Neonatal bronchopulmonary dysplasia increases neuron apoptosis in hippocampus through HIF-1α and p53 pathway
作者单位：复旦大学附属儿科医院新生儿科
会议名称：《2015年泛长三角围产医学学术年会暨浙江省围产医学学术...》
会议日期：2015年
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
关 键 词：Bronchopulmonary dysplasia hippocampus neuron apoptosis HIF-1α p53
摘 要：Neonatal bronchopulmonary dysplasia(BPD)may lead to an increased risk for brain *** present study aims to investigate the effects of neonatal BPD on neuron apoptosis in hippocampus and cognitive function and explore the underlying *** results showed that pups of BPD model had more apoptosis cells in the hippocampus and longer escape latency in the Morris maze *** Caspase dependent and Caspase nondependent signal pathways were *** examinations showed an elevated p53 level by BPD via HIF-la *** Caspase-3 in the hippocampus was suppressed by both HIF-la and p53 *** findings suggested that neonatal BPD caused impaired cognitive function and neuron apoptosis in hippocampus via p53 and HIF-lα.Although the precise mechanism needs further investigation,this study provided a new evidence of impaired CNS developmental outcomes of BPD.