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Association of Ureaplasma urealyticum Colonization with Development of bronchopulmonary dysplasia: A Systemic Review and Meta-analysis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第2期34卷 265-269页

作者：郑晓丹李聃杨德华向旋梅红普佳睿童强松郑丽端 Department of Stomatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Pediatric Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Pathology Union Hospital Tongji Medical College Huazhong University of Science and Technology

There is controversy regarding the roles of Ureaplasma urealyticum （U. urealyticum） colo- nization in the development of hronchopulmonary dysplasia （BPD）. This study explored the association between U. urealyticum and bronchopulmonary dysplasia at 36 weeks post-menstrual age （BPD36）. Studies published before December 31, 2013 were searched from Medline, Embase, Ovid, Web of Sci- ence, and Cochrane databases, with the terms ＂Ureaplasma urealyticum＂, ＂chronic lung disease＂, or ＂BPD36＂ used, and English language as a limit. The association between U. urealyticum colonization and BPD36 was analyzed with RevMan 4.2.10 software, using the odds ratio （OR） and relative risk （RR） for dichotomous variables. Out of the enrolled 81 studies, 11 investigated the BPD36 in total 1193 in- fants. Pooled studies showed no association between U. urealyticum colonization and subsequent de- velopment of BPD36, with the OR and RR being 1.03 （95% CI=0.78-1.37; P=-0.84） and 1.01 （95% CI= 0.88-1.16, P=-0.84）, respectively. These findings indicated no association between U. urealyticum colo- nization and the development of BPD36.

关键词： bronchopulmonary dysplasia Ureaplasma urealyticum meta-analysis systemic review

Recent Advances in bronchopulmonary dysplasia Protection and Therapy

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Health 2024年第5期16卷 470-489页

作者： Pingfan Xia Hongyi Li Zhe Xu Yongping Lu Guangyuan Central Hospital Affiliated to North Sichuan Medical College Guangyuan China

For preterm infants, bronchopulmonary dysplasia (BPD) is usually caused by abnormal lung development due to various factors during prenatal and postnatal process. One of the reasons for death and bad prognosis of preterm infants is to have BPD. Up to now, there are no unified strategies or drugs to treat BPD. In clinical, many intervention treatments have been applied to achieve BPD therapy, mainly including preterm protection, protective ventilation strategies, and delivery of corticosteroids, pulmonary vasodilators, and antioxidants. This review summarizes the current advances in BPD protection and treatment, and notes that gut microbiota and mesenchymal stem cells (MSCs) can be the promising strategy for protecting and treating BPD in the future.

关键词： bronchopulmonary dysplasia Preterm Infants Protection and Therapy Mesenchymal Stem Cells Gut Microbiota

Influence of Gut and Lung Microbiota and the Gut-Lung Axis on bronchopulmonary dysplasia

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Journal of Clinical and Nursing Research 2024年第9期8卷 30-35页

作者： Binxiang Xu Yumei Liang Affiliated Hospital of Youjiang Medical University for Nationalities Baise 533000Guangxi ProvinceChina

bronchopulmonary dysplasia(BPD),also known as neonatal chronic lung disease,is a common respiratory disease in preterm *** infants with BPD often exhibit changes in gut and lung *** recent years,with the development of high-throughput sequencing technology,more and more mechanisms of the gut-lung axis have been confirmed,helping to explore new directions for the treatment of BPD using microecological *** paper reviews the roles of gut microbiota,lung microbiota,and the gut-lung axis in the pathogenesis of BPD in preterm infants,providing new research avenues for the prevention and treatment of BPD.

关键词： bronchopulmonary dysplasia Gut-lung axis Gut microbiota Lung microbiota

Neonatal bronchopulmonary dysplasia increases neuron apoptosis in hippocampus through HIF-1α and p53 pathway

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Neonatal bronchopulmonary dysplasia increases neuron apoptos...

Prematurity and the burden of influenza and respiratory syncytial virus disease

2015年泛长三角围产医学学术年会暨浙江省围产医学学术...

作者：殷荣复旦大学附属儿科医院新生儿科

Neonatal bronchopulmonary dysplasia(BPD)may lead to an increased risk for brain *** present study aims to investigate the effects of neonatal BPD on neuron apoptosis in hippocampus and cognitive function and explore the underlying *** results showed that pups of BPD model had more apoptosis cells in the hippocampus and longer escape latency in the Morris maze *** Caspase dependent and Caspase nondependent signal pathways were *** examinations showed an elevated p53 level by BPD via HIF-la *** Caspase-3 in the hippocampus was suppressed by both HIF-la and p53 *** findings suggested that neonatal BPD caused impaired cognitive function and neuron apoptosis in hippocampus via p53 and HIF-lα.Although the precise mechanism needs further investigation,this study provided a new evidence of impaired CNS developmental outcomes of BPD.

关键词： bronchopulmonary dysplasia hippocampus neuron apoptosis HIF-1α p53

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World Journal of Pediatrics 2016年第1期12卷 8-18页

作者： Bernhard Resch Stefan Kurath-Koller Monika Eibisberger Werner Zenz Research Unit for Neonatal Infectious Diseases and Epidemiology Division of NeonatologyDepartment of Pediatrics and Adolescent MedicineMedical University of GrazAustria Research Unit for Neonatal Infectious Diseases and Epidemiology Medical University of GrazAustria Research Unit for Infectious Diseases and Vaccinology Division of General PediatricsDepartment of Pediatrics and Adolescent MedicineMedical University of GrazAustria

Background:Respiratory morbidity of former preterm infants and especially those with bronchopulmonary dysplasia(BPD)is high during infancy and early *** sources:We performed a review based on a literature search including EMBASE,MEDLINE,and CINAHL databases to identify all relevant papers published in the English and German literature on influenza and respiratory syncytial virus infection associated with preterm infant,prematurity,and BPD between 1980 and ***:Recurrent respiratory symptoms remain common at preschool age,school age and even into young *** viral respiratory tract infections due to different pathogens cause significant morbidity and necessitate rehospitalizations during the fi rst years of *** uenza virus infection plays a minor role compared to respiratory syncytial virus(RSV)associated respiratory tract infection during infancy and early ***,particular morbidity to both viruses is ***:The particular burden of both viral diseases in preterm infants is dominated by RSV and its associated rehospitalizations during the fi rst two years of *** measures include vaccination against influenza virus of family members and caregivers and active immunization starting at the age of 6 months,and monthly injections of palivizumab during the cold season to avoid severe RSV disease and its sequelae.

关键词： bronchopulmonary dysplasia infl uenza preterm infant respiratory infectious disease respiratory syncytial virus

Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways

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World Journal of Stem Cells 2022年第7期14卷 556-576页

作者： Na Dong Pan-Pan Zhou Dong Li Hua-Su Zhu Ling-Hong Liu Hui-Xian Ma Qing Shi Xiu-Li Ju Department of Pediatrics Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Pediatrics Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Stem Cell and Regenerative Medicine Research Center Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND bronchopulmonary dysplasia(BPD)is not merely a chronic lung disease,but a systemic condition with multiple organs implications predominantly associated with hyperoxia *** advances in current management strategies,limited progress has been made in reducing the BPD-related systemic ***,although the protective effects of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)or their exosomes on hyperoxia-induced lung injury have been explored by many researchers,the underlying mechanism has not been addressed in detail,and few studies have focused on the therapeutic effect on systemic multiple organ *** To investigate whether hUC-MSC intratracheal administration could attenuate hyperoxia-induced lung,heart,and kidney injuries and the underlying regulatory *** Neonatal rats were exposed to hyperoxia(80%O_(2)),treated with hUC-MSCs intratracheal(iT)or intraperitoneal(iP)on postnatal day 7,and harvested on postnatal day *** tissue sections of the lung,heart,and kidney were analyzed *** contents of the bronchoalveolar lavage fluid(BALF),myeloper oxidase(MPO)expression,and malondialdehyde(MDA)levels were *** inflammatory cytokines were measured via enzyme-linked immunosorbent assay.A comparative transcriptomic analysis of differentially expressed genes(DEGs)in lung tissue was conducted via ***,we performed reverse transcription-quantitative polymerase chain reaction and western blot analysis to explore the expression of target mRNA and proteins related to inflammatory and oxidative *** iT hUC-MSCs administration improved pulmonary alveolarization and angiogenesis(P<0.01,P<0.01,P<0.001,and P<0.05 for mean linear intercept,septal counts,vascular medial thickness index,and microvessel density respectively).Meanwhile,treatment with hUC-MSCs iT ameliorated right ventricular hypertrophy(for Fulton’s index,P<0.01),and relieved reduced nephr

关键词： Mesenchymal stem cell Hyperoxia Multiple organ injury bronchopulmonary dysplasia Heme oxygenase-1 JAK/STAT pathway

Respiratory management of extremely low birth weight infants: survey of neonatal specialists

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World Journal of Pediatrics 2016年第3期12卷 314-319页

作者： Sumesh Parat Maroun Jean Mhanna Department of Pediatrics Division of NeonatologyCase Western Reserve University School of MedicineMetroHealth Medical CenterClevelandOhioUSA

Background:To investigate strategies used for the management of respiratory distress syndrome(RDS)and bronchopulmonary dysplasia(BPD)in extremely low birth weight(ELBW)***:A survey of neonatal specialists working in US academic institutions with fellowship training ***:Eighty percent(72/89)of the identifi ed academic institutions had at least one physician who responded to the *** respondents,85%(171/201)agreed or strongly agreed to use continuous positive airway pressure(CPAP)initially for the management of RDS,and the majority agreed or strongly agreed to use a fraction of inspired oxygen(FiO2)≥0.4 and a mean airway pressure(MAP)≥10 cm H2O as a criteria for surfactant therapy;and 73%(146/200)sometimes or always used caffeine to prevent *** 25%(50/202)sometimes or almost always used steroids to prevent or treat *** indications to use steroids were 3 or more extubation failures or inability to extubate beyond 8 weeks of ***:Variability in treatment strategies of ELBW is common among neonatal ***,the majority of the respondents agreed or strongly agreed to use early CPAP for the management of RDS,consider a FiO2≥0.4 and a MAP≥10 cm H2O as criteria for surfactant therapy,and sometimes or almost always used caffeine to prevent *** continue to have a role in the management of BPD in infants who are diffi cult to extubate.

关键词： bronchopulmonary dysplasia extremely low birth weight infants respiratory distress syndrome survey

Is early patent ductus arteriosus ligation helpful in premature neonates? A 10-year retrospective study

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World Journal of Pediatrics 2022年第5期18卷 350-357页

作者： Anip Garg Naveen Athiraman Elizabeth Jenkins David Crossland Prakash Kannan Loganathan Neonatal Unit Royal Victoria InfirmaryNewcastleUK Paediatric Cardiology Freeman HospitalNewcastleUK Neonatal Unit James Cook University HospitalMarton RoadMiddlesbrough TS43BWUK

Background To compare short and long outcomes between early(≤28 days)(EL)and late ligation(LL)*** explore factors predicting early extubation(≤7 days)after patent ductus arteriosus(PDA)*** We conducted a single center,retrospective cohort study of preterm infantsbronchopulmonary dysplasia(BPD)or death(96%vs.98%,P=0.64)and long-term clinical outcomes including Bayley's assessment at 2 years corrected *** infants in the EL group developed severe BPD(63%vs.81%,P=0.02).Age at ligation had adjusted odds ratio of 1.04 with over lapping confidence interval(95%CI 1.0-1.1,P=0.02)for severe BPD/*** was no difference in day of extubation between the EL and LL group(8 days vs.7 days,P=0.85).Left atrium/aortic root ratio of ≥1.75 would give sensitivity of 41% and 80% specificity for early extubation(area under the curve of 0.61).There was marginal reduction of hospital stay in the EL group[113(105-121)days vs.115(107-123)days;log rank P=0.026].Conclusion EL can be delivered safely with a clinically important lower incidenee of severe BPD and shorter duration of hospital stay compared to LL.

关键词： bronchopulmonary dysplasia Extubation Patent ductus arteriosus ligation

Pulmonary hypertension in extremely low birth weight infants:characteristics and outcomes

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World Journal of Pediatrics 2014年第1期10卷 46-52页

作者： Wambui Waruingi Maroun Jean Mhanna Department of Pediatrics Division of NeonatologyMetro Health Medical CenterCase Western Reserve University School of MedicineClevelandOH 44109USA

Background:To determine the characteristics and outcomes of pulmonary arterial hypertension(PAH)in extremely low birth weight(ELBW)***:A retrospective case-control study of all ELBW infants admitted to a level III neonatal intensive care unit(NICU)between January 1,2003 and December 31,***:During the study period,450 ELBW infants were admitted.6.4%(29/450)were diagnosed with PAH and were matched to 26 *** mean gestational age of infants with PAH and their controls were similar[24.5±1.3 vs.24.9±1.8 weeks(P=0.26)];however the cases were smaller at birth than were controls[640.7±119.5 vs.727.0±184.5 g(P=0.04)].The diagnosis of PAH was made at a mean postnatal age of 131.8±53.7 *** with PAH had a higher rate of intrauterine exposure to illicit maternal drug use[12/29(41%)vs.1/25(4%);P=0.001],a longer duration of initial mechanical ventilation[74.9±28.3 vs.59.1±27.8 days;(P=0.04)],a higher incidence of severe BPD[23/29(79%)vs.13/26(50%);P=0.02],and a greater NICU mortality rate[12/29(41%)vs.4/26(15%);P=0.04].Conclusion:PAH in ELBW infants is associated with maternal illicit drug use in pregnancy,longer exposure to mechanical ventilation,severe bronchopulmonary dysplasia and a significant increase in early mortality.

关键词： bronchopulmonary dysplasia echocardiography illicit drug use mechanical ventilation prenatal exposure