Bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression
作者机构：Department of Endocrinology&MetabolismGuangdong Provincial Key Laboratory of DiabetologyThe Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical ImmunologyThe Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service CenterThe Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of OphthalmologyZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Gastrointestinal SurgeryThe Third Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of RheumatologyThe Sixth Affliated Hospital of Guangzhou Medical UniversityQingyuan People's HospitalQingyuan 511518China Division of Pediatric NephrologyRady Children's HospitalUniversity of CaliforniaSan DiegoCA 92093-0831USA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2022年第19卷第7期
页 面：791-804页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This study was funded by the National Key R&D Program of China(2017YFA0105803) the National Natural Science Foundation of China(32000621 and 81770826) the Key Area R&D Program of Guangdong Province(2019B020227003) the Science and Technology Plan Project of Guangzhou City(202102010338 and 202007040003) the 5010 Clinical Research Projects of Sun Yat-sen University(2015015) the Dengfeng Plan High-level Hospital Construction Opening Project of Foshan Fourth People’s Hospital(FSSYKF-2020009)
主 题：type 2 diabetes obesity MAIT cells Bacteroides ovatus bacterial translocation
摘 要：Type 2 diabetes(T2D)is highly associated with ***,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune ***-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during *** studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese *** further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell ***,accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese ***,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate ***,CD27−MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional *** findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms.
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