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Modulatory effect of caffeic acid in alleviating diabetes and associated complications

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World Journal of Diabetes 2023年第2期14卷 62-75页

作者： Risha Ganguly Shiv Vardan Singh Kritika Jaiswal Ramesh Kumar Abhay K Pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Diabetes mellitus(DM)is one of the most common metabolic disorders characterized by elevated blood glucose levels.Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy,nephropathy,retinopathy,cardiovascular disorders,and diabetic foot ulcers.Excess production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated complications.Natural polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase,heme oxygenase-1,superoxide dismutase,and catalase that are essential in maintaining redox balance,and ameliorate oxidative stress.caffeic acid(CA)is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties including antioxidant,anti-inflammatory,anti-atherosclerotic,immune-stimulatory,cardioprotective,antiproliferative,and hepatoprotective activities.CA acts as a regulatory compound affecting numerous biochemical pathways and multiple targets.These include various transcription factors such as nuclear factor-B,tumor necrosis factor-α,interleukin-6,cyclooxygenase-2,and nuclear factor erythroid 2-related factor 2.Therefore,this review summarizes the pharmacological properties,molecular mechanisms,and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated complications.The bioavailability,drug delivery,and clinical trials of CA have also been discussed.

关键词： Diabetes mellitus caffeic acid Diabetic foot ulcer Retinopathy Nephropathy

caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

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Acta Pharmacologica Sinica 2006年第9期27卷 1103-1110页

作者： Yu ZHOU San-hua FANG Yi-lu YE Li-sheng CHU Wei-ping ZHANG Meng-ling WANG Er-qing WEI~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou China

Aim:To investigate the effects of caffeic acid on early and delayed injuries afterfocal cerebral ischemia in rats,and the possible relation to 5-lipoxygenaseinhibition.Methods:Transient focal cerebral ischernia was induced by middlecerebral artery occlusion in Sprague-Dawley rats.caffeic acid(10 and 50 mg/kg)was ip injected for 5 d after ischemia.The brain injuries were observed,and thelevels of cysteinyl leukotrienes and leukotriene B4in the brain tissue weremeasured.Results:caffeic acid(50 mg/kg)ameliorated neurological dysfunctionand neuron loss,and decreased infarct volume 24 h after ischemia;it attenuatedbrain atrophy,infarct volume,and particularly astrocyte proliferation 14 d afterischemia.In addition,it reduced the production of leukotrienes(5-lipoxygenasemetabolites)in the ischemic hemispheres 3 h and 7 d after ischemia.Conclusion:caffeic acid has protective effect on both early and delayed injuries after focalcerebral ischemia in rats;and this effect may partly relate to 5-lipoxygenaseinhibition.

关键词： caffeic acid focal cerebral ischemia neuron astrocyte 5-lipoxygenase leukotriene

caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 244-253页

作者： Venugopal R.Bovilla Preethi G.Anantharaju Sireesh Dornadula Prashanthkumar M.Veeresh Mahadevaswamy G.Kuruburu Vidya G.Bettada Kunka Mohanram Ramkumar SubbaRao V.Madhunapantula Center of Excellence in Molecular Biology and Regenerative Medicine Department of BiochemistryJSS Medical CollegeJSS Academy of Higher Education&ResearchMysore-570015KarnatakaIndia SRM Research Institute Department of BiotechnologySchool of BioengineeringSRM Institute of Science and TechnologyKattankulathur-603203Tamil NaduIndia

Objective:To assess the nuclear factor-erythroid 2-related factor-2(Nrf2)modulatory effect of caffeic acid and protocatechuic acid and determine the anti-tumor activity of these phenolic compounds against Ehrlich ascites carcinoma growth in mice.Methods:Antioxidant activity of protocatechuic acid and caffeic acid was assessed using ferric reducing antioxidant power(FRAP)and 2,2-diphenyl-1-picrylhydrazyl(DPPH).Nrf2 activation potential of phenolic compounds was tested by quantitative realtime polymerase chain reaction,and luciferase complementation reporter assays.In vivo efficacy was tested using the Ehrlich ascites carcinoma model.Results:FRAP and DPPH radical scavenging assays showed that caffeic acid and protocatechuic acid were more potent compared with cinnamic acid and benzoic acid.Luciferase complementation reporter assays identified caffeic acid and protocatechuic acid as the activators of Nrf2.Both caffeic acid and protocatechuic acid upregulated the expression of Nrf2 target genes heme oxygenase-1(HO-1),glutamate-cysteine ligase catalytic subunit(GCLC),and glutamate-cysteine ligase modifier subunit(GCLM)and the activity of NAD(P)H:quinone oxidoreductase 1(NQO1)when tested on HCT-116 cells using a cell-based assay system at 9 h.In addition,intraperitoneal administration of caffeic acid and protocatechuic acid to Ehrlich ascites carcinoma bearing mice suppressed tumor growth and angiogenesis.Conclusions:caffeic acid and protocatechuic acid can modulate Nrf2 and inhibit Ehrlich ascites carcinoma cells.

关键词： Ehrlich ascites carcinomas Nrf2 Protocatechuic acid caffeic acid NQO1 activity

Evaluation on monoamine neurotransmitters changes in depression rats given with sertraline, meloxicam or/and caffeic acid

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Genes & Diseases 2019年第2期6卷 167-175页

作者： Dan Huang Lu Zhang Jun-qing Yang Ying Luo Ting Cui Ting-ting Du Xin-hui Jiang School of Pharmacy Chongqing Medical UniversityChongqing400016China West China-Washington Mitochondria and Metabolism Center West China Hospital/West China Medical SchoolSichuan UniversityChengdu 610041China Zunyi Medical and Pharmaceutical College Zunyi563006China

Inflammation drives the development of depression and may affect neurotransmitters and thus neurocircuits increase the risk of depression.To investigate the influence of inhibition of inflammatory pathways on the biogenic amine neurotransmitters metabolism in depressive rats,sertraline,and meloxicam,the inhibitors of arachidonic acid-cyclooxygenase-2/lipoxygenase(AA-COX-2/5-LO)pathways,were given to depressive rats.After the development of depression model by chronic unpredictable mild stress(CUMS)for 6 weeks,Successful modeling rats were selected and randomly divided into CUMS group and medication administration group.After given medicine,The biogenic amine neurotransmitters in rat cortex and hippocampus were measured by high-performance liquid chromatography equipped with an electrochemical detector(HPLC-ECD).Compared with the normal group,the concentration of norepinephrine(NE)significantly decreased and the concentrations of Tyrosine(Tyr),Tryptophan(Trp),3,4-dihydroxyphenyl acetic acid(DOPAC),3-methoxy-4-hydroxyphenylglycol(MHPG),homovanillic acid(HVA)and 5-hydroxyindoleacetic acid(5-HIAA)significantly increased in the CUMS group.Sertraline significantly inhibited the elevation of 5-HIAA.Meloxicam inhibited the decrease of NE level in CUMS-induced rat and the increase of Trp,MHPG,and 5-HIAA level in a dose-dependent manner.caffeic acid inhibited the decrease of NE and the increase of Trp and MHPG in a dose-dependent manner.The inhibition of AA-COX-2/5-LO pathways can improve the behaviors of depression rats and suppress CUMSinduced changes in biogenic amines.Compared with the single-dose lipoxygenase(5-LO)or Cyclooxygenase-2(COX-2)inhibitor,the combination treatment with meloxicam 1 mg/kg and caffeic acid 10 mg/kg have no significant improvement in CUMS-induced depression behavior and the level of cortical monoamine neurotransmitters and their metabolites.

关键词： AA-COX-2/5-LO inflammatory pathways Bioamine neurotransmitters caffeic acid Depression rat Meloxicam Sertraline

A facile electrochemical synthesis of caffeic acid derivatives in the presence of acetylacetone or methyl acetoacetate in aqueous medium

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Chinese Chemical Letters 2007年第2期18卷 130-132页

作者： Cheng Chu Zeng[a]&Email:zengcc@*** Li Ming Hu[a] Jia Zeng[a] Ru Gang Zhong[a] [a]College of Life Science & Bioengineering Beijing University of Technology Beijing 100022 China

The anodic oxidation of caffeic acid in the presence of acetylacetone or methyl acetoacetate in aqueous solution has been studied by cyclic voltammetry and controlled-potential electrolysis techniques. The result showed that caffeic acid was oxidized to the corresponding o -benzoquinone, which underwent further Michael-addition with acetylacetone or methyl acetoacetate to produce caffeic acid derivative 3,4-dihydroxy-6-(1-acetylacetone)-yl cinnamic acid 4a or 3,4-dihydroxy-6-(1-acetyl-methylacetate)-yl cinnamic acid 4b .

关键词： caffeic acid Electrochemical synthesis Acetylacetone Methyl acetoacetate

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Effect of caffeic acid on the Tumor Cells U937 Evaluated by an Electrochemical Voltammetric Method

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Chinese Chemical Letters 1999年第9期10卷 781-782页

作者： Hong Yan JIAN Cheng Cat AN Jun FENG Yun Xiang CI Yi Li Ayako SUGISAWA Maremitsu IZUMITANI Zhang Liang CHEN (1NLPGE.College of Life Sciences. Peking University, Beijing 1008712Departmcnt of Chemistry,Peking University,Beijing 1008713Laborutory of F NLPGE College of Life Sciences Peking University Beijing 100871 China Department of Chemistry Peking University Beijing 100871 China Laboratory of Food and Nutrition Kyoritsu Women's University Tokyo 101-0003 Japan

Electrochemical voltammetric method can;be used to monitor cell health state during its growth. Here we studied the effect of caffeic acid on leukemia cells U937 by the voltammetric behavior of the cells. The result showed that this drug had a negative influence on cell health. which suggests that caffeic acid may be used in inhibition of tumor cells.

关键词： voltammetric behavior U937 cells caffeic acid

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Extraction Process and Content Determination of caffeic acid in Laggera alata from Different Production Areas of Guangxi

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Medicinal Plant 2018年第4期9卷 73-76页

作者： Jiangcun WEI Yong CHEN Zujie QIN Jiabao MA Shengbin CHEN Zuliang QUE Jinzhou LI Zijun CHEN Guangxi Zhuang International Hospital Guangxi University of Chinese Medicine The First Affiliated Hospital of Guangxi University of Chinese Medicine

[Objectives] To establish a method for determining the content of Laggera alata( D. Don) Sch. Bip. Ex Oliv. using caffeic acid the target component,and to compare the content of caffeic acid in the medicinal materials of L. alata in different production areas of Guangxi.[Methods]The content was determined by Inertsil~ODS-3 chromatographic column C_(18)( 4. 60 mm × 250 mm,5 μm,mobile phase: acetonitrile-0. 1% phosphoric acid( 22∶ 78),detection wavelength: 320 nm,flow rate: 1. 0 m L/min,column temperature: 30℃,and injection volume: 10 μL. [Results] The caffeic acid showed a good linear relationship in the range of injection volume of 0. 025 92-0. 259 2 μg( R =0. 999 5). The average recovery rate was 98. 33%( RSD = 1. 85%). L. alata in different production areas of Guangxi contained the caffeic acid,and there was a great difference in the caffeic acid. L. alata in Baise had the highest content of caffeic acid,while that in Guilin had the lowest content of caffeic acid. [Conclusions]This method can accurately determine the content of caffeic acid and is expected provide a scientific basis for the development and utilization of herbal medicine L. alata.

关键词： Laggera alata(D.Don) Sch.Bip.Ex Oliv. HPLC caffeic acid Extraction process Content Determination

Purification of caffeic acid from hawthorn using molecular imprinting polymers with deep eutectic solvents

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Purification of caffeic acid from hawthorn using molecular i...

Difference analysis of different parts of chicory based on HPLC fingerprint and multi-component content determination

第二十届全国色谱学术报告会及仪器展览会

作者： Qian Wang Guizhen Li Tao Zhu Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical Engineering Tianjin University of Technology

＜正＞Molecularly impr inted polymers（MIPs）with caffeic acid as template and non-imprinted polymers（NIPs）materials were prepared in an in an identical procedure.Field emission scanning electron microscopy（FE-SEM... 详细信息

关键词： solid-phase extraction imprinted polymers deep eutectic solvents caffeic acid

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Chinese Herbal Medicines 2022年第2期14卷 317-323页

作者： Mengzhen Yan Zhenling Zhang Yanze Liu School of Pharmacy Henan University of Traditional Chinese MedicineZhengzhou 450046China Henan Research Center for Special Processing Technology of Chinese Medicine Zhengzhou 450046China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Ministry of Education Henan University of Chinese MedicineZhengzhou 450046China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Objective:To establish HPLC fingerprints of different parts of chicory stems,leaves,roots,flowers and seeds,and compare the similarities and differences of chemical components in different parts,so as to provide a scientific basis for the comprehensive utilization of chicory.Methods:To establish the HPLC fingerprint of chicory,the chromatographic column was chosen with Agilent ZORBAX Eclipse XDB-C_(18),the mobile phase was methanol(A)-0.2%formic acid(B),the flow rate was 1 mL/min,the column temperature was 30℃,and the detection wavelength was 254 nm.The Similarity Evaluation System of Chromatographic Fingerprint of Traditional Chinese Medicine(2012 Edition)was used to evaluate the similarity of different parts of decoction pieces,and the determination method of multi-component content was established based on fingerprint identification chromatographic peaks,and the determination results were analyzed.Results:The HPLC fingerprinting method of chicory was established.Sixteen chromatographic peaks were identified and 10 of them were identified as:caftaric acid(1),esculin(2),chlorogenic acid(3),esculetin(4),caffeic acid(5),cichoric acid(8),hyperoside(11),rutin(12),isochlorogenic acid C(14)and luteolin(16).The similarity of different parts was 0.084–0.701.At the same time,the total content of detected chemical components was ranked as flower>leaf>stem>root>seed.Roots did not contain caftaric acid,rutin,and luteolin,flowers did not contain luteolin,and seeds did not contain caftaric acid,cichoric acid,and luteolin.The content of cichoric acid in leaves was the most,and esculin in flowers was the most.Conclusion:The results of HPLC fingerprint and multi-component content determination revealed the similarity and difference of different parts of chicory from chemical composition,indicating that there were certain differences in different parts of chicory.The established HPLC fingerprinting method can provide a reference for quality control and evaluation of different parts of the chicory.

关键词： caffeic acid cichoric acid chicory chlorogenic acid esculetin fingerprint HPLC hyperoside isochlorogenic acid C luteolin multi-component content determination rutin

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