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bacteroides-derived isovaleric acid enhances mucosal immunity by facilitating intestinal IgA response in broilers

Journal of Animal Science and Biotechnology 2023年第3期14卷 1252-1273页

作者： Xinkai Wang Yifan Hu Xiaoyan Zhu Liyuan Cai Muhammad Zahid Farooq Xianghua Yan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Department of Animal Sciences University of Veterinary and Animal Sciences(Jhang Campus)Lahore 54000Pakistan

Background:The interaction between nutrition and immunity plays a vital role in nutrient digestion,absorption,and metabolism during poultry *** studies showed that the gut microbiota contributes to the development of intestinal mucosal ***,the mechanisms by which gut microbes regulate this process remain ***:We compared the intestinal mucosal immunity and gut microbiota of Arbor Acre broilers AA(lower mucosal immunity)and Chinese native Wuliang Mountain Black-bone chickens(WLMB)(higher mucosal immunity)using 16S rDNA sequencing,transcriptomic analysis,and immunoglobulin A(IgA)antibody repertoire *** then combined 16S rDNA sequencing with transcriptomics to identify the key microbes and found that they were positively correlated with IgA ***,we transplanted candidate microbes into 1-day-old broiler to explore their role in intestinal mucosal ***,we verified the function of candidate microbial metabolites in regulating the immune function of macrophages and the intestinal-epithelial cells(IECs)using in vitro ***:WLMB performs stronger mucosal immunity than AA,including higher IgA levels,more diverse IgA antibody repertoire,and higher bacterial *** was identified as the key microbes related to the intestinal IgA *** transplantation could increase IgA concentration in the duodenal contents by enhancing the expression of IgA,polymeric immunoglobin receptor(PIgR),B cell-activating factor of the TNF family(BAFF),and activation-induced cytidine deaminase(AID)in the ***,bacteroides-derived isovaleric acid promoted M2 macrophage polarization of macrophage via mTOR/PPAR-γ/STAT3 signaling pathways and regulated the immunologic function of IECs to produce cytokines,including interleukin(IL)-10,IL-4,BAFF,and transforming growth factor-beta(TGF-β),thus promoting IgA production in B cells by facilitating AID ***:Our study re

关键词： bacteroides Chicken IgA Intestinal health Isovaleric acid Macrophage

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bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health

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Food Science and Human Wellness 2022年第5期11卷 1101-1110页

作者： Jiaobo Cheng Jielun Hu Fang Geng Shaoping Nie State Key Laboratory of Food Science and Technology China-Canada Joint Lab of Food Science and Technology(Nanchang)Nanchang UniversityNanchang 330047China Key Laboratory of Coarse Cereal Processing(Ministry of Agriculture and Rural Affairs) School of Food and Biological EngineeringChengdu UniversityChengdu 610106China

Polysaccharide was a class of macromolecular substance with various bioactive *** symbiotic microorganisms could utilize the polysaccharides from various sources,thus have important impact on human *** represented one of the dominant colonizers in the human *** utilization of polysaccharide by bacteroides was important for supporting the function and stability of gut *** the degradation of polysaccharides by bacteroides,gut microbes could ferment the monosaccharides and oligosaccharides degraded from polysaccharides into some metabolites,such as short-chain fatty acids(SCFAs),amino acids,*** the metabolites,the SCFAs could have beneficial effects on gut *** review summarized the niches of bacteroides among gut microbiota,and also described the gene clusters and membrane proteins involved in the utilization processes of polysaccharide by gut *** could act as energy substrates for intestinal epithelial cells,inhibit histone deacetylases and activate G protein-coupled *** addition,the future perspectives in investigating new degradation pathways for polysaccharide,and using polysaccharides or their metabolites as therapeutic approaches for diseases mediated by the gut dysbiosis were also provided.

关键词： bacteroides Polysaccharides Degradation Short-chain fatty acids Gut health

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Lower abundance of bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

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Science China(Life Sciences) 2022年第10期65卷 2062-2075页

作者： Wen Ren Bing Yu Jie Yu Ping Zheng Zhiqing Huang Junqiu Luo Xiangbing Mao Jun He Hui Yan Jinlong Wu Daiwen Chen Yuheng Luo Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-resistant Nutrition of Sichuan Provinceand Animal Nutrition InstituteSichuan Agricultural UniversityChengdu61l130China DSM(China)Animal Nutrition Research Center Co. LtdBazhou 065799China

Growing evidences show a direct link between diarrhea and disorders of gut microbiota in ***,whether there are microbial markers associated with post-weaning diarrhea remains *** the current study,we compared the microbial community,functions and metabolites between healthy weaned piglets(group H,n=7)and piglets with post-weaning diarrhea(group D,n=7),in order to find out diarrhea associated microbial *** of 7 fecal samples was collected from H and D piglets(weaned at 21 d and sampled at 26 d).The metagenomic and untargeted metabolomic analysis revealed that the microbial composition,function and metabolic profile in D pigs was considerably reshaped,including the reduced abundance and number of bacteroides,which significantly correlated with the diarrhea status of *** carbohydrate metabolism,biosynthesis and metabolism,lipid metabolism,amino acid metabolism,and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H *** significantly changed the metabolic profiles of fecal microbiota,and most of the altered metabolites were negatively or positively correlated with the change in the abundance of *** conclusion,the lower abundance of bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.

关键词： post-weaning piglet diarrhea bacteroides metabolic dysfunction commensal microbiota

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Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase(FKP)in bacteroides fragilis

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Protein & Cell 2019年第5期10卷 365-369页

作者： Ying Liu Huifang Hu Jia Wang Qiang Zhou Peng Wu Nieng Yan Hong-Wei Wang Jia-Wei Wu Linfeng Sun Tsinghua-Peking Joint Center for Life Sciences School of Life SciencesTsinghua UniversityBeijing 100084China School of Life Sciences Tsinghua UniversityBeijing 100084China Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037USA Ministry of Education Key Laboratory of Protein Sciences Beijing Advaneed Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China CAS Center for Excellence in Molecular Cell Science Hefei National Laboratory for Physical Sciences at MicroscaleSchool of Life Scien cesUniversity of Science and Tech no logy of ChinaHefei 230027China

Dear Editor,L-Fucose(6-deoxy-L-galactose,fucose)is the basic compone nt of a variety of glyca n *** fucosylated oligosaccharides participate in a variety of cellular activities,like the cell-cell recognition,selectin-mediated leukocyteendothelial adhesion and the formation of Lewis blood group antigens(Ma et al.,2006).GDP-fucose is an important fucose donor in the process of fucosylated oligosaccharides *** pathways of GDP-fucose synthesis are present in the cytosol of mammalian cells,including the de novo pathway and the salvage pathway(Becker et al.,2003).In the salvage pathway,cells use fucose from the extracellular or lysosomal sources to synthesize GDP-fucose.

关键词： Cryo-EM structure pyrophosphorylase bacteroides fragilis

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Expression of enterotoxigenic bacteroides fragilis and polyketide synthase gene-expressing Escherichiacoli in colorectal adenoma patients

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China Medical Abstracts(Internal Medicine) 2016年第2期33卷 40-41页

作者：解玲玲 Dept Gastroenterol Peking Univ People's Hosp

Objective To investigate the distribution of various bacteria in adenoma tissue of colorectal adenoma(T/CRA),normal colonic mucosa tissue adjacent to the adenoma(N/CRA),and healthy colonic mucosa tissue(N/H)by compari... 详细信息

关键词： bacteroides adenoma colorectal mucosa colonic expressing colonoscopy Peking markedly tumorigenesis

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猪源Blautia hominis LYH1和bacteroides cellulosilyticus LYH2对小鼠结肠炎的保护作用研究

猪源Blautia hominis LYH1和Bacteroides cellulosilyticus LYH2...

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作者：刘洋四川农业大学

学位级别：硕士

炎症性肠病(Inflammatory bowel disease,IBD)是危害人类和规模化养殖动物的常见肠道疾病。饲料端抗生素禁用带来的动物肠道健康问题已被广泛关注,其中具有治疗肠道炎症作用的二代益生菌(Next-generation probiotics,NGP)的使用可能是... 详细信息

炎症性肠病(Inflammatory bowel disease,IBD)是危害人类和规模化养殖动物的常见肠道疾病。饲料端抗生素禁用带来的动物肠道健康问题已被广泛关注,其中具有治疗肠道炎症作用的二代益生菌(Next-generation probiotics,NGP)的使用可能是“替抗”手段之一。拟杆菌属(bacteroides,Ba)和布劳特属(Blautia,Bl)含有大量NGP候选菌株。本研究首先对前期从健康断奶仔猪肠道中分离的*** LYH1和*** LYH2菌株进行生物学鉴定;其次在体外以小鼠单核巨噬细胞(RAW264.7)胞内感染模型来评估两株细菌的免疫调节作用;最后以葡聚糖硫酸钠盐(Dextran sodium sulphate,DSS)诱导的结肠炎小鼠为模型,研究两株活菌及其代谢物对结肠炎的影响并初步揭示其预防结肠炎的作用机理,为动物养殖“替抗”策略的开发和肠炎的防治途径提供新思路。试验一猪源Blautia hominis LYH1和bacteroides cellulosilyticus LYH2的鉴定及其生物学特性研究首先参考伯杰氏系统细菌学手册和相关文献,结合16S r DNA序列分析、全基因组测序和非靶代谢组分结果,对前期分离的猪源*** LYH1(保藏于中国典型培养物保藏中心,保藏号为CCTCC NO:M 2021753)和*** LYH2(保藏号为CCTCC NO:M 2021754)进行生理生化、遗传学鉴定和生物学特性分析;随后对两株细菌进行体外抗生素耐药性和抑菌活性研究。主要结果如下:*** LYH1菌体呈卵圆状,革兰氏阳性,不产芽孢;*** LYH2菌体呈圆杆状,革兰氏阴性,不产芽孢。两株细菌都不溶血,不具有明胶酶活性、氧化酶活性和过氧化氢酶活性;*** LYH1对恩诺沙星、磺胺嘧啶、利福平等8种抗生素敏感,对万古霉素敏感性较弱,对阿莫西林、链霉素、克林霉素等6种抗生素不敏感;*** LYH2对多粘菌素、恩诺沙星、四环素敏感性较弱,对阿莫西林、利福平、氨苄西林等13种抗生素敏感;*** LYH1和*** LYH2对鼠伤寒沙门氏菌(Salmonella Typhimurium)、金黄色葡萄球菌ATCC 25923(Staphylococcus aureus)、大肠埃希氏菌ATCC 25922(Escherichia coli)具有不同的抑菌活性。其中*** LYH2对***的抑制作用最强;*** LYH1和*** LYH2基因组编码丰富的碳水化合物活性酶(Carbohydrate-Active enzymes,CAZymes),尤其是*** LYH2具有分解纤维素与半纤维素的能力;两株细菌的代谢物中都包含抗生素类似物。试验二猪源Blautia hominis LYH1和bacteroides cellulosilyticus LYH2对小鼠巨噬细胞的免疫调节作用采用小鼠单核巨噬细胞的RAW264.7细胞系构建***胞内感染模型,分别考察两株细菌对巨噬细胞免疫功能的影响。结果显示:*** LYH1和*** LYH2活菌和代谢物显著减少***的胞内复制量(Pbacteroides cellulosilyticus LYH2对DSS诱导的小鼠结肠炎的影响将60只体重相近、无特定病原体的6周龄雄性C57BL/6J小鼠随机分为6组:对照组、DSS组、DSS+活菌组

关键词： bacteroides Blautia 小鼠结肠炎

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脆弱拟杆菌(bacteroides fragilis)产肠毒素菌株和非产肠毒素菌株的抗原特性

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畜牧与饲料科学 1989年第2期18卷 37-39页

作者： Myers L.L. 胡贞延

从腹泻犊牛(62株)、羔羊(2株)和猪(5株)的粪便中获得脆弱拟杆菌产肠毒素株(44株)和非产肠毒素株(25株)。利用微量全细胞凝集试验和凝胶双扩散试验检测,菌株对13株脆弱拟杆菌产肠毒素菌株制备的非吸收兔抗血清有反应。脆弱拟杆菌有多种... 详细信息

从腹泻犊牛(62株)、羔羊(2株)和猪(5株)的粪便中获得脆弱拟杆菌产肠毒素株(44株)和非产肠毒素株(25株)。利用微量全细胞凝集试验和凝胶双扩散试验检测,菌株对13株脆弱拟杆菌产肠毒素菌株制备的非吸收兔抗血清有反应。脆弱拟杆菌有多种抗原。根据凝集反应,44株产肠毒素脆弱拟杆菌(ETBE)中有37株(84%)组成13个血清群、25株非产肠毒素脆弱拟杆菌(non—ETBF)中有14株(56%)组成13个血清群中的4个血清群。与凝胶扩散试验的结果比较,大部分菌株对13株抗血清有不同的凝集试验反应模式,从 non—ETBF 中不能区分ETBF。脆弱拟杆菌抗原的异源性促进了个别菌株的变异,这种能力对将来的流行病学和毒力研究是有益的。从腹泻犊牛、羔羊和猪的粪便中分离的ETBF,属于专性厌氧菌。利用肠结扎试验,证明脆弱拟杆菌在犊牛和羔羊中产生一种肠毒素,当给予新生羔羊口服时,证明 ETBF是腹泻病原。根据凝集和凝胶扩散分析,脆弱拟杆菌人株含有多种抗原,许多人株含有热稳定多糖荚膜抗原,可作为一种肠道外感染的毒力因子,有些脆弱拟杆菌人株也含有纤毛。本研究的目的,是根据抗原的不同,区分腹泻家畜的 ETBF 和 non—ETBF 的血清群,是否能从 non—ETBF 中区分 ETBF。

关键词：脆弱拟杆菌肠毒素血清群凝集试验凝胶扩散试验新生羔羊 bacteroides 反应模式凝集反应肠道外感染

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Anti-obesity and Gut Microbiota Modulation Effect of Astragalus Polysaccharides Combined with Berberine on High-Fat Diet-Fed Obese Mice

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Chinese Journal of Integrative Medicine 2023年第7期29卷 617-625页

作者： YUE Shi-jun WANG Wen-xiao ZHANG Lei LIU Juan FENG Wu-wen GAO Huan TANG Yu-ping YAN Dan Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing Shijitan HospitalCapital Medical UniversityBeijing100038China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi’an712046China Department of Pharmacy Beijing Friendship HospitalCaptical UniversityBeijing Institute of Clinical PharmacyBeijing100050China

Objective To investigate whether astragalus polysaccharides(APS)combined with berberine(BBR)can reduce high-fat diet(HFD)-induced obesity in *** Except for normal mice,32 HFD-induced obese mice were randomized into HFD,APS(1,000 mg/kg APS),BBR(200 mg/kg BBR),and APS plus BBR(1,000 mg/kg APS plus 200 mg/kg BBR)groups,*** 6-week treatment(once daily by gavage),the obesity phenotype and pharmacodynamic effects were evaluated by histopathological examination of epididymal fat,liver,and colon using hematoxylin-eosin staining and serum biochemical analyses by an automated chemistry *** feces were collected at the 12 th week,and taxonomic and functional profiles of gut microbiota were analyzed by 16S ribosomal ribonucleic acid(16S rRNA)*** Compared with HFD group,the average body weight of APS plus BBR group was decreased(Pbacteroides,which corresponded to the large increase of predicted bacterial genes involved in carbohydrate *** APS combined with BBR may synergistically reduce obesity and modulate the gut microbiota in HFD-fed mice.

关键词： Astragalus polysaccharides berberine obesity gut microbiota bacteroides

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Mucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum

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World Journal of Gastroenterology 2022年第8期28卷 811-824页

作者： Qiao-Li Jiang You Lu Meng-Jie Zhang Zhen-Yu Cui Zhong-Mei Pei Wen-Hua Li Lun-Gen Lu Jing-Jing Wang Ying-Ying Lu Department of Gastroenterology Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201803China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Shanghai Key Laboratory of Pancreatic Diseases Institute of Translational MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

BACKGROUND Nodular lymphoid hyperplasia(NLH)in the small intestine is a rare benign lesion characterized by multiple small nodules on the intestinal *** with terminal ileal NLH may experience long-term abdominal pain,diarrhea,and abdominal distension,among other *** with probiotics could mitigate these *** is linked to the immune system,and it may result from accumulation of plasma-cell precursors due to a maturational defect during the development of B *** intestinal microbiome plays an essential role in the immune ***,we speculate that the gut flora plays a key role in terminal ileal *** To explore the correlation between intestinal flora and terminal ileal *** We collected mucosal biopsy samples that were obtained via colonoscopy from 15 patients with terminal ileal NLH(the test group)and 15 normal subjects(the control group).We subsequently performed 16 S-r RNA gene amplicon sequencing of these samples,and the results were evaluated using alpha diversity,beta diversity and microbial composition *** Phylogenetic Investigation of Communities by Reconstruction of Unobserved States was used to predict the metabolic pathways and orthologous groups according to the Kyoto Encyclopedia of Genes and Genomes *** Compared with the control group,the terminal ileal NLH group showed an increased alpha diversity(Pbacteroides was the dominant gut microbiota in both groups,but its abundance was significantly lower in the test group than it was in the control ***,the relative abundances of Haemophilus,Strep

关键词： Hyperplasia bacteroides Small intestine Microbiome Helicobacter pylori Colonoscopy

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Capsular polysaccarides of probiotics and their immunomodulatory roles

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Food Science and Human Wellness 2022年第5期11卷 1111-1120页

作者： Jing Li Saisai Feng Leilei Yu Jianxin Zhao Fengwei Tian Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Studies have determined the immunomodulatory activities of cell-surface polysaccharides of lactic acid bacteria(LAB)and bacteroides;however,the mechanisms,synthesis,regulation,structure,and functional links have not been systematically *** first introduce the structure of the capsular poly saccharides(CPS s)of commonly studied probiotics and ***-Wzy dependent and ATP-binding cassette(ABC)transporter-dependent pathways are the two main biosynthesis and secretion of CPS *** genes known to be associated with these two pathways are mainly those associated with priming glycosyltransferase(pGT);a variable number of genes encoding for different glycosyl transferases(GTs);Wzx/Wzy-encoding enzymes related to flippases and polymerases;and ABC-transporter *** addition,the effects of CPSs on host immunity as well as their related underlying mechanisms are *** polysaccharides on probiotics can serve as a mask to aid in their escape from attacks from the host’s immune *** turn,they also exhibit immunomodulatory activities,such as strengthening the functions of macrophages,promoting the maturation of antigen-presenting cells,and inducing regulatory T *** of these effects of cell-surface polysaccharides exhibit their significant protective properties in immunocompromised diseases,such as colitis,arthritis,and ***,we focused on their structure and functional links.

关键词： Capsular polysaccharides Probiotics bacteroides Immunomodulation

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