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Effect of sumatriptan on gastric emptying:A crossover study using the breathid system

World Journal of Gastroenterology 2012年第26期18卷 3415-3419页

作者： Yasunari Sakamoto Yusuke Sekino Eiji Yamada Takuma Higurashi Hidenori Ohkubo Eiji Sakai Hiroki Endo Hiroshi Iida Takashi Nonaka Koji Fujita Masato Yoneda Tomoko Koide Hirokazu Takahashi Ayumu Goto Yasunobu Abe Eiji Gotoh Shin Maeda Atsushi Nakajima Masahiko Inamori Gastroenterology Division Yokohama City University Hospital3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Department of Medical Education Yokohama City University School of Medicine3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan Office of Postgraduate Medical Education Yokohama City University Hospital3-9 FukuuraKanazawakuYokohamaKanagawa 236-0004Japan

AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13 C breath test(breathid system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover *** subjects fasted overnight and were randomly assigned to receive a test meal(200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg(sumatriptan condition),or the test meal alone(control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13 C-acetic acid breath test performed continually using the breathid ***,using Oridion Research Software(β version),the time taken for emptying of 50% of the labeled meal(T 1/2) similar to the scintigraphy lag time for 10% emptying of the labeled meal(T lag),the gastric emptying coefficient(GEC),and the regression-estimated constants(β and κ) were *** statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank ***:In the sumatriptan condition,significant differences compared with the control condition were found in T 1/2 [median 131.84 min(range,103.13-168.70) vs 120.27 min(89.61-138.25);P = 0.0016],T lag [median 80.085 min(59.23-125.89) vs 61.11 min(39.86-87.05);P = 0.0125],and β [median 2.3374(1.6407-3.8209) vs 2.0847(1.4755-2.9269);P = 0.0284].There were no significant differences in the GEC or κ between the 2 ***:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.

关键词： Sumatriptan Gastric emptying Breath test Liquid meal breathid system

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