届全国中药和天然药物学术研讨会》
会议日期：2014年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
关 键 词：daily administration times Canhuang Tablet berberine Bile pharmacokinetics jaundice
摘 要：Objective To study the rational daily administration times of Canhuang Tablet(CHT) for treating jaundice in rats based on pharmacodynamics/ pharmacokinetics *** Rats were mbdeled by orally administrating 4%1-Naphthylisothiocyanate(75mg/kg).After48 h,CHT was orally administrated with a dose of 0.75g/kg once a day,0.375 g/kg twice a day and 0.25 g/kg three times a day,*** was collected from the orbital sinus at different intervals,then we investigated the levels of liver enzymes and bilirubins using these processed blood *** was collected and determined after first administration,and HPLC were used to determine the concentration of berberine in the bile at the same ***,we obtained the time-effect curve and time-dose *** Compared with the groups of rats taking CHT twice and thrice a day,the total bile within 10 h of the rats taking CHT once a day were 1.32 and 1.47 times higher,*** results also showed that there was good consistency between pharmacokinetics of berberine and the pharmacodynamics of the effect on liver enzymes and bilirubins in *** of berberine and the cholaneresis and retro-jaundice kinectics when administrated once a day were significantly higher than that of administrated 2 and 3 times a *** It is reasonable to take CHT one time a day in the treatment of experimental jaundice,which may provide a reference for clinical application of CHT.