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A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration

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Journal of Materials Science & Technology 2021年第20期79卷 35-45页

作者： Zhen Geng Xueping Li Luli Ji Zhaoyang Li Zhenduo Cui Jing Wang Jingyuan Cui Xianjin Yang Changsheng Liu Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and TechnologyShanghai200237China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China Engineering Research Center for Biomedical Materials of the Ministry of Education East China University of Science and TechnologyShanghai200237China The State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and TechnologyShanghai200237China

As the population ages,more and more people are suffering from osteoarthritis(OA),resulting in an increasing requirement for joint *** modification to improve the topology and composition of the implants has been proved to be an effective way to improve the primary stability and long-term success rate of joint *** this work,a bionic micro/nano-structure accompanied with a strontium-substituted hydroxyapatite(SrHA)coating was fabricated on titanium(Ti)surface via electrochemical corrosion,ultrasonic treatment,and hydrothermal deposition *** vitro study demonstrated that the bionic structure and the bioactive apatite could synergistically increase the expressions of integrin-related gene(ITGα5β1)and osteoblastic genes(Col-I and OCN),and thus promote osteoblast *** addition,owing to the anti-bone resorption property of Sr^(2+),the coating could effectively inhibit osteoclast differentiation and *** a word,the prepared samples not only promoted osteogenesis but also inhibited *** in vivo experiment via a rabbit model found that the bionic structured surface provided the pore for new bone ingrowth,which was beneficial to the mechanical interlocking between the implant and ***,the bionic structure and bioactive SrHA coating had a synergistic effect on promoting bone formation,osseointegration,and bone-implant bonding *** study therefore presented a new strategy to fabricate bio-functionalized Ti-based implants for potential application in orthopedics field.

关键词： Bionic structure bioactive apatite Osteoclast activity Osseointegration Bone-implant bonding strength

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