Fabrication and Characterization of Willemite Scaffolds Using Corn Stalk as a Novel Bio Template for Bone Tissue Engineering Applications
作者机构：Department of Cellular BiotechnologyCell Science Research CenterRoyan Institute for BiotechnologyACECRIsfahan81593-58686Iran Department of Materials EngineeringShahreza BranchIslamic Azad UniversityShahrezaIsfahan86145-311Iran Mechanical Engineering ProgramSchool of ScienceEngineering and TechnologyPennsylvania State UniversityHarrisburgMiddletownPA17057USA
出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)
年 卷 期：2023年第20卷第1期
页 面：16-29页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：No funds grants or other support was received. The authors have no financial or proprietary interests in any material discussed in this article
主 题：Corn stalk Bio template Bioactive ceramics-Scaffolds Bone tissue engineering
摘 要：In this paper,we used Corn Stalk(CS)as a renewable and economical bio template to fabricate willemite scaffolds with the potential application in skull bone *** was used as a sacrificial template to synthesize the *** scaffolds with the chemical formula of Zn2SiO4 and pore size in the range of 3 to 10µm could be successfully synthesized by soaking CS in the willemite solution for 24 h and sintering at 950°C for 5 *** porosity of the samples was controlled by the soaking time(between 12 and 48 h)in the willemite solution from 5 to 35%,*** properties of these scaffolds showed a good approximation with cranial bone *** addition,cytotoxicity assays(MTT)were performed on Human Bone Marrow Stromal cells(HBMSc)and A172 human glioblastoma cell lines by direct and indirect culture methods to estimate their toxicity for bone and nerve cells,*** Phosphatase(ALP)activity and DAPI/Phalloidin cell staining were also performed to investigate the efficiency of the scaffolds for bone tissue engineering *** results showed that the scaffolds had good biocompatibility with both HBMSC and A172 cells,noticeable improvement on ALP activity,and great apatite formation ability in Simulated Body Fluid(SBF).All the evidence ascertained that willemite scaffolds made by corn stalks could be a useful candidate for bone tissue engineering applications.
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