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Applications of nanogenerators for biomedical engineering and healthcare systems

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InfoMat 2022年第2期4卷 53-109页

作者： Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti College of Electrical engineering Qingdao UniversityQingdaoChina Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong Institute for Advanced Interdisciplinary Research(iAIR)University of JinanJinanChina College of Electronic Information Qingdao UniversityQingdaoChina Department of Pediatric Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina College of Physics Qingdao UniversityQingdaoChina Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresdenGermany Center for Advancing Electronics Dresden Technische Universität DresdenDresdenGermany College of Biological Science and Technology University of JinanJinanChina School of Chemistry and Chemical engineering University of JinanShandongJinanChina College of Energy Soochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhouChina Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhouChina Centre of Polymer and Carbon Materials Polish Academy of SciencesZabrzePoland Institute for Complex Materials IFW DresdenDresdenGermany Institute of Environmental Technology VŠB-Technical University of OstravaOstravaCzech Republic School of Information Science and engineering University of JinanJinanChina Shandong Provincial Key Laboratory of Network Based Intelligent Computing University of JinanJinanChina State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinanChina College of Chemical engineering China University of Petroleum(East China)QingdaoChina Dresden Center for Computational Materials Science Technische Universität DresdenDresdenGermany The Dresden Center for Intelligent Materials(DCIM) Technische Universität DresdenDresdenGermany

The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks.

关键词： biomedical engineering healthcare implantable devices nanogenerators self-powered devices sensors

Millimetric devices for nerve stimulation:a promising path towards miniaturization

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Neural Regeneration Research 2024年第8期19卷 1702-1706页

作者： Ryan M.Dorrian Anna V.Leonard Antonio Lauto Spinal Cord Injury Research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerve stimulation is a rapidly developing field,demonstrating positive outcomes across several conditions.Despite potential benefits,current nerve stimulation devices are large,complicated,and are powered via implanted pulse generators.These facto rs necessitate invasive surgical implantation and limit potential applications.Reducing nerve stimulation devices to millimetric sizes would make these interventions less invasive and facilitate broader therapeutic applications.However,device miniaturization presents a serious engineering challenge.This review presents significant advancements from several groups that have overcome this challenge and developed millimetricsized nerve stimulation devices.These are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receive ultrasound power.We highlight key design elements,findings from pilot studies,and present several considerations for future applications of these devices.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerve stimulation

Transfer Learning-Based Class Imbalance-Aware Shoulder Implant Classification from X-Ray Images

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Journal of Bionic engineering 2024年第2期21卷 892-912页

作者： Marut Jindal Birmohan Singh Department of Computer Science and engineering Sant Longowal Institute of Engineering and TechnologySangrur148106PunjabIndia

Total shoulder arthroplasty is a standard restorative procedure practiced by orthopedists to diagnose shoulder arthritis in which a prosthesis replaces the whole joint or a part of the joint.It is often challenging for doctors to identify the exact model and manufacturer of the prosthesis when it is unknown.This paper proposes a transfer learning-based class imbalance-aware prosthesis detection method to detect the implant’s manufacturer automatically from shoulder X-ray images.The framework of the method proposes a novel training approach and a new set of batch-normalization,dropout,and fully convolutional layers in the head network.It employs cyclical learning rates and weighting-based loss calculation mechanism.These modifications aid in faster convergence,avoid local-minima stagnation,and remove the training bias caused by imbalanced dataset.The proposed method is evaluated using seven well-known pre-trained models of VGGNet,ResNet,and DenseNet families.Experimentation is performed on a shoulder implant benchmark dataset consisting of 597 shoulder X-ray images.The proposed method improves the classification performance of all pre-trained models by 10–12%.The DenseNet-201-based variant has achieved the highest classification accuracy of 89.5%,which is 10%higher than existing methods.Further,to validate and generalize the proposed method,the existing baseline dataset is supplemented to six classes,including samples of two more implant manufacturers.Experimental results have shown average accuracy of 86.7%for the extended dataset and show the preeminence of the proposed method.

关键词： biomedical engineering Artificial intelligence Total shoulder arthroplasty Prosthesis identification biomedical image classification

Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing

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Chinese Journal of Chemical engineering 2024年第4期68卷 156-164页

作者： Kexin Zhang Wenmin Zhang Heng An Zhe Huang Yanzhen Wen Xiangyu Jiao Yongqiang Wen College of Chemical engineering and Technology Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research InstituteSchool of Chemistry&Biological EngineeringUniversity of Science&Technology BeijingBeijing 100083China

Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on patients.Mesenchymal stem cells(MSCs)promote diabetic wound healing.Particularly when MSCs aggregate into multicellular spheroids,their therapeutic effect is enhanced.However,traditional culture platforms are inadequate for the efficient preparation and delivery of MSC spheroids,resulting in inefficiencies and inconveniences in MSC spheroid therapy.In this study,a three-dimensional porous nanofibrous dressing(NFD)is prepared using a combination of electrospinning and homogeneous freeze-drying.Using thermal crosslinking,the NFD not only achieves satisfactory elasticity but also maintains notable cytocompatibility.Through the design of its structure and chemical composition,the NFD allows MSCs to spontaneously form MSC spheroids with controllable sizes,serving as MSC spheroid delivery systems for diabetic wound sites.Most importantly,MSC spheroids cultured on the NFD exhibit improved secretion of vascular endothelial growth factor,basic fibroblast growth factor,and hepatocyte growth factor,thereby accelerating diabetic wound healing.The NFD provides a competitive strategy for MSC spheroid formation and delivery to promote diabetic wound healing.

关键词： Electrospinning Homogenization biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing

Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

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Nano Research 2024年第5期17卷 4244-4258页

作者： Yifeng Nie Dong Han Xiang Li CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

With the advent of tissue engineering and biomedicine,the creation of extracellular matrix(ECM)biomaterials for in vitro applications has become a prominent and promising strategy.These ECM materials provide physical,biochemical,and mechanical properties that guide cellular behaviors,such as proliferation,differentiation,migration,and apoptosis.Because micro-and nano-patterned materials have a unique surface topology and low energy replication process that directly affect cellular biological behaviors at the interface,the fabrication of micro-nano pattern biomaterials and the regulation of surface physical and chemical properties are of great significance in the fields of cell regulation,tissue engineering,and regenerative medicine.Herein,we provide a comprehensive review of the progress in the fabrication and application of patterned materials based on the coupling of mechanical action at the micro-and nano-meter scale,including photolithography,micro-contact printing,electron beam lithography,electrospinning,and 3D printing technology.Furthermore,a summary of the fabrication process,underlying principles,as well as the advantages and disadvantages of various technologies are reviewed.We also discuss the influence of material properties on the fabrication of micro-and nano-patterns.

关键词： micro/nano hybrid materials patterning fabrication techniques extracellular matrix substrate-cell interaction biomedical engineering

engineering organoid microfluidic system for biomedical and health engineering:A review

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Chinese Journal of Chemical engineering 2021年第2期34卷 244-254页

作者： Yifan Xing Junyu Liu Xiaojie Guo Haipeng Liu Wen Zeng Yi Wang Chong Zhang Yuan Lu Dong He Shaohua Ma Yonghong He Xin-Hui Xing Key Laboratory for Industrial Biocatalysis Ministry of Education of ChinaDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Centre for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China School of Chemical engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Institute of Biopharmaceutical and Health engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of biomedical Health Technology and engineering Shenzhen Bay LaboratoryShenzhen 518055China

In recent years,organoid technology,i.e.,in vitro three-dimensional(3D)tissue culture,has attracted increasing attention in biomedical engineering.Organoids are cell complexes induced by differentiation of stem cells or organ-progenitor cells in vitro using 3D culture technology.They can replicate the key structural and functional characteristics of the target organs in vivo.With the opening up of this new field of health engineering,there is a need for engineering-system approaches to the production,control,and quantitative analysis of organoids and their microenvironment.Traditional organoid technology has limitations,including lack of physical and chemical microenvironment control,high heterogeneity,complex manual operation,imperfect nutritional supply system,and lack of feasible online analytical technology for the organoids.The introduction of microfluidic chip technology into organoids has overcome many of these limitations and greatly expanded the scope of applications.engineering organoid microfluidic system has become an interdisciplinary field in biomedical and health engineering.In this review,we summarize the development and culture system of organoids,discuss how microfluidic technology has been used to solve the main technical challenges in organoid research and development,and point out new opportunities and prospects for applications of organoid microfluidic system in drug development and screening,food safety,precision medicine,and other biomedical and health engineering fields.

关键词： Organoids Stem cell Culture system Microfluidics biomedical engineering Human health

Plasma-activated interfaces for biomedical engineering

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Bioactive Materials 2021年第7期6卷 2134-2143页

作者： Pei Liu Guomin Wang Qingdong Ruan Kaiwei Tang Paul K.Chu Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloon999077Hong KongChina

As an important phenomenon to monitor disease development,cell signaling usually takes place at the interface between organisms/cells or between organisms/cells and abiotic materials.Therefore,finding a strategy to build the specific biomedical interfaces will help regulate information transmission and produce better therapeutic results to benefit patients.In the past decades,plasmas containing energetic and active species have been employed to construct various interfaces to meet biomedical demands such as bacteria inactivation,tissue regeneration,cancer therapy,and so on.Based on the potent functions of plasma modified surfaces,this mini-review is aimed to summarize the state-of-art plasma-activated interfaces and provide guidance to researchers to select the proper plasma and processing conditions to design and prepare interfaces with the optimal biological and related functions.After a brief introduction,plasma-activated interfaces are described and categorized according to different criteria including direct plasma-cells interfaces and indirect plasma-material-cells interfaces and recent research activities on the application of plasma-activated interfaces are described.The authors hope that this mini-review will spur interdisciplinary research efforts in this important area and expedite associated clinical applications.

关键词： Plasma-assisted processes Bioactive interfaces biomedical engineering

Proceedings of the 20th Annual International Conference of the IEEE engineering in Medicine and Biology soceity,vol.20:biomedical engineering towards the year 2000 and beyond,1998,China,part 1/ ed.by

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2010 international conference on biomedical engineering and computer science

1998年

作者： ed.by H.K.Chang and Y.T.Zhang.

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