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Current Medical Science 2023年第5期43卷 998-1004页

作者： Ting-wei WANG Jian GONG Yang WANG Zhen LIANG Ke-liang PANG Jie-si WANG Zhi-guo ZHANG Chun-yan ZHANG Yue ZHOU Jun-chang LI Yan-ni WANG Yong-jie ZHOU School of Public Health Lanzhou UniversityLanzhou 730000China Shenzhen Mental Health Center Shenzhen Kangning HospitalShenzhen 518000China College of Management Shenzhen UniversityShenzhen 518000China School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518000China School of Pharmaceutical Sciences IDG/McGovern Institute for Brain ResearchTsinghua University-Peking University Joint Center for Life SciencesTsinghua UniversityBeijing 100000China CAS Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100000China

Objective Non-suicidal self-injury(NSSI)has a higher prevalence in adolescents with depressive disorders than in community *** study examined the differences in NSSI behaviors between adolescents with unipolar depression(UD)and those with bipolar depression(BD).Methods Adolescents with UD or BD were recruited from 20 general or psychiatric hospitals across *** methods,frequency,and function of NSSI were assessed by Functional Assessment of *** Beck Suicide Ideation Scale was used to evaluate adolescents’suicidal ideation,and the 10-item Kessler Psychological Distress Scale to estimate the anxiety and depression *** The UD group had higher levels of depression(19.16 vs.17.37,F=15.23,Pdepression and anxiety symptoms,indicating the importance of adequate treatment of depression and anxiety in preventing and intervening adolescents’NSSI behaviors.

关键词： non-suicidal self-injury unipolar depression bipolar depression depression anxiety adolescent

Comparison of Plasma Levels of Tryptophan Metabolites between Healthy People and Patients of bipolar depression at Various Age and Gender

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Journal of Biomedical Science and Engineering 2020年第6期13卷 120-129页

作者： Hiroi Tomioka Junichi Masuda Akikazu Takada Akira Iwanami Department of Psychiatry Showa University School of Medicine Tokyo Japan Department of Psychiatry Showa University Northern Yokohama Hospital Yokohama Japan Global Application Development Center Shimadzu Corporation Kanagawa-ken Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: Plasma levels of TRP are not different between HC and patients of BDII. Serotonin (5-HT) levels are higher in BDII than HC. Plasma levels of 5-HIAA of HC are higher than those of old women of BDII, but lower in young women of BDII. Plasma levels of kynurenine (KYN) of HC are not different from those of patients of BDII. Conclusion: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation and lower transporter biding may increase plasma levels of 5-HT in patients of BD.

关键词： depression Monopolar depression bipolar depression Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine SSRI (Selective Serotonin Reuptake Inhibitor) SNRI (Serotonin Norepinephrine Reuptake Inhibitor) Anxiolytic Antipsychotic

The effect of lithium on resting-state brain networks in patients with bipolar depression

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Journal of Translational Neuroscience 2016年第1期1卷 43-51页

作者： Chunhong Liu Xin Ma Yuan Zhen Yu Zhang Lirong Tang Feng Li Changle Tie Chuanyue Wang Beijing Key Laboratory of Mental Disorders Department of Psychiatry Beijing Anding Hospital Capital Medical University Beijing 100088 China Center of Brain Disorders Beijing Institute for Brain Disorders Beijing 100069 China Bioimaging Core Faculty of Health SciencesUniversity of Macao Macao SAR China

Objective： Although lithium has been a commonly prescribed neurotrophic/neuroprotective mood-stabilizing agents, its effect on spontaneous brain activity in patients with bipolar depression remains unclear. The aim of this study is to reveal the basic mechanism underlying the pathological influences of lithium on resting-state brain function of bipolar depression patients. Methods：97 subjects including 9 bipolar depression patients with lithium treatment, 19 bipolar depression patients without lithium treatment and 69 healthy controls, were recruited to participate in this study. Amplitude of low-frequency fluctuation （ ALFF ） and fractional amplitude of low-frequency fluctuation （ fALFF） were used to capture the changes of spontane-ous brain activity among different groups. In addition, further analysis in terms of Hamilton depression Rating Scale, the number of depressive episodes, and illness duration in pooled bipolar depression patients were conducted, which combined FLEF and fALEF to identify the basic neural features of bipolar depression patients. Results： It was observed from the imaging results that both the bipolar depression patients receiving lithium treatment and healthy control subjects showed signifi-cantly decreased ALFF/fALFF values in the right anterior cingulate cortex and right middle frontal gyrus compared to that from the bipolar depression patients without lithium treatmetn. The ALFF values of the right＆amp;nbsp;middle temporal gyrus was also found to be negative related to the number of depressive episode and the total episodes. Conclusions：Our findings suggested that the bipolar depression subjects were identified to have ab-normal ALFF/ fALFF in the corticolimbic systems, in-cluding regions like right anterior cingulate cortex, bilateral middle frontal gyrus, right orbital frontal gyrus, and right middle temporal gyrus. In addition, it was also revealed that the decreased ALFF/fALFF in the right anterior cingulate cortex and right middle f

关键词： bipolar depression lithium functional magnetic resonance imaging ( fMRI ) amplitude of low-frequency fluctuation ( ALFF ) fractional amplitude of low-frequency fluctuation (fALFF)

Antidepressants for bipolar disorder A meta-analysis of randomized, double-blind, controlled trials

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Neural Regeneration Research 2013年第31期8卷 2962-2974页

作者： Yingli Zhang Huan Yang Shichang Yang Wei Liang Ping Dai Changhong Wang Yalin Zhang Mental Health Institute Second Xiangya Hospital Central South University Psychological Counseling Center Second Affiliated Hospital of Xinxiang Medical University Department of Psychology Xinxiang Medical University Department of Clinical Psychology Second Affiliated Hospital of Xinxiang Medical University Sichuan University Library

OBJECTIVE： To examine the efficacy and safety of short-term and long-term use of antidepres- sants in the treatment of bipolar disorder. DATA SOURCES： A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords ＂bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed mania and depression, rapid cycling and bipolar disorder＂, AND ＂antidepressant agent, antidepressive agents second- generation, antidepressive agents tricyclic, monoamine oxidase inhibitor, noradrenaline uptake in- hibitor, serotonin uptake inhibitor, and tricyclic antidepressant agent＂ were used. The studies that were listed in the reference list of the published papers but were not retrieved in the above-mentioned databases were supplemented. STUDY SELECTION： Studies selected were double-blind randomized controlled trials assessing the efficacy and safety of antidepressants in patients with bipolar disorder. All participants were aged 18 years or older, and were diagnosed as having primary bipolar disorder. Antidepressants or antidepressants combined with mood stabilizers were used in experimental interventions. Placebos, mood stabilizers, antipsychotics and other antide pressants were used in the control interventions. Studies that were quasi-randomized studies, or used antidepressants in combination with antipsy- chotics in the experimental group were excluded. All analyses were conducted using Review Man- ager 5.1 provided by the Cochrane Collaboration.

关键词： neural regeneration evidence-based medicine bipolar disorder bipolar depression antidepressant response switching to mania suicidality meta-analysis grants-supported paper neuroregeneration

Differences of Plasma Levels of Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, and Kynurenine between Healthy People and Patients of Major Monopolar depression at Various Age and Gender

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Food and Nutrition Sciences 2020年第6期11卷 431-441页

作者： Hiroi Tomioka Junichi Masuda Akikazu Takada Akira Iwanami Department of Psychiatry School of Medicine Showa University Tokyo Japan Department of Psychiatry Showa University Northern Yokohama Hospital Yokohama Japan Global Application Development Center Shimadzu Corporation Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of major monopolar depression (MMD). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: There are no significant differences between plasma levels of TRP between HC and MMD. Plasma levels of TRP of HC are higher in young men, young women, old men, and old women in this order. Serotonin (5-HT) levels are higher in MMD than HC. Plasma levels of 5-HIAA of HC are also higher than those of patients of MMD. Plasma levels of kynurenine (KYN) of healthy old men and old women are higher than those of young men and old women. Plasma levels of KYN are higher in old women and young men of MMD than those of HC. Conclusion: Plasma levels of 5-HT are higher in patients of MMD than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation may increase plasma levels of 5-HT in MMD.

关键词： depression Monopolar depression bipolar depression Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid Anthranilic Acid Xanthurenic Acid Indole-3-Acetic Acid SSRI (Selective Serotonin Reuptake Inhibitor) SNRI (Serotonin Norepinephrine Reuptake Inhibitor)