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Four new phenolic glycosides from baoyuan decoction

Acta Pharmaceutica Sinica B 2017年第2期7卷 173-178页

作者： Xiaoli Ma Xiaoyu Guo Mingbo Zhao Pengfei Tu Yong Jiang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Four new phenolic glycosides,including two flavonoid glycosides(1 and 2) and two lignan glycosides(3 and 4),were isolated from the traditional Chinese medicine formula,baoyuan *** structures were established by detailed analysis of the NMR and HR-ESI-MS spectroscopic data and their absolute configurations were determined by the experimental electronic circular dichroism data as well as chemical ***,the sources of the four new compounds were determined by the UPLC-Qtrap-MS method,which proved that 1 and 2 are originated from Glycyrrhiza uralensis,and 3 and4 are from Cinnamomum cassia.

关键词： baoyuan decoction Traditional Chinese med icine formula Flavonoid glycosides Lignan glycosides Electronic circular dichroism UPLC–Qtrap-MS

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baoyuan decoction alleviates myocardial infarction through the regulation of metabolic dysfunction and the mitochondria-dependent caspase-9/3 pathway

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Acupuncture and Herbal Medicine 2021年第1期1卷 49-58页

作者： Zhiyong Du Zeliu Shu Chun Li Xiaomin Song Xiaoli Ma Lixi Liao Jun Li Pengfei Tu Kewu Zeng Yong Jiang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina

Objective:baoyuan decoction(BYD)is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological *** present study aimed to investigate the effect and mechanism of BYD on alleviating myocardial infarction(MI).Methods:Nuclear magnetic resonance-based serum and urinary metabolomics were employed to explore the metabolic regulation effects of BYD in rats with MI induced by left anterior descending ***-glucose deprivation/recovery(OGD/R)model in H9c2 cells and multiple molecular biology approaches were used to clarify the underlying action mechanisms of ***:BYD treatment recovered the serum and urinary metabolite profiles of the MI rats toward normal metabolic status and significantly improved mitochondrial energy metabolism and apoptosis pathways perturbed by *** of the molecular mechanism of BYD indicated that it suppressed OGD/R-induced H9c2 cell apoptosis in a concentration-dependent manner by inhibiting the mitochondria-dependent caspase-9/3-poly ADP-ribose polymerase ***:Our results demonstrate that BYD protects against myocardial apoptosis via the mitochondrial metabolic and apoptosis *** also provide novel insights into the clinical application of BYD for the treatment of ischemic heart diseases.

关键词： baoyuan decoction Caspase-9/3 pathway Mechanisms Metabolomics Mitochondrial energy metabolism Myocardial infarction

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Exploring the molecular mechanism of baoyuan decoction in the treatment of lung cancer based on network pharmacology and molecular docking

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Integrative Medicine Discovery 2024年第19期8卷 1-11页

作者： Dan Wang Zhen-Hua Ge Bo-Ya Guan Ri-Cheng Jiang Hao Jin Center for Precision Cancer Medicine&Translational Research Tianjin Cancer Hospital Airport HospitalTianjin 300308China Department of Pharmacy Tianjin HospitalTianjin 300211China Department of Thoracic Oncology Tianjin Lung Cancer CenterTianjin Cancer Institute&HospitalTianjin Medical UniversityTianjin 300060China.

Background:baoyuan decoction is used clinically as an adjuvant treatment for lung ***,the underlying mechanism remains ***,this study aimed to explore the mechanism of action of baoyuan decoction in lung cancer treatment using network pharmacology and molecular docking ***:The Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform and SwissTargetPrediction databases were used to screen the active ingredients of baoyuan decoction and their relevant *** cancer-related targets were obtained from the GeneCards,Online Mendelian Inheritance in Man,and DrugBank ***-protein interaction network of the common targets was constructed using the STRING database and analyzed using Cytoscape software ***,Gene Ontology enrichment,Kyoto Encyclopedia of Genes and Genomes pathway analyses and visualization of common genes were performed using the R ***,molecular docking of the selected key ingredients and targets was performed,and the results were verified using AutoDock Vina ***:We identified 142 potential active ingredients,3624 potential lung cancer-related targets,and 341 common drug targets.A total of 72 core targets were identified,of which AKT1,TP53,interleukin-6,epithelial growth factor receptor,and signal transducer and activator of transcription 3 were key.A total of 4116 items were obtained via Gene Ontology enrichment *** Encyclopedia of Genes and Genomes pathway enrichment analyses revealed 189 related signaling pathways,including the PI3K-Akt,AGE-RAGE signaling pathways in diabetic complications,FOXO,and TH signaling pathways,which are involved in cell proliferation,autophagy,metastasis,invasion,radiation resistance,and chemotherapy resistance in the lung cancer *** molecular docking results suggested that the key ingredients had a strong affinity for key ***:This study demonstrates that baoyuan deco

关键词： baoyuan decoction lung cancer network pharmacology molecular docking mechanism research

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