A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration

作     者：Zhen Geng Xueping Li Luli Ji Zhaoyang Li Zhenduo Cui Jing Wang Jingyuan Cui Xianjin Yang Changsheng Liu Zhen Geng;Xueping Li;Luli Ji;Zhaoyang Li;Shengli Zhu;Zhenduo Cui;Jing Wang;Jingyuan Cui;Xianjin Yang;Changsheng Liu

作者机构：Key Laboratory for Ultrafine Materials of Ministry of EducationEast China University of Science and TechnologyShanghai200237China Tianjin Key Laboratory of Composite and Functional MaterialsSchool of Materials Science and EngineeringTianjin UniversityTianjin300350China Engineering Research Center for Biomedical Materials of the Ministry of EducationEast China University of Science and TechnologyShanghai200237China The State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai200237China Frontiers Science Center for Materiobiology and Dynamic ChemistryEast China University of Science and TechnologyShanghai200237China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2021年第79卷第20期

页      面：35-45页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0817[工学-化学工程与技术] 0806[工学-冶金工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0836[工学-生物工程] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：This work was financially supported by National Natural Science Foundation of China for Innovative Research Groups(Grant No.51621002) the China Postdoctoral Science Foundation(Grant No.2018M640350) 

主　　题：Bionic structure Bioactive apatite Osteoclast activity Osseointegration Bone-implant bonding strength 

摘      要：As the population ages,more and more people are suffering from osteoarthritis(OA),resulting in an increasing requirement for joint *** modification to improve the topology and composition of the implants has been proved to be an effective way to improve the primary stability and long-term success rate of joint *** this work,a bionic micro/nano-structure accompanied with a strontium-substituted hydroxyapatite(SrHA)coating was fabricated on titanium(Ti)surface via electrochemical corrosion,ultrasonic treatment,and hydrothermal deposition *** vitro study demonstrated that the bionic structure and the bioactive apatite could synergistically increase the expressions of integrin-related gene(ITGα5β1)and osteoblastic genes(Col-I and OCN),and thus promote osteoblast *** addition,owing to the anti-bone resorption property of Sr^(2+),the coating could effectively inhibit osteoclast differentiation and *** a word,the prepared samples not only promoted osteogenesis but also inhibited *** in vivo experiment via a rabbit model found that the bionic structured surface provided the pore for new bone ingrowth,which was beneficial to the mechanical interlocking between the implant and ***,the bionic structure and bioactive SrHA coating had a synergistic effect on promoting bone formation,osseointegration,and bone-implant bonding *** study therefore presented a new strategy to fabricate bio-functionalized Ti-based implants for potential application in orthopedics field.