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High accuracy object detection via bounding box regression network

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Frontiers of Optoelectronics 2019年第3期12卷 324-331页

作者： Lipeng SUN Shihua ZHAO Gang LI Binbing LIU State Grid Hunan Electric Power Corporation Limited Research Institute Changsha 410007China State Grid Hunan Electric Power Corporation Limited Changsha 410007China School of Optical and Electronics Information Huazhong University of Science and TechnologyWuhan 430074China

As one of the primary computer vision problems, object detection aims to find and locate semantic objects in digital images. Different with object classification, which only recognizes an object to a certain class, object detection also needs to extract accurate locations of objects. In the state-of-the-art object detection algorithms, bounding box regression plays a critical role in order to achieve high localization accuracy. Almost all the popular deep learning based object detection algorithms have utilized bounding box regression for fine tuning of object locations. However, while bounding box regression is widely used, there is few study focused on the underlying rationale, performance dependencies, and performance evaluation. In this paper, we proposed a dedicated deep neural network for bounding box regression, and presented several methods to improve its performance. Some ad hoc experiments are conducted to prove the effectiveness of the network. Also, we apply the network as an auxiliary module to the faster R-CNN algorithm and test them on some real-world images. Experiment results show certain performance improvements on detection accuracy in term of mean IOU.

关键词： deep learning object detection bounding box regression IOU distribution

MCC1019,a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel,potent anticancer candidate

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Acta Pharmaceutica Sinica B 2019年第5期9卷 1021-1034页

作者： Sara Abdelfatah Angela Berg Qi Huang Li Jun Yang Sami Hamdoun Anette Klinger Henry J.Greten Edmond Fleischer Thorsten Berg Vincent K.W.Wong Thomas Efferth Department of Pharmaceutical Biology Institute of Pharmacy and BiochemistryJohannes Gutenberg UniversityMainz55128Germany Leipzig University Institute of Organic ChemistryLeipzig04103Germany State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina MicroCombiChem GmbH Wiesbaden65203Germany Abel Salazar Institute of Biomedical Sciences University of PortoPorto4099-003Portugal

Polo-like kinase(PLK1) has been identified as a potential target for cancer *** a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain(PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethylbenzofuran-2-carboxylic acid ethyl ester(designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1 PBD was confirmed using fluorescence polarization and microscale *** compound exerted specificity towards PLK1 over PLK2 and PLK3. MCC1019 showed cytotoxic activity in a panel of different cancer cell lines. Mechanistic investigations in A549 lung adenocarcinoma cells revealed that MCC1019 induced cell growth inhibition through inactivation of AKT signaling pathway, it also induced prolonged mitotic arrest—a phenomenon known as mitotic catastrophe, which is followed by immediate cell death via apoptosis and necroptosis. MCC1019 significantly inhibited tumor growth in vivo in a murine lung cancer model without affecting body weight or vital organ size, and reduced the growth of metastatic lesions in the lung. We propose MCC1019 as promising anti-cancer drug candidate.

关键词： Polo-like kinase PLK1 Polo box domain Mono-targeted therapy Cell cycle Necroptosis Spindle damage

Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park Sun Bok Choi Won-Seok Jung Su-Young Jung Jung-Hee Cho Mee-Ok Choi Ho-Joon Song Sung-Joo Park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea Hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 *** also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis High-mobility group box protein-1

Structural and functional analysis of a MADS box containing genomic DNA sequence cloned from rice

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Science China(Life Sciences) 1998年第6期41卷 561-568页

作者：孟征刘国振许智宏唐广王宁陈润生朱立煌 1. Institute of Genetics Chinese Academy of Sciences 100101 Beijing China 2. Shanghai Institute of Plant Physiology Chinese Academy of Sciences 200032 Shanghai China 3. Institute of Biophysics Chinese Academy of Sciences 100101 Beijing China

A putative MADS box gene (RgMADS1) was cloned by screening a rice genomic library with a heterogeneous MADS box probe derived from \%Antirrhinum majus squamosa\% gene. Sequencing and Southern analysis showed that RgMADS1 contains a highly conserved MADS box sequence, whereas the rice genome contains numbers of MADS box genes. A chimera gene of RgMADS1 under the control of CaMV 35S promoter was constructed and used to transform \%Arabidopsis.\% Some transformants exhibited abnormal phenotypes in their flowers, which were reflected in the floral structure, number and setting position. Therefore, RgMADS1 is likely a member of rice MADS box gene family and may be involved in the floral establishment and function control in the rice developmental process.

关键词： rice MADS box genes gene cloning homeotic gene.

Grey Relational Analysis Coupled with Principal Component Analysis Method For Optimization Design of Novel Crash box Structure

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Journal of Beijing Institute of Technology 2019年第3期28卷 577-584页

作者： Shuang Wang Dengfeng Wang State Key Laboratory of Automotive Simulation and Control Jilin University

Crashworthiness and lightweight optimization design of the crash box are studied in this paper. For the initial model, a physical test was performed to verify the model. Then, a parametric model using mesh morphing technology is used to optimize and decrease the maximum collision force (MCF) and increase specific energy absorption (SEA) while ensure mass is not increased. Because MCF and SEA are two conflicting objectives, grey relational analysis (GRA) and principal component analysis (PCA) are employed for design optimization of the crash box. Furthermore, multi-objective analysis can convert to a single objective using the grey relational grade (GRG) simultaneously, hence, the proposed method can obtain the optimal combination of design parameters for the crash box. It can be concluded that the proposed method decreases the MCF and weight to 16.7% and 29.4% respectively, while increasing SEA to 16.4%. Meanwhile, the proposed method in comparison to the conventional NSGA-Ⅱ method, reduces the time cost by 103%. Hence, the proposed method can be properly applied to the optimization of the crash box.

关键词： crash box optimization maximum collision force (MCF) specific energy absorption (SEA) grey relational analysis (GRA) principal component analysis (PCA)

Analysis of Comb box Assembly Performance

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Journal of China Textile University(English Edition) 1998年第1期15卷 64-66页

作者：周旭东 Coll of Textile Shanghai Univ of Engineering Science Shanghai China

Some experimental results which support a new techniquefor detecting comb box assemblies are *** which artificial intelligence(A.I.)can play in ex-tending this technique to real-time applications on combbox of gill ma... 详细信息

关键词： comb box gill machine random input artificial intelligence.

High-mobility group box 1 protein and its role in severe acute pancreatitis

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World Journal of Gastroenterology 2015年第5期21卷 1424-1435页

作者： Xiao Shen Wei-Qin Li Department of General Surgery Jinling HospitalMedical School of Nanjing University

The high mobility group box 1(HMGB1),which belongs to the subfamily of HMG-1/-2,is a highly conserved single peptide chain consisting of 215 amino acid residues with a molecular weight of approximately 24894 ***1 is a ubiquitous nuclear protein in mammals and plays a vital role in inflammatory *** pancreatitis is one of the most common causes of acute abdominal pain with a poor *** pancreatitis is an acute inflammatory process of the pancreas(duration of less than six months),for which the severe form is called severe acute pancreatitis(SAP).More and more studies have shown that HMGB1 has a bidirectional effect in the pathogenesis of *** HMGB1 can aggravate the pancreatic inflammatory process,whereas intracellular HMGB1 has a protective effect against *** mechanism of HMGB1 is multiple,mainly through the nuclear factor-κB *** for advanced glycation endproducts and toll-like receptors(TLR),especially TLR-2 and TLR-4,are two major types of receptors mediating the inflammatory process triggered by HMGB1 and may be also the main mediators in the pathogenesis of ***1 inhibitors,such as ethyl pyruvate,pyrrolidine dithiocarbamate and Scolopendra subspinipes mutilans,can decrease the level of extracellular HMGB1 and are the promising targets in the treatment of SAP.

关键词： High mobility group box 1 protein Inhibitors Infla

Erosion problem in tool steel using cold box core-making process

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China Foundry 2019年第3期16卷 204-210页

作者： Eduardo Rodríguez Alberto Pérez Rafael David Mercado-Solis Velasco-Téllez Abraham Omar Jimenez Martin Flores Marco Aurelio Gonzalez Jesus Ibarra Universidad de Guadalajara Departamento de Ingeniería de Proyectos/CUCEI CONACyT México Facultad de Ingeniería Mecánica y Eléctrica UANL México Nemak México S.A. García México Instituto Tecnológico José Mario Molina Pasquel y Henríquez Unidad Zapopan México

This paper presents the erosion results of the AISI H13 steel impinged by resin-bonded silica sand, using a testing rig that closely simulates the real blowing conditions during industrial core-making. Steel specimens were heat treated to obtain hardness of 294, 445 and 595 HV200 (29, 45 and 55 HRC). Erosion tests were carried out at impingement angles from 20° to 90° and air drag pressures of 1.38, 2.07 and 2.76 bar (20, 30 and 40 psi). The main results are summarized as follows:(i) The harder material, the lower erosion;(ii) the maximum erosion rate is at 30°;(iii) Little difference in erosion rate at impact angle of 60° and 90° for a constant pressure tested regardless of the hardness level;(iv) As the pressure increases, so does the erosion rate, being more sensitive for low impact angles. Finally, a differential form of the general erosion equation is applied on a practical core-making case to evaluate the erosion rate of the H13 steel at 30° and 90° impingement angles.

关键词： erosion cold box core-making H13 tool steel resin coated silica sand

Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 898-903页

作者： Jia-Qian Jiang Cui Li Cong-Xian Cui Yu-Na Ma Gui-Qiu Zhao Xu-Dong Peng Qiang Xu Qian Wang Guo-Qiang Zhu Chen-Yu Li Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To investigate the inflammatory amplification effect of high-mobility group box 1(HMGB1) in Aspergillus fumigatus(A. fumigatus) keratitis and the relationship between lectin-like oxidized low-density lipoprotein receptor 1(LOX-1) and HMGB1 in keratitis immune ***: Phosphate buffer saline(PBS), and boxb were injected into BALB/c mice subconjunctivally before the corneas were infected with A. fumigatus. RAW264.7 macrophages and neutrophils were pretreated with PBS and boxb to determine the HMGB1 inflammatory amplification effects. Abdominal cavity extracted macrophages were pretreated with boxb and Poly(I)(a LOX-1 inhibitor) before A. fumigatus hyphae stimulation to prove the the relationship between the two molecules. LOX-1, interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), macrophage inflammatory protein-2(MIP-2) and IL-10 were assessed by polymerase chain reaction and Western ***: Pretreatment with boxb exacerbated corneal inflammation. In macrophages and neutrophils, A. fumigatus induced LOX-1, IL-1β, TNF-α and MIP-2 expression in boxb group was higher than those in PBS group. Poly(I) treatments before infection alleviated the proinflammatory effects of boxb in abdominal cavity extracted macrophages. Pretreatment with boxb did not influence Dectin-1 mRNA levels in macrophages and ***: In fungal keratitis, HMGB1 is a proinflammatory factor in the first line of immune response. HMGB1 mainly stimulates neutrophils and macrophages to produce inflammatory cytokines and chemokines during the immune response. LOX-1 participates in HMGB1 induced inflammatory exacerbation in A. fumigatus keratitis.

关键词： Aspergillus fumigatus keratitis high-mobility group box 1 LOX-1