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A Large Acute Gastroenteritis Outbreak Associated with Both campylobacter coli and Human Sapovirus—Beijing Municipality,China,2021

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China CDC weekly 2023年第52期5卷 1167-1173页

作者： Lin Zou Ying Li Guilan Zhou Zhenzhou Huang Changyan Ju Chunyan Zhao Xiang Gao Bojun Zhen Ping Zhang Xiaochen Guo Jing Zhang Yang Zhang Bo Liu Shaolei Zhou Aixia Yan Ying Kang Yanchun Wang Hongmei Ma Xiaohui Li Maojun Zhang Tongzhou District Center for Disease Control and Prevention BeijingChina Shunyi District Center for Disease Control and Prevention BeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Nanshan District Center for Disease Control and Prevention Shenzhen CityGuangdong ProvinceChina

What is already known about this topic?campylobacter is a significant foodborne pathogen that leads to global outbreaks of acute gastroenteritis(AGE)usually affecting less than 30 individuals.Human sapovirus(HuSaV)is an enteric virus responsible for sporadic cases and outbreaks of AGE worldwide.In a study conducted in Beijing,HuSaV detection ranked second after norovirus.What is added by this report?We present a discussion of the first large-scale outbreak of AGE caused by both campylobacter coli(C.coli)and HuSaV.The outbreak involved a total of 996 patients and exhibited two distinct peaks over a period of 17 days.Through case-control studies,we identified exposure to raw water from a secondary water supply system as a significant risk factor.Among 83 patients,49 samples tested positive for C.coli,39 samples tested positive for HuSaV,and 27 samples tested positive for both pathogens using real-time polymerase chain reaction detection.Furthermore,whole-genome sequencing of 17 C.coli isolates obtained from 17 patients revealed that all isolates belonged to a highly clonal strain of C.coli.What are the implications for public health practice?Outbreaks of AGE resulting from multiple pathogen infections warrant increased attention.This report emphasizes the significance of ensuring the safety of drinking water,particularly in secondary supply systems.

关键词： campylobacter Human enteritis

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campylobacter enteritis in adult patients with acute diarrhea from 2005 to 2009 in Beijing, China

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Chinese Medical Journal 2011年第10期124卷 1508-1512页

作者： CHEN Jie SUN Xin-ting ZENG Zheng YU Yan-yan Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

Background There has been a marked global increase in the incidence of human campylobacter enteritis in recent years. This study investigated the epidemiological and clinical features of campylobacter enteritis in adult patients suffering from acute diarrhea.Methods This was a retrospective review of campylobacter enteritis in adult patients with acute diarrhea presenting at Beijing University First Hospital, Beijing, China, in the summer and autumn （April to October） of 2005 to 2009. The data collected included the species of campylobacter identified, and the age, gender, clinical manifestations and results of laboratory test on stool samples collected from the patients. campylobacter sensitivity tests to various antimicrobial agents were conducted on 80 specimens. Chi-square tests were applied using SPSS13.0 software and a two-sided P value of 〈0.05 was considered statistically significant.Results campylobacter spp. isolated from the stool specimens of 142 patients with diarrhea represented 14.9% of all the cases examined. C. jejuni was identified in 127 patients （89.4%） and C. coli in 15 others （10.6%）. The infection incidence was highest in the age range of 21-30 years which comprised 21.7% of the total cases examined. Most cases of diarrhea （46 patients） occurred in June. Watery diarrhea （97.2%）, abdominal pain （72.5%） and fever （64.8%） were the most common manifestations of enteric campylobacteriosis. Only four patients （2.8%） had bloody diarrhea. The antimicrobial resistance rates were： cefoperazone （100%）, levofloxacin （61.3%）, gentamicin （12.5%）, erythromycin （6.3%）, and azithromycin （2.5%）.Conclusions campylobacter was prevalent among adults with acute diarrhea from 2005 to 2009 in Beijing, China. The large number of those afflicted by the disease warrants the commission of a large multicenter study to determine the extent of enteric campylobacteriosis in this region

关键词： campylobacter enteritis drug resistance signs and symptoms

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campylobacter jejuni enterocolitis presenting with testicular pain: A case report

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World Journal of Clinical Cases 2020年第15期8卷 3280-3283页

作者： Masahiro Sanagawa Tsuneaki Kenzaka Sayaka Kato Ichiko Yamaoka Shouichi Fujimoto Department of Internal Medicine Miyazaki Seikyo HospitalMiyazaki 880-0824Japan Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterHyogo 669-3495Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineHyogo 652-0032Japan Department of General Surgery Miyazaki Seikyo HospitalMiyazaki 880-0824Japan Department of Hemovascular Medicine and Artificial Organs Faculty of MedicineUniversity of MiyazakiMiyazaki 889-1692Japan

BACKGROUND Common symptoms of campylobacter colitis include abdominal pain,vomiting,diarrhea,and fever,among others.However,campylobacter colitis also has a high incidence of extraintestinal symptoms.CASE SUMMARY We report the case of a 51-year-old man who presented with bilateral testicular pain.A scrotal examination failed to reveal any physical findings,but the patient exhibited mild tenderness in the right lower abdomen.Computed tomography revealed ileocecal wall thickening.Post-admission,the patient developed diarrhea,and a stool culture was submitted;campylobacter jejuni infection was confirmed.Testicular pain is known to be caused by appendicitis.Consequently,we suggest that campylobacter colitis,which causes ileocecal inflammation,caused the testicular pain in this case.CONCLUSION In patients with testicular pain and no other objective findings,diseases such as campylobacter colitis should be considered.

关键词： campylobacter Colitis Testicular pain Ileocecal inflammation Related pain Case report

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Gastroenteritis Outbreak Caused by campylobacter jejuni — Beijing, China, August, 2019

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China CDC weekly 2020年第23期2卷 422-425页

作者： Ying Li Guilan Zhou Peng Gao Yixin Gu Hairui Wang Shuang Zhang Yanchun Zhang Yuanyuan Wang Hongbo Jing Chao He Guoxin Zhen Hongmei Ma Yindong Li Jianzhong Zhang Maojun Zhang Shunyi District Center for Disease Control and Prevention BeijingChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention

Summary What is already known about this topic?campylobacter genus bacteria are recognized as some of the leading causes of the bacterial diarrheal illness in both developing and developed countries.Recent pilot surveillance study revealed campylobacter is the most common pathogen in the diarrheal cases using the enhanced filtration methods in Beijing.One outbreak caused by multi-drug resistant campylobacter coli(C.coli)was identified in 2018.

关键词： campylobacter diarrhea break

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Reaction of antibodies to campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens

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World Journal of Gastroenterology 2019年第9期25卷 1050-1066页

作者： Aristo Vojdani Elroy Vojdani Immunosciences Lab. Inc. Los Angeles Cyrex Labs LLC. Phoenix Department of Preventive Medicine Loma Linda University School of Medicine Regenera Medical Los Angeles

BACKGROUND The bacteria campylobacter jejuni(C. jejuni) is commonly associated with GuillaneBarré syndrome(GBS) and irritable bowel syndrome(IBS), but studies have also linked it with Miller Fisher syndrome, reactive arthritis and other disorders, some of which are autoimmune. It is possible that C. jejuni and its toxins may be crossreactive with some human tissues and food antigens, potentially leading to autoimmune responses.AIM To measure the immune reactivity of C. jejuni and C. jejuni cytolethal distending toxin(Cdt) antibodies with tissue and food antigens to examine their role in autoimmunities.METHODS Using enzyme-linked immunosorbent assay(ELISA) methodology, specific antibodies made against C. jejuni and C. jejuni Cdt were applied to a variety of microwell plates coated with 45 tissues and 180 food antigens. The resulting immunoreactivities were compared to reactions with control wells coated with human serum albumin(HSA) which were used as negative controls and with wells coated with C. jejuni lysate or C. jejuni Cdt which served as positive controls.RESULTS At 3 SD above the mean of control wells coated with HSA or 0.41 OD, the mouse monoclonal antibody made against C. jejuni showed moderate to high reactions with zonulin, somatotropin, acetylcholine receptor, β-amyloid and presenilin.This immune reaction was low with an additional 25 tissue antigens including asialoganglioside, and the same antibody did not react at all with another 15 tissue antigens. Examining the reaction between C. jejuni antibody and 180 food antigens, we found insignificant reactions with 163 foods but low to high immune reactions with 17 food antigens. Similarly, we examined the reaction of C. jejuni Cdt with the same tissues and food antigens. The strongest reactions were observed with zonulin, intrinsic factor and somatotropin. The reaction was moderate with 9 different tissue antigens including thyroid peroxidase, and reaction was low with another 10 different antigens, including neuronal antigens.The reaction of C. jejuni

关键词： campylobacter jejuni Cytolethal distending toxin Tissue antigens Food antigens Autoimmune reactivities Cross-reactivity

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Antibiotic susceptibility profiling and virulence potential of campylobacter jejuni isolates from different sources in Pakistan

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Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 197-202页

作者： Fariha Masood Siddiqui Muhammad Akram Nighat Nourccn Zobia Noreen Habib Bokhari Department of Biosciences.COMSATS Institute of Information Technology

Objective:To determine antibiotic resistance patterns and virulence potential of campylobacter jejuni(C.jejuni) isolates from clinical human diarrheal infections,cattle and healthy broilers.Methods:Antibiotic sensitivity patterns of C.jejuni isolates were determined by Kirby Bauer Disc Diffusion assay.These isolates were then subjected to virulence profiling for the detection of map A(membrane-associated protein).cadF(fibronectin binding protein).wlaN(beta-1.3-galaclosyltransferase) and neu AB(sialic acid biosynthesis gene).Further C.jejuni isolates were grouped by random amplification of polymorphic DNA(RAPD) profiling.Results:A total of436 samples from poultry(n=88).cattle(n=216) and humans(n=132) from different locations were collected.Results revealed percentage of C.jejuni isolates were 35.2%(31/88).25.0%(54/216) and 11.3%(15/132) among poultry,cattle and clinical human samples respectively.Antibiotic susceptibility results showed that similar resistance patterns to cephalothin was ie.87.0%,87.1%and 89%among humans,poultry and cattle respectively,followed by sulfamethoxazolc+trimcthoprim 40.0%,38.7%and 31.0%in humans,poultry and cattle and Ampicillin 40%,32%and 20%in humans,poultry and cattle respectively.Beta-lactamase activity was detected in 40.00%humans.20.37%cattle and 32.25%in poultry C.jejuni isolates.CadF and mapA were present in all poultry,cattle and human C jejuni isolates.wlauN was not detected in any isolate and neu AB was found in 9/31(36%) poultry isolates.RAPD profiling results suggested high diversity of C.jejuni isolates.Conclusions:Detection of multidrug resistant C.jejuni strains from poultry and cattle is alarming as they can be potential hazard to humans.Moreover,predominant association of virulence factors,cadF and map A(100%each) in C.jejuni isolates from all sources and neuAB(36%) with poultry isolates suggest the potential source of transmission of diverse types of C.jejuni to humans.

关键词： campylobacter jejuni Antibiotic susceptibility Virulence genes PCR RAPD

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Presence and Antimicrobial Susceptibility of RE-cmeABC-Positive campylobacter Isolated from Food-Producing Animals, 2014–2016

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Engineering 2020年第1期6卷 34-39页

作者： Dejun Liu Weiwen Liu Xing Li Hong Yao Zhangqi Shen Yang Wang Jianzhong Shen Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China

campylobacter spp. are the leading cause of human gastroenteritis worldwide. RE-CmeABC is a newly identified resistance-enhancing multidrug efflux pump of campylobacter spp. (C. spp.) that confers high-level resistance to fluoroquinolones, phenicols, macrolides, and tetracyclines (TETs), all of which are critical drugs in both human and veterinary medicine. In this study, we analyzed the presence and antimicrobial susceptibility of RE-cmeABC-positive campylobacter isolates of food-animal origin from three representative regions (Shandong, Shanghai, and Guangdong) in China over three successive years, from 2014 to 2016. A total of 1088 campylobacter isolates (931 C. coli and 157 C. jejuni) were recovered from the RE-cmeABC screening. We detected 122 (11.2%) RE-cmeABC-positive isolates of chicken origin, including 111 (70.7%) C. jejuni and 11 (1.2%) C. coli. This multidrug efflux pump is more prevalent among C. jejuni than C. coli. The level of resistance was significantly different in 111 RE-cmeABC-positive C. jejuni versus 46 RE-cmeABC-negative C. jejuni for florfenicol, clindamycin, and erythromycin (P campylobacter of food-animal origin, which would pose a significant threat to public health.

关键词： RE-cmeABC campylobacter Ciprofloxacin Florfenicol

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Molecular detection of virulence genes in campylobacter species isolated from livestock production systems in South Africa

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Journal of Integrative Agriculture 2020年第6期19卷 1656-1670页

作者： Bongekile NGOBESE Oliver Tendayi ZISHIRI Mohamed Ezzat EL ZOWALATY Discipline of Genetics School of Life SciencesUniversity of KwaZulu-NatalDurban 4000South Africa Zoonosis Science Center Department of Medical Biochemistry and MicrobiologyUppsala UniversityUppsala SE-75185Sweden Infectious Diseases and Anti-Infective Therapy Research Group College of Pharmacy and Sharjah Medical Research InstituteUniversity of SharjahSharjah 27272UAE

campylobacter species are a major cause of foodborne bacterial infections in both developed and developing countries worldwide.campylobacter jejuni is responsible for the majority of infectio ns.This study was con ducted to identify virule nceassociated genes in campylobacter species isolated from livestock production systems in South Africa.A total of 250 fecal samples consisting of cattle(n=50),chickens(n=50),goats(n=50),sheep(n=50)and pigs(n=50)were randomly collected from livestock in Eastern Cape and KwaZulu-Natal provinces of South Africa between April and October 2018.The samples were an a lyzed for the presence of virule nee genes in campylobacter species using molecular PCR-based methods.It was found that 77 and 23%of campylobacter jejuni and campylobacter coli respectively were isolated from all the livestock samples.There were positive significant(Pcampylobacter.The high prevale nee of virule nee genes highlights the sign ifica nee of campylobacter\r\livestock production systems in South Africa.This requires the implementation of one-health approaches to reduce the impact of foodborne and zoonotic diseases for the welfare of human and animal health.

关键词： campylobacter zoonotic cytotoxicity pathogenicity virulenee campylobacteriosis foodbome livestock PCR one-health

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Prevalence and fuoroquinolone resistance of campylobacter spp.isolated from beef cattle in Japan

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Animal Diseases 2022年第3期2卷 181-186页

作者： Yoshimasa Sasaki Hiroshi Asakura Tetsuo Asai Division of Biomedical Food Research National Institute of Health Sciences3‑25‑26TonomachiKawasaki‑kuKawasakiKanagawa 210‑9501Japan The United Graduate School of Veterinary Science Gifu University1‑1YanagidoGifu 501‑1193Japan

Beef is a source of human campylobacter infections.Antimicrobial treatment is needed when patients are immuno‑compromised or have other comorbidities.Therefore,we investigated the prevalence and antimicrobial resistance of campylobacter spp.in beef cattle in Japan.Rectal swab samples were collected from 164 beef cattle at an abattoir between March 2021 and August 2021,and campylobacter spp.were isolated from 94(57.3%)cattle.C.jejuni and C.coli were isolated from 68 and 26 cattle,respectively.For campylobacter jejuni,the resistant rates against ampicillin,tetracycline and ciprofoxacin were 20.6,75.0 and 64.7%,respectively.For C.coli,the resistant rates against ampicil‑lin,tetracycline and ciprofoxacin were 53.8,76.9 and 88.5%,respectively.No campylobacter isolates were resistant to erythromycin.By multilocus sequence typing,C.jejuni and C.coli isolates were classifed into 22 and 2 sequence types(STs).The top three STs of C.jejuni were ST806(12 isolates),ST21(nine isolates),and ST459(eight isolates).The most frequent ST of C.coli was ST1068(23 isolates).The results suggest that campylobacter spp.are prevalent in the gastrointestinal tract of beef cattle slaughtered at abattoirs.Furthermore,the administration of erythromycin is efec‑tive against human campylobacteriosis caused by beef consumption.Monitoring the prevalence and antimicrobial resistance of campylobacter spp.in beef cattle could be useful for managing the risk of human campylobacteriosis.

关键词： Antimicrobial resistance Beef cattle campylobacter Fluoroquinolone resistance Multilocus sequence typing

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Antibiotic resistance profile and RAPD analysis of campylobacter jejuni isolated from vegetables farms and retail markets

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Asian Pacific Journal of Tropical Biomedicine 2016年第1期6卷 71-75页

作者： John Yew Huat Tang Mohd Ikhsan Khalid Syazana Aimi Che Abdullah Abu-Bakar Son Radu Department of Food Industry Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin Tembila Campus Food Safety Research Centre Faculty of Food Science and Technology Universiti Putra Malaysia

Objective:To investigate antibiotic resistance profile and characterize campylobacter jejuni(C.jejuni) isolates using random amplified polymorphic DNA(RAPD) analysis.Methods:Ninety eight C.jejuni isolates from farms and retail outlets were screened against 10 antibiotics commonly used clinically and agriculturally by using disk diffusion method.RAPD analysis was done to characterize 98 C.jejuni isolates.Results:Fifty-one percent of the isolates had multiple antibiotic resistance index 0.2 and below.This indicated that the isolates in the vegetables were not from the high risk environment or extensive farming practices.C.jejuni isolates found resistant towards penicillin G(93%),vancomycin(86%),ampicillin(35%),erythromycin(28%),gentamycin(4%),amikacin(3%),enrofloxacin(1%),norfloxacin(1%) and no resistance towards ciprofloxacin.RAPD clustering analysis showed that the contamination of C.jejuni in vegetables was likely due to cross contamination at retail markets.Conclusions:C.jejuni contamination in vegetables at retail markets was due to cross contamination.Current finding proved that C.jejuni in small scale vegetables production was less expose towards antibiotic abuse.

关键词： campylobacter jejuni Multiple antibiotic resistance index Antibiotic resistance RAPD analysis

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