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Evaluation of parasitemia by qPCR in patients with chronic Chagas disease treated with benznidazole

Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 565-572页

作者： Tycha Bianca Sabaini Pavan Eros Antônio de Almeida Rodrigo Gonçalves de Lima Jamiro da Silva Wanderley Luiz Cláudio Martins Sandra Cecília Botelho Costa Gláucia Elisete Barbosa Marcon Departamento de Clínica Médica Faculdade de Ciências MédicasUniversidade Estadual de Campinas(Unicamp)CampinasSão PauloBrasil Fundação Oswaldo Cruz Fiocruz Mato Grosso do SulCampo GrandeMSBrasil

Objective:To evaluate parasitemia by qPCR in patients undergoing etiological treatment and followed in a Brazilian reference ***:Parasite load was quantified by qPCR in 32 participants with chronic Chagas disease who were treated with *** analyses were performed before and after the treatment and parasite loads were compared prior and 12/18 months post the ***:Thirty-two participants were recruited and treated with benznidazole,and 20 were *** events(AE)were observed in 22 out of 29 participants that had safety data(76%),and dermatological alterations were the most frequently observed *** the 20 participants analyzed,13 and 7 completed 12 and 18 months follow-up after the treatment,respectively.12 Months after the final treatment,Trypanosoma cruzi was detectable in 3 patients by qPCR;18 months after the final treatment,Trypanosoma cruzi was detectable per qPCR in 4 of the 7 ***,between 12 and 18 months,7 participants of the 20 initial follow-up cases showed positive qPCR,indicating treatment ***:qPCR can be used as an alternative method for evaluating the effectiveness of the etiological treatment of CD,and can be applied to analyze early therapeutic *** study showed that benznidazole therapy had limited effectiveness in treating chronic CD patients,thus emphasizing the importance of conducting continued research for developing more effective therapies and diagnosis for CD.

关键词： Trypanosoma cruzi Chagas disease Antitrypanosomal therapy benznidazole qPCR Therapeutic failure

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2-硝基异吡唑衍生物benznidazole的作用方式

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国际医学寄生虫病杂志 1979年第2期 92-93页

作者：杨元清

作者试图通过下述指标的观察,阐明2一硝基异咄哇衍生物benznjdazole对克氏锥虫的作用方式。 1.对体外克氏锥虫的作用:将Y株克氏锥虫培养于含不同药物浓液的SGH肉汤培养基内,在37C孵育3天,置320倍相衬显微镜下

关键词：克氏锥虫衍生物 benznidazole 去氧核糖核酸硝基作用方式锥体虫

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Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries

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World Journal of Cardiology 2012年第7期4卷 234-239页

作者： Joana Cortez Rui Providência Evelise Ramos Cristina Valente Jorge Seixas Manuela Meruje António Leito-Marques António Vieira Infectious Diseases Department Coimbra's Hospital Centre and University Cardiology Department Coimbra's Hospital Centre and University Hygiene and Tropical Medicine Institute Universidade Nova de Lisboa Pathology Department Coimbra's Hospital Centre and University

Due to recent population emigration movements,an epidemic of Chagas disease is currently menacing most developed *** authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms,having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 *** diagnosis was based on serology and myocardial biopsy and the patient was treated with *** authors emphasize the need of a high level of suspicion in patients with suggestive epidemiology and the needof populational screening of specific high risk *** treatment options are also discussed.

关键词： Chagas disease Chagas cardiomyopathy Dysrhythmia Emigration Non-endemic countries benznidazole Nifurtimox

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