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bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression

Cellular & Molecular Immunology 2022年第7期19卷 791-804页

作者： Yue Li Yi Yang Jin Wang Peihong Cai Mei Li Xixiang Tang Ying Tan Yuchan Wang Fan Zhang Xiaofeng Wen Qiaoxing Liang Yuanpeng Nie Tufeng Chen Xiang Peng Xuemin He Yanhua Zhu Guojun Shi Wai WCheung Lai Wei Yanming Chen Yan Lu Department of Endocrinology&Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology The Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center The Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Gastrointestinal Surgery The Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Rheumatology The Sixth Affliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuan 511518China Division of Pediatric Nephrology Rady Children's HospitalUniversity of CaliforniaSan DiegoCA 92093-0831USA

Type 2 diabetes(T2D)is highly associated with ***,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune ***-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during *** studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese *** further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell ***,accumulation of the bacterial strain bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese ***,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate ***,CD27−MAIT cell subsets and bacteroides ovatus could represent targets for novel interventional *** findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms.

关键词： type 2 diabetes obesity MAIT cells bacteroides ovatus bacterial translocation

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