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Fabrication and Characterization of Willemite Scaffolds Using Corn Stalk as a Novel bio template for Bone Tissue Engineering Applications

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Journal of bionic Engineering 2023年第1期20卷 16-29页

作者： Zahra Yahay Seyed Mehdi Mirhadi Fariborz Tavangarian Department of Cellular biotechnology Cell Science Research CenterRoyan Institute for BiotechnologyACECRIsfahan81593-58686Iran Department of Materials Engineering Shahreza BranchIslamic Azad UniversityShahrezaIsfahan86145-311Iran Mechanical Engineering Program School of ScienceEngineering and TechnologyPennsylvania State UniversityHarrisburgMiddletownPA17057USA

In this paper,we used Corn Stalk(CS)as a renewable and economical bio template to fabricate willemite scaffolds with the potential application in skull bone *** was used as a sacrificial template to synthesize the *** scaffolds with the chemical formula of Zn2SiO4 and pore size in the range of 3 to 10µm could be successfully synthesized by soaking CS in the willemite solution for 24 h and sintering at 950°C for 5 *** porosity of the samples was controlled by the soaking time(between 12 and 48 h)in the willemite solution from 5 to 35%,*** properties of these scaffolds showed a good approximation with cranial bone *** addition,cytotoxicity assays(MTT)were performed on Human Bone Marrow Stromal cells(HBMSc)and A172 human glioblastoma cell lines by direct and indirect culture methods to estimate their toxicity for bone and nerve cells,*** Phosphatase(ALP)activity and DAPI/Phalloidin cell staining were also performed to investigate the efficiency of the scaffolds for bone tissue engineering *** results showed that the scaffolds had good biocompatibility with both HBMSC and A172 cells,noticeable improvement on ALP activity,and great apatite formation ability in Simulated Body Fluid(SBF).All the evidence ascertained that willemite scaffolds made by corn stalks could be a useful candidate for bone tissue engineering applications.

关键词： Corn stalk bio template bioactive ceramics-Scaffolds Bone tissue engineering

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Yeast-TiO<sub>2</sub>biotemplate for Oxytetracycline Solar Photodecomposition

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Journal of Materials Science and Chemical Engineering 2020年第7期8卷 12-26页

作者： Nilce Ortiz Lucia Nascimento Fernanda Maichin Izabela Rodrigues Cerqueira Lima Azevedo Marília Guerino Vieira Institute for Nuclear and Energy Research—IPEN S&#227 o Paulo Brasil

The detection of the pharmaceutical compounds used in human and veterinary medicine is in several environmental matrices (surface waters, effluents, groundwater, soils, and sediments), and such presence promotes the resistance bacteria development, making them ineffective in some diseases treatment. The research project promotes the TiO2 synthesis using yeast culture as biotemplate, the step followed by the microstructure characterization with surface area enhancement;such properties are responsible for the improvement of solar photodecomposition processes of the veterinary antibiotic oxytetracycline. In such simple and standard process conditions the system reaches about 84% of removal percentage with a better agreement with the pseudo-first-order with the Pearson coefficient in the range from 0.82 to 0.94 and K1 = 0.035 M−1∙s−1. The degradation rate constant increased with the increasing initial Yeast-TiO2 dosage until the maximum mass of 0.1 g or with the decreasing of initial oxytetracycline concentration. The solar light used as a sustainable irradiation source is abundant and low cost in tropical countries, perfect to be applied in water treatment to decompose the pharmaceuticals pollutants, as the veterinarian antibiotics. The study demonstrates that solar photodecomposition is an efficient treatment technology for the removal of antibiotics from polluted water and provides insightful information on the potential practical application of this technology to treat contaminated water, possibly also in rural, distant areas.

关键词： Oxytetracycline Photodecomposition bio template Yeast Solar

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