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Antidiabetic effect of chrysophyllum albidum is mediated by enzyme inhibition and enhancement of glucose uptake via 3T3-L1 adipocytes and c2c12 myotubes

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 387-396页

作者： Benjamin Kingsley Harley Rita Akosua Dickson Isaac Kingsley Amponsah Robert A Ngala Dorice Berkoh Theophilus christian Fleischer Department of Pharmacognosy and Herbal Medicine School of PharmacyUniversity of Health and Allied SciencesHoGhana Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Molecular Medicine School of Medical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Basic and Applied Biology School of SciencesUniversity of Energy and Natural ResourcesSunyaniGhana

Objective:To investigate the in vivo and in vitro antidiabetic potential of chrysophyllum ***:The effects of oral treatment with hydro-ethanolic extract(125,250 and 500 mg/kg)of the stem bark of chrysophyllum albidum and glibenclamide for 21 d on glucose level,serum enzyme markers for liver function,lipid profile,total protein,serum urea,serum creatinine,and body weight were evaluated in experimental diabetic rats administered with 45 mg/kg of *** vitro assays including glucose uptake in c2 c12 cells and 3 T3-L1 adipose tissues,α-glucosidase andα-amylase inhibition were employed to evaluate the possible mechanism of hypoglycemic action of the *** and nitric oxide radical antioxidant activity of the extract was also ***:The increased levels of blood glucose,triglycerides,lowdensity lipoprotein,total cholesterol,serum aspartate,and alanine transaminases,creatinine,and urea in the diabetic animals were reduced significantly(Pchrysophyllum albidum *** decreased total protein and high-density lipoprotein concentrations were normalized after *** addition,the extract significantly(Pcreased the transport of glucose in 3 T3-L1 cells and c2 c12 myotubes and exhibited considerable potential to inhibitα-amylase andα-*** also demonstrated potent antioxidant action by scavenging considerably DPPH and nitric oxide ***:chrysophyllum albidum stem bark extract exhibits considerable antidiabetic effect by stimulating glucose uptake and utilization in c2 c12 myotubes and 3 T3-L1 adipocytes as well as inhibiting the activities ofα-amylase andα-glucosidase.

关键词： Antidiabetic c2c12 myotubes α-glucosidase inhibition α-amylase inhibition Glucose uptake chrysophyllum albidum

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Low Intensity Laser Irradiation Improve the Mitochondrial Dysfunction of c2c12 Induced by Electrical Stimulation

Low Intensity Laser Irradiation Improve the Mitochondrial Dy...

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广东省体育科学学会第二届体育科学大会

作者：徐晓阳华南师范大学体育科学学院

We investigated the effects of ES and LIL on the mitochondrial function of cultured c2c12 myotubes in order to find the dosage which can be used to improve the function of mitochondria and then rehabilitate exercise-induced fatigue or *** c2c12 myotubes were subjected to ES or/and LIL irradiation at various *** was detec- ted with DcFH fluorescent probe and mitochondrial function was assessed with *** results showed that ES at 20ms、5Hz and 45V intensity for 75 min can induce mitochon- drial dysfunction of cultured c2c12 ***-induced mitochondrial dysfunction were improved and degenerated by LIL at 0.33～8.22J/cm and 11.22～14.16J/cm,re- *** improvement was significantly higher with LIL at 0.33 and 1.34J/cm, *** conclude that treatment of the cells with proper dosage of LIL irradiation significantly diminished ROS production and rehabilitate mitochondrial function which may provides a foundation for PBM on exercise,induced mitochondrial dysfunction or skeletal muscular fatigue.

关键词： c2c12 myotubes electrical stimulation low intensity laser reactive oxygen species mitochondrial function

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